(Z)-1-(furan-2-yl)propan-1-one oxime | 116435-25-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 杂芳族化合物
• 英文名称: (Z)-1-(furan-2-yl)propan-1-one oxime
• 英文别名: 1-[2]furyl-propan-1-one-(Z)-oxime；1-[2]Furyl-propan-1-on-(Z)-oxim；(NZ)-N-[1-(furan-2-yl)propylidene]hydroxylamine
• CAS: 116435-25-7
• 化学式: C₇H₉NO₂
• 分子量: 139.154
• InChiKey: XGJQVGIPNVJZPT-VURMDHGXSA-N

物化性质

• 熔点：
  78 °C
• 沸点：
  234.4±13.0 °C(Predicted)
• 密度：
  1.12±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  45.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (Z)-1-(furan-2-yl)propan-1-one oxime 在 chiral amine C₁₇H₁₉NO 、 硼烷 、 sodium hydride 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 反应 51.0h， 生成 (R)-1-(furan-2-yl)propanamine
  参考文献：
  名称：

  呋喃-2-基胺和氨基酸的对映体的新型对映选择性合成

  摘要：

  描述了呋喃-2-基胺和氨基酸的一种新的对映选择性合成，其中关键步骤是恶唑硼烷催化的O-苄基（E）-和（Z）-呋喃-2-基酮肟的对映选择性还原。相应的手性胺。呋喃-2-基胺的手性通过的几何异构体的合适的选择完全控制ø -苄基肟。呋喃环的氧化以高产率提供了氨基酸。

  DOI：

  10.1002/hlca.200390022
• 作为产物：
  描述：

  1-(2-furyl)-1-propanone oxime 在 盐酸 作用下， 以 乙醚 为溶剂， 以68%的产率得到(Z)-1-(furan-2-yl)propan-1-one oxime
  参考文献：
  名称：

  呋喃-2-基胺和氨基酸的对映体的新型对映选择性合成

  摘要：

  描述了呋喃-2-基胺和氨基酸的一种新的对映选择性合成，其中关键步骤是恶唑硼烷催化的O-苄基（E）-和（Z）-呋喃-2-基酮肟的对映选择性还原。相应的手性胺。呋喃-2-基胺的手性通过的几何异构体的合适的选择完全控制ø -苄基肟。呋喃环的氧化以高产率提供了氨基酸。

  DOI：

  10.1002/hlca.200390022

文献信息

• Untersuchungen über furan-verbindungen—V
  作者：G. Ocskay、L. Vargha

  DOI：10.1016/0040-4020(58)88031-x

  日期：1958.1

  Several pairs of syn and anti-furyl-ketoximes have been prepared, which have been characterised by their acetates, benzoates and p-toluenesulphonates. The configurations of the ketoximes were successfully established by chemical means and by their u.v. spectra

  已经制备了几对顺式和反式-呋喃酮酮肟，其特征在于它们的乙酸盐，苯甲酸盐和对甲苯磺酸盐。通过化学方法及其紫外光谱成功建立了酮肟的构型
• ISOXAZOLOPYRIDINE DERIVATIVES FOR USE IN THE TREATMENT OF HIF-MEDIATED CONDITIONS
  申请人：Arend Michael P.

  公开号：US20100303928A1

  公开（公告）日：2010-12-02

  The present invention relates to novel compounds capable of modulating the stability and/or activity of hypoxia inducible factor (HIF) by inhibiting the activity of at least one HIF hydroxylase enzyme.

  本发明涉及一种新型化合物，能够通过抑制至少一种HIF羟化酶酶活性来调节缺氧诱导因子（HIF）的稳定性和/或活性。
• Non-toxic corrosion-protection pigments based on manganese
  申请人：——

  公开号：US20040011252A1

  公开（公告）日：2004-01-22

  Corrosion-inhibiting pigments based on manganese are described that contain a trivalent or tetravalent manganese/valence stabilizer complex. An inorganic or organic material is used to stabilize the trivalent or tetravalent manganese ion to form a compound that is sparingly soluble, exhibits low solubility, or is insoluble in water, depending upon the intended usage. Specific stabilizers are chosen to control the release rate of trivalent or tetravalent manganese during exposure to water and to tailor the compatibility of the powder when used as a pigment in a chosen binder system. Stabilizers may also modify the processing and handling characteristics of the formed powders. Manganese/valence stabilizer combinations are chosen based on the well-founded principles of manganese coordination chemistry. Many manganese-valence stabilizer combinations are presented that can equal the performance of conventional hexavalent chromium or tetravalent lead systems. It is emphasized that this abstract is provided to comply with the rules requiring an abstract which will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims.

  以锰为基础的缓蚀颜料含有三价或四价锰/价稳定剂复合物。一种无机或有机材料可用于稳定三价或四价锰离子，从而形成一种可少量溶解、溶解度低或不溶于水的化合物，具体取决于预期用途。选择特定的稳定剂是为了控制三价锰或四价锰在遇水时的释放率，并调整粉末在所选粘合剂体系中用作颜料时的相容性。稳定剂还可以改变成型粉末的加工和处理特性。锰/价稳定剂组合的选择是基于锰配位化学的基本原理。文中介绍了许多锰价稳定剂组合，其性能与传统的六价铬或四价铅体系相当。需要强调的是，提供本摘要是为了符合要求提供摘要的规则，以便检索者或其他读者快速确定技术公开的主题。提交本摘要的前提是，本摘要不用于解释或限制权利要求的范围或含义。
• Non-toxic corrosion-protection pigments based on rare earth elements
  申请人：——

  公开号：US20040104377A1

  公开（公告）日：2004-06-03

  A corrosion-inhibiting pigment comprising a rare earth element and a valence stabilizer combinded to form a rare earth/valence stabilizer complex. The rare earth element is selected from cerium, terbium, praseodymium, or a combination thereof, and at least one rare earth element is in the tetravalent oxidation state. An inorganic or organic material is used to stabilize the tetravalent rare earth ion to form a compound that is sparingly soluble in water. Specific stabilizers are chosen to control the release rate of tetravalent cerium, terbium, or praseodymium during exposure to water and to tailor the compatibility of the powder when used as a pigment in a chosen binder system. Stabilizers may also modify the processing and handling characteristics of the formed powders. Many rare earth-valence stabilizer combinations are presented that can equal the performance of conventional hexavalent chromium systems.

  一种缓蚀颜料，由稀土元素和价态稳定剂结合形成稀土/价态稳定剂复合物。稀土元素选自铈、铽、镨或它们的组合，至少有一种稀土元素处于四价氧化态。使用无机或有机材料来稳定四价稀土离子，以形成稀溶于水的化合物。选择特定的稳定剂是为了控制四价铈、铽或镨在遇水时的释放率，并调整粉末在所选粘合剂体系中用作颜料时的相容性。稳定剂还可以改变成型粉末的加工和处理特性。本文介绍了许多稀土-价稳定剂组合，其性能可与传统的六价铬体系媲美。
• Studies on Furan Compounds. IV. Reactions of the p-Toluenesulfonyl Derivatives of Several Furylketoximes with Alcohols
  作者：L. Vargha、F. Gönczy

  DOI：10.1021/ja01162a110

  日期：1950.6