4-Methyl-2-phenylpent-2-enoic acid | 773869-07-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-Methyl-2-phenylpent-2-enoic acid
• 英文别名: 4-methyl-2-phenylpent-2-enoic acid
• CAS: 773869-07-1
• 化学式: C₁₂H₁₄O₂
• 分子量: 190.242
• InChiKey: WXSDEEZBBBWHNL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-Methyl-2-phenylpent-2-enoic acid 在 草酰氯 作用下， 生成
  参考文献：
  名称：

  Synthesis of β-, γ-, and δ-Lactams via Pd(II)-Catalyzed C−H Activation Reactions

  摘要：

  Pd(II)-catalyzed intramolecular amination of Sp(2) and Sp(3) C-H bonds are developed using a combination of CuCl2 and AgOAc as the oxidant. The reaction protocol tolerates the presence of a double bond in the substrates. This catalytic reaction provides practical access to a wide range of beta-, gamma-, and delta-lactams.

  DOI：

  10.1021/ja807129e
• 作为产物：
  描述：

  苯乙酸 、 异丁醛 在 三乙胺 作用下， 以 乙酸酐 为溶剂， 反应 12.0h， 生成 4-Methyl-2-phenylpent-2-enoic acid
  参考文献：
  名称：

  Synthesis of β-, γ-, and δ-Lactams via Pd(II)-Catalyzed C−H Activation Reactions

  摘要：

  Pd(II)-catalyzed intramolecular amination of Sp(2) and Sp(3) C-H bonds are developed using a combination of CuCl2 and AgOAc as the oxidant. The reaction protocol tolerates the presence of a double bond in the substrates. This catalytic reaction provides practical access to a wide range of beta-, gamma-, and delta-lactams.

  DOI：

  10.1021/ja807129e

文献信息

• MONOMERS CAPABLE OF DIMERIZING IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME
  申请人：CORNELL UNIVERSITY

  公开号：US20200354319A1

  公开（公告）日：2020-11-12

  Described herein are monomers capable of forming a biologically useful multimer when in contact with one, two, three or more other monomers in an aqueous media. In one aspect, such monomers may be capable of binding to another monomer in an aqueous media (e.g. in vivo) to form a multimer, (e.g. a dimer). Contemplated monomers may include a ligand moiety, a linker element, and a connector element that joins the ligand moiety and the linker element. In an aqueous media, such contemplated monomers may join together via each linker element and may thus be capable of modulating one or more biomolecules substantially simultaneously, e.g., modulate two or more binding domains on a protein or on different proteins.
• Synthesis of β-, γ-, and δ-Lactams via Pd(II)-Catalyzed C−H Activation Reactions
  作者：Masayuki Wasa、Jin-Quan Yu

  DOI：10.1021/ja807129e

  日期：2008.10.29

  Pd(II)-catalyzed intramolecular amination of Sp(2) and Sp(3) C-H bonds are developed using a combination of CuCl2 and AgOAc as the oxidant. The reaction protocol tolerates the presence of a double bond in the substrates. This catalytic reaction provides practical access to a wide range of beta-, gamma-, and delta-lactams.