N-Acetyl-N-(β-cyanethyl)-hydrazin | 5678-80-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-Acetyl-N-(β-cyanethyl)-hydrazin
• 英文别名: N-(2-cyanoethyl)acetohydrazide
• CAS: 5678-80-8
• 化学式: C₅H₉N₃O
• 分子量: 127.146
• InChiKey: GAIRJQARZJXQEN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.3
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  70.1
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-(2-acetyl-4-chlorophenyl)trifluoromethanesulfonamide 、 N-Acetyl-N-(β-cyanethyl)-hydrazin 以 乙醇 为溶剂， 反应 16.0h， 生成 N-(2-(1-(2-acetyl-2-(2-cyanoethyl)hydrazineylidene)ethyl)-4-chlorophenyl)-1,1,1-trifluoromethanesulfonamide
  参考文献：
  名称：

  Discovery of ectoparasiticidal hydrazonotrifluoromethanesulfonanilides

  摘要：

  A series of hydrazonotrifluorosulfonanilide derivatives were synthesized and evaluated for in vitro activity against the ectoparasites Ctenocephalides felis and Rhipicephalus sanguineus. Some compounds with excellent activity against tick were identified. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.11.054
• 作为产物：
  描述：

  乙酰氯 、 2-氰基乙基肼 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 生成 N-Acetyl-N-(β-cyanethyl)-hydrazin
  参考文献：
  名称：

  Discovery of ectoparasiticidal hydrazonotrifluoromethanesulfonanilides

  摘要：

  A series of hydrazonotrifluorosulfonanilide derivatives were synthesized and evaluated for in vitro activity against the ectoparasites Ctenocephalides felis and Rhipicephalus sanguineus. Some compounds with excellent activity against tick were identified. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.11.054

文献信息

• ELNAGDI M. H.; FLEITA D. H.; EL-MOGHAYAR. M. R. H., TETRAHEDRON <TETR-AB>, 1975, 31, NO 1, 63-67
  作者：ELNAGDI M. H.、 FLEITA D. H.、 EL-MOGHAYAR. M. R. H.

  DOI：——

  日期：——
• Discovery of ectoparasiticidal hydrazonotrifluoromethanesulfonanilides
  作者：Abdelselam Ali、Petr Fisara、Jamie A. Freemont、Stella Kyi、Adam G. Meyer、Andrew G. Riches、Roger M. Sargent、David G. Sawutz、Kathleen A. Turner、Kevin N. Winzenberg、Qi Yang

  DOI：10.1016/j.bmcl.2009.11.054

  日期：2010.1

  A series of hydrazonotrifluorosulfonanilide derivatives were synthesized and evaluated for in vitro activity against the ectoparasites Ctenocephalides felis and Rhipicephalus sanguineus. Some compounds with excellent activity against tick were identified. (C) 2009 Elsevier Ltd. All rights reserved.