N-(1-acetamidoethenyl)acetamide | 162786-43-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-(1-acetamidoethenyl)acetamide
• CAS: 162786-43-8
• 化学式: C₆H₁₀N₂O₂
• 分子量: 142.158
• InChiKey: PSZHHAHVDIBTCX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-(1-acetamidoethenyl)acetamide 、 2-氟苯甲醛 反应 24.0h， 生成
  参考文献：
  名称：

  Tailoring the Structure of Aminobisphosphonates To Target Plant P5C Reductase

  摘要：

  Using the structure of (3,5-dichlorophenyl)aminomethylenebisphosphonic acid as a lead compound, 25 new phosphonates were synthesized and evaluated as possible inhibitors of Arabidopsis thaliana delta(1)-pyrroline-5-carboxylate (P5C) reductase. Derivatives substituted in the phenyl ring retained the inhibitory potential, though to a different extent. On the contrary any variation in the scaffold, i.e., the replacement of the second phosphonate moiety with a hydroxyl or an amino residue, resulted in a significant loss of biological activity. The availability of several structures capable of interfering with the catalytic mechanism in the micromolar to millimolar range allowed a proper structure-activity relationship analysis, leading us to hypothesize about the steric and electronic requirements for maintenance or enhancement of the inhibitory properties. Reversal experiments with suspension cultured cells provided evidence for the occurrence of enzyme inhibition in vivo. Because in higher plants the step catalyzed by P5C reductase is shared by all pathways leading to proline synthesis, these compounds may be exploited for the design of new substances endowed with herbicidal activity.

  DOI：

  10.1021/jf800029t
• 作为产物：
  描述：

  乙酰胺 、 乙酰氯 在 溶剂黄146 作用下， 反应 0.25h， 生成 N-(1-acetamidoethenyl)acetamide
  参考文献：
  名称：

  Tailoring the Structure of Aminobisphosphonates To Target Plant P5C Reductase

  摘要：

  Using the structure of (3,5-dichlorophenyl)aminomethylenebisphosphonic acid as a lead compound, 25 new phosphonates were synthesized and evaluated as possible inhibitors of Arabidopsis thaliana delta(1)-pyrroline-5-carboxylate (P5C) reductase. Derivatives substituted in the phenyl ring retained the inhibitory potential, though to a different extent. On the contrary any variation in the scaffold, i.e., the replacement of the second phosphonate moiety with a hydroxyl or an amino residue, resulted in a significant loss of biological activity. The availability of several structures capable of interfering with the catalytic mechanism in the micromolar to millimolar range allowed a proper structure-activity relationship analysis, leading us to hypothesize about the steric and electronic requirements for maintenance or enhancement of the inhibitory properties. Reversal experiments with suspension cultured cells provided evidence for the occurrence of enzyme inhibition in vivo. Because in higher plants the step catalyzed by P5C reductase is shared by all pathways leading to proline synthesis, these compounds may be exploited for the design of new substances endowed with herbicidal activity.

  DOI：

  10.1021/jf800029t

文献信息

• Polyamine polymers
  申请人：Chang Han Ting

  公开号：US20050165190A1

  公开（公告）日：2005-07-28

  The present invention provides polymeric and pharmaceutical compositions comprising a polymer that contains vicinal amine moieties, referred to as polyvicinalamine polymers. The polyvicinalamines can be copolymers or homopolymers. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of renal diseases, hyperphosphatemia, and the removal of bile acids; oxalates and iron from the gastrointestinal tract.

