4-amino-2-ethylisoxazolidin-3-one | 1013920-76-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 4-amino-2-ethylisoxazolidin-3-one
• 英文别名: (R)-4-amino-2-ethyl-isoxazolidin-3-one；(4R)-4-amino-2-ethyl-1,2-oxazolidin-3-one
• CAS: 1013920-76-7
• 化学式: C₅H₁₀N₂O₂
• 分子量: 130.147
• InChiKey: BCYJOUHCNAGXGJ-SCSAIBSYSA-N

物化性质

• 沸点：
  184.2±50.0 °C(Predicted)
• 密度：
  1.157±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  55.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (Z)-3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl 5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylate 、 4-amino-2-ethylisoxazolidin-3-one 在 N,N-二异丙基乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 (Z)-5-[5-fluoro-2-oxo-1,2-dihydro-indol-3-ylidenemethyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid ((R)-2-ethyl-3-oxo-isoxazolidin-4-yl)amide
  参考文献：
  名称：

  WO2008/33562

  摘要：

  公开号：
• 作为产物：
  描述：

  ((R)-2-ethyl-3-oxo-isoxazolidin-4-yl)-carbamic acid tert-butyl ester 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 生成 4-amino-2-ethylisoxazolidin-3-one
  参考文献：
  名称：

  WO2008/33562

  摘要：

  公开号：

文献信息

• [EN] PROCESS FOR THE PREPARATION OF SUBSTITUTED CYCLOSERINES<br/>[FR] PROCÉDÉ DE PRÉPARATION DE CYCLOSÉRINES SUBSTITUÉES
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：WO2015166094A1

  公开（公告）日：2015-11-05

  The present invention relates to processes for the preparation of substituted cycloserine compounds of formula (I) wherein R1 is C1-C8alkyl, C1-C8haloalkyl, C3-C6cycloalkyl,aryl or aryl substituted by one to five R11, or aryl-C1-C4alkylene or aryl-C1-C4alkylene substituted by one to five R11; and each R11 is independently C1-C4alkyl, C1-C4haloalkyl, C1-C4alkoxy, C1-C4haloalkoxy, cyano or halogen; The invention also relates to intermediates produced by the processes. Compounds of formula (I) are useful intermediates for the production of compounds in the agricultural and pharmaceutical fields.

  本发明涉及制备式(I)的取代环丝氨酸化合物的过程，其中R1为C1-C8烷基，C1-C8卤代烷基，C3-C6环烷基，芳基或被1至5个R11取代的芳基，或芳基-C1-C4烷基或被1至5个R11取代的芳基-C1-C4烷基；每个R11独立地为C1-C4烷基，C1-C4卤代烷基，C1-C4烷氧基，C1-C4卤代烷氧基，氰基或卤素；该发明还涉及由这些过程产生的中间体。式(I)的化合物是在农业和制药领域生产化合物的有用中间体。
• [EN] INSECTICIDAL COMPOUNDS<br/>[FR] COMPOSÉS INSECTICIDES
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：WO2012163959A1

  公开（公告）日：2012-12-06

  The present invention provides compounds of formula (I): wherein A1, A2, A3 and A4 are independently of one another C-H, C-R5, or nitrogen; B1--B2--B3--B4 is -CH2-C=N-CH2-, -CH2-N-CH2-CH2-, -CH2-C=CH-0- or -CH=C-CH2-0-; G1 is oxygen or sulfur; L is a single bond or C1-C8alkylene; R1 is hydrogen, C1-C8alkyl, C1-C8alkylcarbonyl-, C1-C8alkoxy, C2-C8alkenyl, C2-C8alkynyl, C1-C8alkoxy- C1-C8alkyl, aryl or aryl substituted by one to three R6, or R1 is heterocyclyl or heterocyclyl substituted by one to three R6 or C1-C8alkoxycarbonyl-; R2 is hydrogen, C1-C8haloalkyl or C1-C8alkyl; R3 is C1-C8haloalkyl; R4 is aryl or aryl substituted by one to three R6, or R4 is heterocyclyl or heterocyclyl substituted by one to three R6; Y1 is CR7R8, C=O or C=S; Y2, Y3 and Y4 are independently CR7R8, C=0, C=S, N-R9, O, S, SO or SO2; wherein at least two adjacent ring atoms in the ring formed by Y1, Y2, Y3 and Y4 are heteroatoms; each R7 and R8 is independently hydrogen, halogen, C1-C8alkyl, or C1-C8haloalkyl; and R5, R6, R7, R8 and R9 are as defined in the claims. The invention also relates to processes and intermediates for preparing these compounds, to insecticidal, acaricidal, nematicidal and molluscicidal compositions comprising these compounds and to methods of using these compounds to control insect, acarine, nematode and mollusc pests.

