1-(2-乙氧基苯基)环丙烷-1-羧酸 | 74205-25-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 1-(2-乙氧基苯基)环丙烷-1-羧酸
• 英文名称: 1-(2-Ethoxyphenyl)cyclopropane-1-carboxylic acid
• CAS: 74205-25-7
• 化学式: C₁₂H₁₄O₃
• 分子量: 206.241
• InChiKey: OXINQESZYKYUFY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-(2-乙氧基苯基)环丙烷-1-羧酸 在 碳酸氢钠 、 三乙胺 作用下， 以 丙酮 为溶剂， 反应 6.0h， 生成 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((1-(2-ethoxyphenyl)cyclopropyl)carbonyl)amino)-3-methyl-8-oxo-, (6R-trans)-
  参考文献：
  名称：

  Synthesis and antibacterial activity of 1-alkoxyphenylcycloalkyl-1-deacetoxycephalosporins

  摘要：

  DOI：

  10.1007/bf00765109
• 作为产物：
  描述：

  (2-乙氧基苯)乙腈 在 氢氧化钾 、 sodium amide 作用下， 以 二乙二醇 为溶剂， 反应 15.0h， 生成 1-(2-乙氧基苯基)环丙烷-1-羧酸
  参考文献：
  名称：

  Semisynthetic penicillins. XIII. 1-Alkoxyphenylcyclopropyl- and cyclobutyl-penicillins

  摘要：

  DOI：

  10.1007/bf00765910

文献信息

• Benzofurane and benzothiophene derivatives as PGE2 receptor modulators
  申请人：IDORSIA PHARMACEUTICALS LTD

  公开号：US11325899B2

  公开（公告）日：2022-05-10

  The present invention relates to benzofurane and benzothiophene derivatives of formula (I) wherein (R1)n, R2, R3, R4a, R4b, R5a, R5b and Ar1 are as described in the description and their use in the treatment of cancer by modulating an immune response comprising a reactivation of the immune system in the tumor. The invention further relates to novel benzofurane and benzothiophene derivatives of formula (II) and their use as pharmaceuticals, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as modulators of the prostaglandin 2 receptors EP2 and/or EP4.

  本发明涉及式 (I) 的苯并呋喃和苯并噻吩衍生物 其中(R1)n、R2、R3、R4a、R4b、R5a、R5b 和 Ar1 如说明书所述，以及它们通过调节免疫反应（包括重新激活肿瘤中的免疫系统）治疗癌症的用途。本发明进一步涉及式(II)的新型苯并呋喃和苯并噻吩衍生物及其作为药物的用途、它们的制备、它们的药学上可接受的盐及其作为药物的用途、含有一种或多种式(I)化合物的药物组合物，特别是它们作为前列腺素2受体EP2和/或EP4的调节剂的用途。
• 7-Aminocephalosporamic acid derivatives and their antibacterial properties
  作者：Sh. L. Mndzhoyan、M. S. Kramer、M. V. Aleksanyan、Yu. Z. Ter-Zakharyan、Sh. G. Oganyan、R. V. Agababyan

  DOI：10.1007/bf00769654

  日期：1988.5
• BENZOFURANE AND BENZOTHIOPHENE DERIVATIVES AS PGE2 RECEPTOR MODULATORS
  申请人：IDORSIA PHARMACEUTICALS LTD

  公开号：US20210115031A1

  公开（公告）日：2021-04-22

  The present invention relates to benzofurane and benzothiophene derivatives of formula (I) wherein (R 1 ) n , R 2 , R 3 , R 4a , R 4b , R 5a , R 5b and Ar 1 are as described in the description and their use in the treatment of cancer by modulating an immune response comprising a reactivation of the immune system in the tumor. The invention further relates to novel benzofurane and benzothiophene derivatives of formula (II) and their use as pharmaceuticals, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as modulators of the prostaglandin 2 receptors EP2 and/or EP4.