2,6-diamino-6-phosphonohexanoic acid | 137407-84-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2,6-diamino-6-phosphonohexanoic acid
• 英文别名: 2,6-Diamino-6-phosphono-hexanoic acid
• CAS: 137407-84-2
• 化学式: C₆H₁₅N₂O₅P
• 分子量: 226.169
• InChiKey: VSLQSQRRJBOXLA-UHFFFAOYSA-N

物化性质

• 沸点：
  529.8±60.0 °C(Predicted)
• 密度：
  1.513±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -7.2
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  147
• 氢给体数：
  5
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  N-phthaloyl-α-aminoadipic acid 在 盐酸 、 dimethyl sulfide borane 、 sodium sulfate 、 三乙胺 、 pyridinium chlorochromate 、 methyloxirane 作用下， 以 二氯甲烷 、 氯仿 为溶剂， 反应 4.0h， 生成 2,6-diamino-6-phosphonohexanoic acid
  参考文献：
  名称：

  Synthesis and antibacterial evaluation of phosphonic acid analogues of diaminopimelic acid

  摘要：

  Diaminopimelic acid is an essential amino acid in the peptidoglycan of Gram-negative bacteria, mycobacteria and some Gram-positive bacteria. It can be used as a target for the development of antibacterial agents. In this article the synthesis of a series of phosphonic acid analogues of this diamino-dicarboxylic acid is described: mono- and diphosphonic acid derivatives as well as their homologues, N-alkyl analogues and some peptidyl derivatives. A phenylphosphinic derivative was also prepared. All the prepared compounds were tested for their antibacterial activity against a series of Gram-positive, Gram-negative and mycobacteria. They were also tested as possible inhibitors of the UDP-MurNAc-L-Ala-gamma-D-Glu: meso-DAP synthetase. No significant biological activity was found.

  DOI：

  10.1016/0223-5234(91)90146-e

文献信息

• Phosphoamidase assay
  申请人：Kellner Roland

  公开号：US20050124023A1

  公开（公告）日：2005-06-09

  The present invention relates to the use of compounds and to methods for the qualitative and/or quantitative determination of the activity of phosphoamidases or protein phosphoamidases specific for hydrolyzing phosphoamide (P—N) bonds. N-phosphorylated basic amino acids like phospholysine, phosphoarginine and phosphohistidine.

  本发明涉及化合物的使用以及定性和/或定量测定专门用于水解磷酸酰胺（P-N）键的磷酸酰胺酶或蛋白质磷酸酰胺酶活性的方法。N-磷酸化碱性氨基酸，如磷酰赖氨酸、磷精氨酸和磷组氨酸。
• PHOSPHOAMIDASE ASSAY
  申请人：Merck Patent GmbH

  公开号：EP1468108B1

  公开（公告）日：2005-12-14
• US7348160B2
  申请人：——

  公开号：US7348160B2

  公开（公告）日：2008-03-25
• [EN] PHOSPHOAMIDASE ASSAY<br/>[FR] DOSAGE DE PHOSPHOAMIDASES
  申请人：MERCK PATENT GMBH

  公开号：WO2004044233A1

  公开（公告）日：2004-05-27

  The present invention relates to the use of compounds and to methods for the qualitative and/or quantitative determination of the activity of phosphoamidases or protein phosphoamidases specific for hydrolyzing phosphoamide (P-N) bonds of N-phosphorylated basic amino acids like phospholysine, phosphoarginine and phosphohistidine.