  本发明提供了以下式（I）的化合物：其中A1、A2、A3和A4彼此独立地为C-H、C-R5或氮；B1--B2--B3--B4为-CH2-C=N-CH2-、-CH2-N-CH2-CH2-、-CH2-C=CH-0-或-CH=C-CH2-0-；G1为氧或硫；L为单键或C1-C8烷基；R1为氢、C1-C8烷基、C1-C8烷基羰基、C1-C8烷氧基、C2-C8烯基、C2-C8炔基、C1-C8烷氧基-C1-C8烷基、芳基或被1至3个R6取代的芳基，或R1为杂环烷基或被1至3个R6或C1-C8烷氧羰基取代的杂环烷基；R2为氢、C1-C8卤代烷基或C1-C8烷基；R3为C1-C8卤代烷基；R4为芳基或被1至3个R6取代的芳基，或R4为杂环烷基或被1至3个R6取代的杂环烷基；Y1为CR7R8、C=O或C=S；Y2、Y3和Y4独立地为CR7R8、C=0、C=S、N-R9、O、S、SO或SO2；其中由Y1、Y2、Y3和Y4形成的环中至少有两个相邻的环原子为杂原子；每个R7和R8独立地为氢、卤素、C1-C8烷基或C1-C8卤代烷基；而R5、R6、R7、R8和R9如权利要求中所定义。本发明还涉及制备这些化合物的过程和中间体，包括这些化合物的杀虫剂、杀螨剂、杀线虫剂和杀软体动物剂组合物，以及使用这些化合物控制昆虫、螨类、线虫和软体动物害虫的方法。
• INSECTICIDAL COMPOUNDS BASED ON ISOAZOLINE DERIVATIVES
  申请人：Cassayre Jerome Yves

  公开号：US20120238517A1

  公开（公告）日：2012-09-20

  The present invention relates to compounds of formula (I): Wherein A 1 , A 2 , A 3 , A 4 , G 1 , L, Y 1 , Y 2 , Y 3 , Y 4 , R 1 , R 2 , R 3 and R 4 are as defined in claim 1 ; or a salt or N-oxide thereof. Furthermore, the present invention relates to intermediates for preparing compounds of formula (I), to compositions comprising them and to methods of using them to combat and control insect, acarine, nematode and mollusc pests.

  本发明涉及式(I)的化合物：其中A1、A2、A3、A4、G1、L、Y1、Y2、Y3、Y4、R1、R2、R3和R4如权利要求1所定义；或其盐或N-氧化物。此外，本发明涉及制备式(I)化合物的中间体，包含它们的组合物以及使用它们来对抗和控制昆虫、螨虫、线虫和软体动物害虫的方法。
• [EN] INSECTICIDAL COMPOUNDS BASED ON ISOXAZOLINE DERIVATIVES<br/>[FR] COMPOSÉS INSECTICIDES À BASE DE DÉRIVÉS ISOXAZOLINE
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：WO2011067272A1

  公开（公告）日：2011-06-09

  The present invention relates to compounds of formula (I): Wherein A1, A2, A3, A4, G1, L, Y1, Y2, Y3, Y4, R1, R2, R3 and R4 are as defined in claim 1; or a salt or N-oxide thereof. Furthermore, the present invention relates to intermediates for preparing compounds of formula (I), to compositions comprising them and to methods of using them to combat and control insect, acarine, nematode and mollusc pests.

  本发明涉及式(I)的化合物：其中A1、A2、A3、A4、G1、L、Y1、Y2、Y3、Y4、R1、R2、R3和R4如权利要求1所定义；或其盐或N-氧化物。此外，本发明涉及制备式(I)化合物的中间体，包含它们的组合物以及使用它们来对抗和控制昆虫、螨虫、线虫和软体动物害虫的方法。
• [EN] DIHYDROTHIOPHENE DERIVATIVES AS INSECTICIDAL COMPOUNDS<br/>[FR] DÉRIVÉS DE DIHYDROTHIOPHÈNE UTILISÉS COMME COMPOSÉS INSECTICIDES
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：WO2014072480A1

  公开（公告）日：2014-05-15

  The present invention provides compounds of formula (I) wherein Q is Q1 or Q2 P is P0, heterocyclyl or heterocyclyl substituted by one to five Z; Y1, Y2, Y3 and Y4 are independently of each other C-H, C-R5, or nitrogen; G1 is oxygen or sulfur; R1 is hydrogen, C1-C8alkyl, C1-C8alkoxy-, C1-C8alkylcarbonyl-, or C1-C8alkoxycarbonyl-; X4 is C1-C8haloalkyl; R4 is aryl or aryl substituted by one to five R9, or heteroaryl or heteroaryl substituted by one to five R9; n is 0, 1 or 2; and Z, R2, R5 and R9 are as defined in the claims. The invention also provides methods of controlling insects, acarines, nematodes or molluscs comprising applying to a pest, to a locus of a pest, or to a plant susceptible to attack by a pest an insecticidally, acaricidally, nematicidally or molluscicidally effective amount of a compound of formula (I).

  本发明提供了式（I）的化合物，其中Q是Q1或Q2，P是P0，杂环烷基或被1至5个Z取代的杂环烷基；Y1、Y2、Y3和Y4彼此独立地是C-H、C-R5或氮；G1是氧或硫；R1是氢、C1-C8烷基、C1-C8烷氧基、C1-C8烷基羰基或C1-C8烷氧羰基；X4是C1-C8卤代烷基；R4是芳基或被1至5个R9取代的芳基，或者是杂芳基或被1至5个R9取代的杂芳基；n为0、1或2；Z、R2、R5和R9的定义如权利要求中所述。该发明还提供了一种控制昆虫、螨虫、线虫或软体动物的方法，包括向害虫、害虫的生境或易受害虫侵袭的植物施加式（I）化合物的杀虫、杀螨、杀线虫或杀软体动物的有效量。