  本发明提供了包含邻胺官能团的高分子和药物组合物，称为聚邻胺高分子。聚邻胺可以是共聚物或均聚物。本文还披露了用于治疗和/或预防疾病的高分子和药物组合物的使用方法。这些方法的例子包括治疗肾脏疾病、高磷血症以及从胃肠道中去除胆汁酸、草酸盐和铁。
• Stabilized monomer compositions
  申请人：CIBA-GEIGY AG

  公开号：EP0467851A1

  公开（公告）日：1992-01-22

  A process for stabilizing an ethylenically unsaturated monomer or oligomer from premature polymerization is disclosed whereby a stabilizing amount of an N-hydrocarbyloxy substituted hindered amine is added to said polymerizable monomer or oligomer. The ethylenically unsaturated monomer or oligomer encompass vinyl monomers or oligomers bearing at least one polymerizable moiety. The N-hydrocarbyloxy substituted hindered amine inhibits premature polymerization in the liquid and/or vapor phase.

  本发明揭示了一种稳定乙烯基不饱和单体或低聚物以防止其过早聚合的过程，其中向可聚合的单体或低聚物中加入一定量的N-烷氧基取代的受阻胺。乙烯基不饱和单体或低聚物包括至少带有一种可聚合基团的乙烯基单体或低聚物。N-烷氧基取代的受阻胺在液体和/或气相中抑制过早聚合。
• Stabilisierung von Metalleffekteinbrennlacken gegen die Einwirkung von Licht, Feuchtigkeit und Sauerstoff durch den Zusatz von Polyalkylpiperidinderivaten
  申请人：CIBA-GEIGY AG

  公开号：EP0002753A2

  公开（公告）日：1979-07-11

  Verwendung von 2,2,6,6-Tetraalkylpiperidinverbindungen, ihren Säureadditionssalzen oder Komplexen mit Metallverbindungen, gegebenenfalls zusammen mit weiteren Stabilisatoren zum Stabilisieren von Metalleffekteinbrennlacken auf der Basis heißvernetzbarer Atkyd- oder Acryiharze gegen die Einwirkung von Licht, Feuchtigkeit und Sauerstoff.

  使用 2,2,6,6-四烷基哌啶化合物、其酸加成盐或与金属化合物的络合物，可选择与其他稳定剂一起使用，以稳定基于热交联醇酸树脂或丙烯酸树脂的金属效果搪瓷，使其免受光、湿气和氧气的作用。
• Lichtstabilisierung von sauerkatalysierten Einbrennlacken
  申请人：CIBA-GEIGY AG

  公开号：EP0006213A1

  公开（公告）日：1980-01-09

  Verwendung von N-substituierten 2,2,6,6-Tetraaikylpiperidinverbindungen, ihren Säureadditionssalzen oder Komplexen mit Metallverbindungen, gegebenenfalls zusammen mit weiteren Stabilisatoren zum Stabilisieren von sauerkatalysierten Einbrennlacken auf der Basis heissvernetzbarer Acryl-, Polyester- oder Alkydharze gegen die Enwirkung von Licht, Feuchtigkeit und Sauerstoff.

  使用 N-取代的 2,2,6,6-四太烷基哌啶化合物、其酸加成盐或与金属化合物的络合物，可选择与进一步的稳定剂一起使用，以稳定基于可热交联丙烯酸树脂、聚酯树脂或醇酸树脂的酸催化脱色漆，防止光、湿气和氧气的影响。
• 2-(2-Hydroxy-3.5-disubstituiertes-phenyl)-2H-benzotriazol und damit stabilisierte Mischungen
  申请人：CIBA-GEIGY AG

  公开号：EP0006564A2

  公开（公告）日：1980-01-09

  Verbindungen der Formel worin T, Wasserstoff oder Chlor ist, T2 und T3 unabhängig voneinander die Gruppe bedeuten, worin T4 Wasserstoff oder niedriges Alkyl ist, wobei eines von T2 und T3 auch t-Octyl sein kann, als Lichtschutzmittel für organisches Material, Verfahren zu ihrer Herstellung, das mit ihnen ausgerüstete organische Material, insbesondere mit ihnen ausgerüsteter Lack.

  式中 T 为氢或氯，T2 和 T3 相互独立地为 T4 为氢或低级烷基的基团，T2 和 T3 中也可以有一个是 t-辛基，作为有机材料的光稳定剂，其制备工艺，用其处理的有机材料，特别是用其处理的漆。