2-Propenoic acid, 3-phenyl-2-[(trimethylsilyl)oxy]-, ethyl ester | 88089-53-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Propenoic acid, 3-phenyl-2-[(trimethylsilyl)oxy]-, ethyl ester
• 英文别名: ethyl 3-phenyl-2-trimethylsilyloxyprop-2-enoate
• CAS: 88089-53-6
• 化学式: C₁₄H₂₀O₃Si
• 分子量: 264.397
• InChiKey: XXBBCKJJSCCTIZ-UHFFFAOYSA-N

物化性质

• 沸点：
  315.4±35.0 °C(Predicted)
• 密度：
  1.023±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.44
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-nitrobenzenesulfonyl peroxide 、 2-Propenoic acid, 3-phenyl-2-[(trimethylsilyl)oxy]-, ethyl ester 以 乙酸乙酯 为溶剂， 反应 4.0h， 以81%的产率得到ethyl 3-[(p-nitrobenzenesulfonyl)oxy]-2-oxo-4-phenylbutanoate
  参考文献：
  名称：

  Synthesis and Reactions of 3-(Nosyloxy)-2-keto Esters

  摘要：

  A series of 3-(nosyloxy)-2-keto esters 7a-j were prepared from the corresponding cr-keto esters by conversion to the trimethylsilyl enol ether and reaction with p-nitrobenzenesulfonyl peroxide. Conversion of these materials to 1,2,3-trifunctionalized compounds is described, and comparison of their properties with isomeric 2-(nosyloxy)-3-keto esters is discussed.

  DOI：

  10.1021/jo962206h
• 作为产物：
  描述：

  三甲基氯硅烷 、 2-氧代-4-苯基丁酸乙酯 以 四氢呋喃 、 三乙胺 为溶剂， 以89%的产率得到2-Propenoic acid, 3-phenyl-2-[(trimethylsilyl)oxy]-, ethyl ester
  参考文献：
  名称：

  Synthesis and Reactions of 3-(Nosyloxy)-2-keto Esters

  摘要：

  A series of 3-(nosyloxy)-2-keto esters 7a-j were prepared from the corresponding cr-keto esters by conversion to the trimethylsilyl enol ether and reaction with p-nitrobenzenesulfonyl peroxide. Conversion of these materials to 1,2,3-trifunctionalized compounds is described, and comparison of their properties with isomeric 2-(nosyloxy)-3-keto esters is discussed.

  DOI：

  10.1021/jo962206h

文献信息

• Synthesis and Reactions of 3-(Nosyloxy)-2-keto Esters
  作者：Robert V. Hoffman、M. Catherine Johnson、John F. Okonya

  DOI：10.1021/jo962206h

  日期：1997.4.1

  A series of 3-(nosyloxy)-2-keto esters 7a-j were prepared from the corresponding cr-keto esters by conversion to the trimethylsilyl enol ether and reaction with p-nitrobenzenesulfonyl peroxide. Conversion of these materials to 1,2,3-trifunctionalized compounds is described, and comparison of their properties with isomeric 2-(nosyloxy)-3-keto esters is discussed.