2-(4-氨基苯基)萘-1-甲醛 | 93980-65-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-(4-氨基苯基)萘-1-甲醛
• 英文名称: 4-aminophenyl-1-naphthylketone
• 英文别名: (4-Aminophenyl)naphthylketone；(4-aminophenyl)-naphthalen-1-ylmethanone
• CAS: 93980-65-5
• 化学式: C₁₇H₁₃NO
• mdl: MFCD19433018
• 分子量: 247.296
• InChiKey: UGSYXNDKIWVIRW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(4-氨基苯基)萘-1-甲醛 在 sodium tetrahydroborate 作用下， 以 四氢呋喃 、 水 、 溶剂黄146 为溶剂， 反应 1.5h， 生成 Naphthalen-1-yl-(4-pyrrol-1-ylphenyl)methanol
  参考文献：
  名称：

  Research on antibacterial and antifungal agents. 16. Synthesis and antifungal activities of 1-[α-(1-naphthyl)benzyl]imidazole derivatives and related 2-naphthyl isomers

  摘要：

  Some 1-arylmethylimidazoles bearing a naphthyl group at the a position of benzyl moiety have been synthesized and tested as antifungal agents against Candida albicans and Candida spp. Such derivatives resemble bifonazole and naftifine, two important antimycotic agents of clinical use. Various compounds were found highly active when tested against Candida strains in comparison with bifonazole, miconazole, clotrimazole and ketoconazole.

  DOI：

  10.1016/0223-5234(92)90089-j
• 作为产物：
  描述：

  1-萘基(4-硝基苯基)甲酮 在 盐酸 、 tin(ll) chloride 作用下， 以 丙酮 为溶剂， 反应 0.33h， 以97%的产率得到2-(4-氨基苯基)萘-1-甲醛
  参考文献：
  名称：

  Research on antibacterial and antifungal agents. 16. Synthesis and antifungal activities of 1-[α-(1-naphthyl)benzyl]imidazole derivatives and related 2-naphthyl isomers

  摘要：

  Some 1-arylmethylimidazoles bearing a naphthyl group at the a position of benzyl moiety have been synthesized and tested as antifungal agents against Candida albicans and Candida spp. Such derivatives resemble bifonazole and naftifine, two important antimycotic agents of clinical use. Various compounds were found highly active when tested against Candida strains in comparison with bifonazole, miconazole, clotrimazole and ketoconazole.

  DOI：

  10.1016/0223-5234(92)90089-j

文献信息

• Phosphorescent materials
  申请人：THE POST OFFICE

  公开号：EP0325825B1

  公开（公告）日：1992-09-16
• LUMINESCING INKS AND USE OF SUCH INKS IN CODING AND OTHER MARKING OPERATIONS
  申请人：THE POST OFFICE

  公开号：EP0914392A1

  公开（公告）日：1999-05-12
• US5100580A
  申请人：——

  公开号：US5100580A

  公开（公告）日：1992-03-31
• [EN] LUMINESCING INKS AND USE OF SUCH INKS IN CODING AND OTHER MARKING OPERATIONS<br/>[FR] ENCRES LUMINESCENTES ET UTILISATIONS DE CES ENCRES POUR LE CODAGE ET AUTRES OPERATIONS DE MARQUAGE
  申请人：THE POST OFFICE

  公开号：WO1998003596A1

  公开（公告）日：1998-01-29

  (EN) Coding of items of mail is achieved to good effect irrespective of the moisture content of the mail and/or ambient relative humidity by applying to at least one part of the surface a composition comprising both phosphorescence activation means and fluorescence activation means such that exposure of the surface to ultraviolet light will lead to an emission of detectable phosphorescence to an extent which will depend upon the amount of moisture at the surface. Fluorescence will be activated irrespective of moisture content. Preferably red phosphorescence and red fluorescence are manifested.(FR) Selon la présente invention, on effectue le codage d'objets postaux de façon à parvenir au meilleur effet quel que soit le degré hygrométrique desdits objets postaux et/ou l'humidité relative ambiante. Le procédé utilisé consiste à appliquer sur au moins une partie de la surface de l'objet une composition contenant à la fois un agent d'activation de la phosphorescence et un agent d'activation de la fluorescence de telle sorte que l'exposition de ladite surface à un rayonnement ultraviolet provoque l'émission d'une phosphorescence décelable jusqu'à un degré qui est fonction du degré hygrométrique au niveau de ladite surface. La fluorescence est activée quel que soit le degré hygrométrique. De préférence, les agents activateurs utilisés engendrent une phosphorescence rouge et une fluorescence rouge.
• Research on antibacterial and antifungal agents. 16. Synthesis and antifungal activities of 1-[α-(1-naphthyl)benzyl]imidazole derivatives and related 2-naphthyl isomers
  作者：M Artico、G Stefancich、R Silvestri、S Massa、G Apuzzo、M Artico、G Simonetti

  DOI：10.1016/0223-5234(92)90089-j

  日期：1992.10

  Some 1-arylmethylimidazoles bearing a naphthyl group at the a position of benzyl moiety have been synthesized and tested as antifungal agents against Candida albicans and Candida spp. Such derivatives resemble bifonazole and naftifine, two important antimycotic agents of clinical use. Various compounds were found highly active when tested against Candida strains in comparison with bifonazole, miconazole, clotrimazole and ketoconazole.