2,2-Dimethyl-tetrahydro-[1,3]oxazin | 73155-29-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 2,2-Dimethyl-tetrahydro-[1,3]oxazin
• 英文别名: 2,2-dimethyl-[1,3]oxazinane；2,2-Dimethyl-1,3-oxazinane
• CAS: 73155-29-0
• 化学式: C₆H₁₃NO
• 分子量: 115.175
• InChiKey: SZIXSHHJKNYJGQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,2-Dimethyl-tetrahydro-[1,3]oxazin 生成 3-Isopropylideneamino-propan-1-ol
  参考文献：
  名称：

  PIHLAJA K., FINN. CHEM. LETT., 14,(1987) N 3-4, 113

  摘要：

  DOI：
• 作为产物：
  描述：

  3-Isopropylideneamino-propan-1-ol 生成 2,2-Dimethyl-tetrahydro-[1,3]oxazin
  参考文献：
  名称：

  PIHLAJA K., FINN. CHEM. LETT., 14,(1987) N 3-4, 113

  摘要：

  DOI：

文献信息

• THE SYNTHESIS OF SOME INDOLYLALKYLAMINOALCOHOLS
  作者：Gerassimos Frangatos、Geza Kohan、Francis L. Chubb

  DOI：10.1139/v60-201

  日期：1960.9.1

  A series of 3-indolylalkylaminoalcohols have been obtained from the lithium aluminum hydride reduction of the amides prepared by the reaction of 3-indoleglyoxylyl chloride and 2-methyl-3-indoleglyoxylyl chloride with primary aminoalcohols. When acetone was used as solvent in the reaction of 3-indoleglyoxylyis chloride and either 2-aminoethanol or 3-aminopropanol, the solvent participated in the reaction

  由3-吲哚乙二甲酰氯和2-甲基-3-吲哚乙二甲酰氯与伯氨基醇反应制备的酰胺的氢化铝锂还原得到一系列3-吲哚烷基氨基醇。当丙酮用作 3-吲哚乙醛酰氯与 2-氨基乙醇或 3-氨基丙醇反应的溶剂时，溶剂参与反应生成 2,2-二甲基-3-（3-吲哚乙醛氧基）恶唑烷和分别为 2,2-二甲基-3-(3-indoleglyoxyl)tetrahydro-1,3-oxazine。当后两种化合物被氢化铝锂还原时，两个羰基都被完全还原，恶唑烷和四氢-1,3-恶嗪环发生还原裂解，形成相应的开链醇。
• Spirocyclic nitriles as protease inhibitors
  申请人：Schudok Manfred

  公开号：US20090275523A1

  公开（公告）日：2009-11-05

  The invention relates to substituted carbo- and heterocyclic spiro compounds of the formula Ia which inhibit thiol proteases, to processes for their preparation and to the use thereof as medicaments.

  这项发明涉及公式Ia的取代碳氢和杂环螺环化合物，其抑制硫醇蛋白酶，以及它们的制备方法和用作药物的用途。
• Novel 2,5-Substituted Pyrimidines
  申请人：Grunenthal GmbH

  公开号：US20160024053A1

  公开（公告）日：2016-01-28

  The invention relates to novel substituted condensed pyrimidine compounds of general formula (I) in which the chemical groupings, substituents and indices are as defined in the description, and to their use as medicaments, in particular as medicaments for the treatment of conditions and diseases that can be treated by inhibition of the PDE4 enzyme.

  该发明涉及一种新型的取代紧缩嘧啶化合物，其一般式为(I)，其中化学基团、取代基和指数如描述中所定义，并且其用作药物，特别是用作治疗通过抑制PDE4酶可治疗的状况和疾病的药物。
• NAPHTHYRIDINE DERIVATIVE
  申请人：Mitsuoka Yasunori

  公开号：US20130217705A1

  公开（公告）日：2013-08-22

  The present invention provides, for example, the following compound: wherein ring Z is pyridine or a carbocycle, each of which is substituted or unsubstituted, ring A is a carbocycle or a heterocycle, each of which is substituted or unsubstituted, R 1 is substituted or unsubstituted alkyl or the like, R 2a , R 2b , R 4a and R 4b are each independently hydrogen or substituted or unsubstituted alkyl or the like, its pharmaceutically acceptable salt or a solvate thereof having an effect of inhibiting amyloid β production, especially a BACE1 inhibitory activity, and useful as a medicament for treating diseases induced by production, secretion or deposition of amyloid β proteins.

  本发明提供了以下化合物：其中环Z是吡啶或碳环，每个都是取代或未取代的，环A是碳环或杂环，每个都是取代或未取代的，R1是取代或未取代的烷基或类似物，R2a、R2b、R4a和R4b分别独立地是氢或取代或未取代的烷基或类似物，其药学上可接受的盐或其溶剂化合物具有抑制淀粉样蛋白β产生的作用，特别是BACE1抑制活性，并且作为治疗由淀粉样蛋白β蛋白的产生、分泌或沉积引起的疾病的药物而有用。
• Delta-hydroxy-beta-lysine derivatives and their production
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP0271829A2

  公开（公告）日：1988-06-22

  compound of the formula wherein R' and R4 are independently amino or an organic residue bonded through nitrogen, R2 is hydrogen or alkyl which may be substituted, R3 is hydrogen or a protecting group and R5 is hydroxyl which may be substituted or amino which may be substituted or salts thereof; with the proviso that when R1 is amino, sorbylamino or hexanoylamino, R2 is hydrogen or methyl, R4 is amino which may be protected adn R5 is hydroxyl or 2-amidinoethylamino, R3 is a protecting group, and that when R1 is amino, leucylamino, acetylamino or benzyloxycarbonylamino, R3 is hydrogen, methyl or 2-tettrahydropyranyl, R4 is amino, acetylamino or benzyloxycarbonylamino and R5 is hydroxyl which may be substituted or amino which may be substituted, R2 is alkyl which may be substituted, has antibacterial activities against drug-resistant bacteria and therefore can be useful as a chemotherapeutic drug for bacterial infections in mammals.

  式中的化合物 其中 R' 和 R4 独立地为氨基或通过氮键合的有机残基，R2 为氢或可被取代的烷基，R3 为氢或保护基团，R5 为可被取代的羟基或可被取代的氨基或其盐；但当 R1 为氨基、山梨氨基或己酰氨基时，R2 为氢或甲基，R4 为可被保护的氨基，R5 为羟基或 2-脒乙基氨基，R3 为保护基；当 R1 为氨基、月桂氨基、乙酰氨基或苄氧羰基氨基时，R3 为氢、甲基或 2-四氢吡喃基、R4 是氨基、乙酰氨基或苄氧羰基氨基，R5 是羟基（可被取代）或氨基（可被取代），R2 是烷基（可被取代）时，具有抗耐药细菌的抗菌活性，因此可用作哺乳动物细菌感染的化疗药物。