3-ethoxycarbonylmethyl-5-methyl-pyrrole-2,4-dicarboxylic acid-2-ethyl ester-4-tert-butyl ester | 107044-69-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 3-ethoxycarbonylmethyl-5-methyl-pyrrole-2,4-dicarboxylic acid-2-ethyl ester-4-tert-butyl ester
• 英文别名: 3-ethoxycarbonylmethyl-5-methyl-pyrrole-2,4-dicarboxylic acid-2-ethyl ester-4-tert-butyl ester；3-Aethoxycarbonylmethyl-5-methyl-pyrrol-2,4-dicarbonsaeure-2-aethylester-4-tert-butylester
• CAS: 107044-69-9
• 化学式: C₁₇H₂₅NO₆
• 分子量: 339.389
• InChiKey: NIIQDYCKFKGLMC-UHFFFAOYSA-N

物化性质

• 熔点：
  117.5 °C
• 沸点：
  478.7±45.0 °C(Predicted)
• 密度：
  1.149±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.56
• 重原子数：
  24.0
• 可旋转键数：
  6.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  94.69
• 氢给体数：
  1.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  2,4-二甲基-3-吡咯羧酸乙酯 、 3-ethoxycarbonylmethyl-5-methyl-pyrrole-2,4-dicarboxylic acid-2-ethyl ester-4-tert-butyl ester 在 氯仿 、 三氯氧磷 作用下， 生成 2,4,2',4'-tetramethyl-5,5'-(5-ethoxycarbonyl-4-ethoxycarbonylmethyl-2-methyl-pyrrol-3-ylidenemethanediyl)-bis-pyrrole-3-carboxylic acid diethyl ester
  参考文献：
  名称：

  Treibs; Hintermeier, Justus Liebigs Annalen der Chemie, 1957, vol. 605, p. 35,42

  摘要：

  DOI：
• 作为产物：
  描述：

  1,3-丙酮二羧酸二乙酯 、 亚硝酸异戊酯 在 盐酸 作用下， 生成 3-ethoxycarbonylmethyl-5-methyl-pyrrole-2,4-dicarboxylic acid-2-ethyl ester-4-tert-butyl ester
  参考文献：
  名称：

  What Happens to the State in Conflict?: Political Analysis as a Tool for Planning Humanitarian Assistance

  摘要：

  It is now part of received wisdom that humanitarian assistance in conflict and post‐conflict situations may be ineffective or even counterproductive in the absence of an informed understanding of the broader political context in which so‐called ‘complex political emergencies’ (CPEs) occur. Though recognising that specific cases have to be understood in their own terms, this article offers a framework for incorporating political analysis in policy design. It is based on a programme of research on a number of countries in Africa and Asia over the last four years. It argues that the starting‐point should be an analysis of crises of authority within contemporary nation‐states which convert conflict (a feature of all political systems) into violent conflict; of how such conflict may in turn generate more problems for, or even destroy, the state; of the deep‐rooted political, institutional and developmental legacies of political violence; and of the difficulties that complicate the restoration of legitimate and effective systems of governance after the ‘termination’ of conflict. It then lists a series of questions which such an analysis would need to ask — less in order to provide a comprehensive check‐list than to uncover underlying political processes and links. It is hoped these may be used not only to understand the political dynamics of emergencies, but also to identify what kinds of policy action should and should not be given priority by practitioners.

  DOI：

  10.1111/1467-7717.00150

文献信息

• Alkylation of substituted pyrrole dianions; Synthetic studies directed at the B/C ring systems of CC-1065
  作者：Thomas A. Bryson、Gary A. Roth、Liu Jing-hau

  DOI：10.1016/s0040-4039(00)83853-8

  日期：1986.1

  The dianion chemistry of pyrroles is investigated using several alkylating agents. Inter-followed by intramolecular alkylation with dibromoethane affords cyclopropylpyrroles 7–10.

  使用几种烷基化剂研究了吡咯的二价阴离子化学。与二溴乙烷进行分子内烷基化反应后得到环丙基吡咯7-10。