7-(8'-hydroxyoctyloxy)chromen-2-one | 808761-79-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 7-(8'-hydroxyoctyloxy)chromen-2-one
• 英文别名: 7-(8-Hydroxyoctoxy)chromen-2-one
• CAS: 808761-79-7
• 化学式: C₁₇H₂₂O₄
• 分子量: 290.359
• InChiKey: QJHBUWOGZZUGIN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  21
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  7-(8'-hydroxyoctyloxy)chromen-2-one 在 Celite 、 pyridinium chlorochromate 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 生成 7-(8'-oxooctyloxy)chromen-2-one
  参考文献：
  名称：

  Umbelliferone aminoalkyl derivatives, a new class of squalene-hopene cyclase inhibitors

  摘要：

  The synthesis is described of several aminoalkyl derivatives of coumarin, obtained in good yields under microwave or high-intensity ultrasound irradiation. These compounds proved uniformly active as inhibitors of squalene-hopene cyclase (SHC) from Alicyclobacilhis acidocaldarius. Their design stemmed from our recent finding that the umbelliferone nucleus acquires inhibitory properties towards SHC when functionalized with a suitable chain such as the omega-epoxyfarnesyl group. Under our experimental conditions the most active ones, such as 7-(4'-allyimethylamino-but-2-ynyloxy)chromen-2-one (IC50 0.75 mM), approached the potency of anticholesteremic drug Ro 48-8071 (IC50 0.35 mM), an effective inhibitor of both squalene- and oxidosqualene-cyclases (OSC). Tests are in progress to determine their efficacy on different eukaryotic OSCs. (C) 2004 Elsevier SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2004.06.010
• 作为产物：
  描述：

  7-羟基香豆素 、 8-溴-1-辛醇 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 反应 7.0h， 生成 7-(8'-hydroxyoctyloxy)chromen-2-one
  参考文献：
  名称：

  Umbelliferone aminoalkyl derivatives, a new class of squalene-hopene cyclase inhibitors

  摘要：

  The synthesis is described of several aminoalkyl derivatives of coumarin, obtained in good yields under microwave or high-intensity ultrasound irradiation. These compounds proved uniformly active as inhibitors of squalene-hopene cyclase (SHC) from Alicyclobacilhis acidocaldarius. Their design stemmed from our recent finding that the umbelliferone nucleus acquires inhibitory properties towards SHC when functionalized with a suitable chain such as the omega-epoxyfarnesyl group. Under our experimental conditions the most active ones, such as 7-(4'-allyimethylamino-but-2-ynyloxy)chromen-2-one (IC50 0.75 mM), approached the potency of anticholesteremic drug Ro 48-8071 (IC50 0.35 mM), an effective inhibitor of both squalene- and oxidosqualene-cyclases (OSC). Tests are in progress to determine their efficacy on different eukaryotic OSCs. (C) 2004 Elsevier SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2004.06.010

文献信息

• COMPOSITION FORMING HEAT-CURED FILM HAVING PHOTO-ALIGNMENT PROPERTIES
  申请人：Nissan Chemical Industries, Ltd.

  公开号：EP2557102A1

  公开（公告）日：2013-02-13

  There is provided a material that exhibits high solvent resistance after the formation of a cured film, excellent photo-alignment capability relative to a polymerizable liquid crystal, satisfactory heat resistance, and high transparency and moreover, that can be dissolved in a glycol-based solvent, a ketone-based solvent, or a lactic acid ester-based solvent that is applicable to the production of an overcoating of a color filter, during the formation of the cured film. A composition for forming thermoset film having photo-alignment properties, comprising: a component (A) that is a compound having a photo-aligning group and a hydroxy group; and a component (B) that is a silicon isocyanate compound. A liquid crystal alignment layer formed from the thermoset film forming composition, and an optical device with a retardation layer obtained by use of the thermoset film forming composition.

  本发明提供了一种材料，该材料在形成固化膜后具有较高的耐溶剂性，与可聚合液晶相比具有优异的光对准能力，耐热性令人满意，透明度高，而且在形成固化膜期间可溶解在乙二醇基溶剂、酮基溶剂或乳酸酯基溶剂中，适用于生产彩色滤光片的外涂层。一种用于形成具有光对准特性的热固性薄膜的组合物，包括：组分（A），即具有光对准基团和羟基的化合物；以及组分（B），即硅异氰酸酯化合物。由该热固性成膜组合物形成的液晶配向层，以及通过使用该热固性成膜组合物而获得的具有延缓层的光学器件。
• CURED FILM FORMATION COMPOSITION, ORIENTATION MATERIAL, AND PHASE DIFFERENCE MATERIAL
  申请人：Nissan Chemical Industries, Ltd.

