[(1R)-1-[benzyl-[(2-methylpropan-2-yl)oxycarbonyl]amino]-1-phenylbut-3-en-2-yl] ethyl carbonate | 201055-40-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [(1R)-1-[benzyl-[(2-methylpropan-2-yl)oxycarbonyl]amino]-1-phenylbut-3-en-2-yl] ethyl carbonate
• CAS: 201055-40-5
• 化学式: C₂₅H₃₁NO₅
• 分子量: 425.525
• InChiKey: ZUUAPUYDBQITON-FOIFJWKZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  31
• 可旋转键数：
  12
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  65.1
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  丙醛 、 [(1R)-1-[benzyl-[(2-methylpropan-2-yl)oxycarbonyl]amino]-1-phenylbut-3-en-2-yl] ethyl carbonate 生成 (Z)-1-amino-1-phenyl-2-pentene
  参考文献：
  名称：

  Synthesis of chiral allyltitaniums having an amino group at the C-4 position and their diastereoselective addition reaction with aldehydes

  摘要：

  Chiral allyltitaniums having an amino substituent at the C-4 position are prepared from optically active allylic alcohol derivatives 1 and Ti(O-i-Pr)(4)/2i-PrMgCl reagent, which, in turn, react with aldehydes regio-and stereoselectively to afford 3-amino-2-vinylalkanols in excellent yields. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(97)10367-7
• 作为产物：
  描述：

  苯基甘油醇 在 titanium(IV) isopropylate 、 碳酸氢钠 作用下， 以 四氢呋喃 为溶剂， 生成 [(1R)-1-[benzyl-[(2-methylpropan-2-yl)oxycarbonyl]amino]-1-phenylbut-3-en-2-yl] ethyl carbonate
  参考文献：
  名称：

  Synthesis of chiral allyltitaniums having an amino group at the C-4 position and their diastereoselective addition reaction with aldehydes

  摘要：

  Chiral allyltitaniums having an amino substituent at the C-4 position are prepared from optically active allylic alcohol derivatives 1 and Ti(O-i-Pr)(4)/2i-PrMgCl reagent, which, in turn, react with aldehydes regio-and stereoselectively to afford 3-amino-2-vinylalkanols in excellent yields. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(97)10367-7