  公开号：EP2767562A1

  公开（公告）日：2014-08-20

  There is provided a cured-film formation composition that forms a cured film having excellent photoreaction efficiency and solvent resistance, and high adhesion, an orientation material for photo-alignment, and a retardation material formed with the orientation material. The cured-film formation composition comprises a component (A) that is a compound having a photo-aligning group and one substituent selected from a hydroxy group, a carboxy group, and an amino group; a component (B) that is a hydrophilic polymer having one or more substituents selected from a hydroxy group, a carboxy group, and an amino group; and a component (C) that is a cross-linking agent that reacts with the component (A) and the component (B) and reacts at a temperature lower than a sublimation temperature of the component (A), wherein when the component (B) is an acrylic polymer, the cured-film formation composition further comprises a component (E) that is an adhesion enhancing component. The cross-linking agent of the component (C) may be more hydrophilic than the component (A). The orientation material is formed by forming a cured film with the cured-film formation composition and utilizing photo-alignment technique. The retardation material is obtained by applying a polymerizable liquid crystal on the orientation material and curing it.

  本发明提供了一种固化成膜组合物，该组合物可形成具有优异光反应效率和耐溶剂性以及高附着力的固化膜，还提供了一种用于光配位的配向材料，以及一种与配向材料形成的延缓材料。固化成膜组合物包括：组分（A），即具有光配位基团和一个选自羟基、羧基和氨基的取代基的化合物；组分（B），即具有一个或多个选自羟基、羧基和氨基的取代基的亲水性聚合物；和一种成分（C），它是一种交联剂，可与成分（A）和成分（B）反应，反应温度低于成分（A）的升华温度，其中当成分（B）是丙烯酸聚合物时，固化成膜组合物还包括一种成分（E），它是一种附着力增强成分。组分（C）的交联剂可能比组分（A）更亲水。定向材料是通过使用固化成膜组合物形成固化膜并利用光对准技术形成的。将可聚合液晶涂抹在取向材料上并使其固化，即可获得缓凝材料。
• COMPOSITION FOR FORMING THERMOSET FILM HAVING PHOTO-ALIGNMENT PROPERTIES
  申请人：Nissan Chemical Industries, Ltd.

  公开号：EP2557102B1

  公开（公告）日：2017-06-07
• CURED FILM FORMATION COMPOSITION, ORIENTATION MATERIAL, AND RETARDATION MATERIAL
  申请人：NISSAN CHEMICAL INDUSTRIES, LTD.

  公开号：US20140239240A1

  公开（公告）日：2014-08-28

  There is provided a cured-film formation composition that forms a cured film having excellent photoreaction efficiency and solvent resistance, and high adhesion, an orientation material for photo-alignment, and a retardation material formed with the orientation material.
• CURED-FILM FORMATION COMPOSITION, ORIENTATION MATERIAL, AND RETARDATION MATERIAL
  申请人：NISSAN CHEMICAL INDUSTRIES, LTD.

  公开号：US20150191572A1

  公开（公告）日：2015-07-09

  A cured-film formation composition for forming a cured film having photoreaction efficiency and solvent resistance, and high adhesiveness alignment uniformity, and an orientation material for photo-alignment, and a retardation material formed by use of the orientation material. A cured-film formation composition includes (A) a compound having a photo-aligning group and one substituent selected from a hydroxy group, a carboxy group, and an amino group; (B) a hydrophilic polymer having one or more substituents selected from a hydroxy group, a carboxy group, and an amino group; and (C) a polymer obtained by polymerizing a monomer including an N-hydroxymethyl compound or an N-alkoxymethyl (meth)acrylamide compound, and optionally further a cross-linking catalyst as a component (D). By use of the composition, a cured-film is formed and an orientation material is formed by utilizing photo-alignment technique. A retardation material is obtained by applying a polymerizable liquid crystal on the orientation material and curing it.