2-(2-Iodo-thiophen-3-yl)-ethanol | 187791-42-0

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 芳基卤化物
• 英文名称: 2-(2-Iodo-thiophen-3-yl)-ethanol
• 英文别名: 2-(2-Iodothiophen-3-yl)ethanol
• CAS: 187791-42-0
• 化学式: C₆H₇IOS
• 分子量: 254.091
• InChiKey: NGZDENGIVJPWEA-UHFFFAOYSA-N

物化性质

• 沸点：
  293.2±25.0 °C(Predicted)
• 密度：
  1.935±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  48.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(2-Iodo-thiophen-3-yl)-ethanol 在 [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride 吡啶 、 potassium carbonate 作用下， 以 甲醇 、 氯仿 、 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 反应 23.17h， 生成 tert-butyl N-[2-(2-{5-[3-(2-{bis[(tert-butoxy)carbonyl]amino}ethyl)thiophen-2-yl]thiophen-2-yl}thiophen-3-yl)ethyl]-N-[(tert-butoxy)carbonyl]carbamate
  参考文献：
  名称：

  NOVEL THIOPHENE COMPOUNDS FOR USE IN THERAPY

  摘要：

  本发明涉及一种新型取代噻吩衍生物，在治疗与错折和聚集蛋白相关的疾病方面具有用途。

  公开号：

  US20120157516A1
• 作为产物：
  描述：

  噻吩-3-乙醇 在 N-碘代丁二酰亚胺 、 溶剂黄146 作用下， 以 氯仿 为溶剂， 反应 3.0h， 生成 2-(2-Iodo-thiophen-3-yl)-ethanol
  参考文献：
  名称：

  [EN] OLIGOTHIOPHENE DERIVATE AS MOLECULAR PROBES
  [FR] DÉRIVÉS D'OLIGOTHIOPHÈNE UTILISÉS COMME SONDES MOLÉCULAIRES

  摘要：

  本发明涉及与神经干细胞和神经癌干细胞特异性结合的寡噻吩衍生物。更具体地，本发明涉及使用所述寡噻吩衍生物在生物样品中检测神经干细胞或神经癌干细胞的方法，以及与之相关的用途和试剂盒。

  公开号：

  WO2011102789A1

文献信息

• Development of synthetic routes to macrocyclic compounds based on the HSP90 inhibitor radicicol
  作者：Butrus Atrash、Tracey S. Cooper、Peter Sheldrake、Paul Workman、Edward McDonald

  DOI：10.1016/j.tetlet.2006.01.116

  日期：2006.3

  Short routes are reported to novel macrolides (e.g., 9, 12, 20) related to the HSP90 inhibitor radicicol.

  短路线被报告给新的大环内酯（例如，9，12，20）与所述HSP90抑制剂根赤壳菌素。
• [EN] NOVEL THIOPHENE COMPOUNDS FOR USE IN THERAPHY<br/>[FR] NOUVEAUX COMPOSÉS DU THIOPHÈNE THÉRAPEUTIQUES
  申请人：BIOCHROMIX PHARMA AB

  公开号：WO2010044743A1

  公开（公告）日：2010-04-22

  The present invention relates to novel substituted thiophene derivatives useful in therapy of diseases related to misfolded and aggregated proteins.

  本发明涉及新型取代噻吩衍生物，用于治疗与蛋白质错折和聚集相关的疾病。
• Rapid Syntheses of Oligo(2,5-thiophene ethynylene)s with Thioester Termini:  Potential Molecular Scale Wires with Alligator Clips
  作者：Darren L. Pearson、James M. Tour

  DOI：10.1021/jo962335y

  日期：1997.3.1

  The syntheses of soluble oligo(3-ethyl-2,5-thiophene ethynylene)s via an iterative divergent/convergent approach starting from 3-ethyl-2-(trimethylsilylethynyl)thiophene are described. The monomer, dimer, tetramer, octamer, and 16-mer were synthesized. The 16-mer is 100 Angstrom long in its minimized extended zigzag conformation. At each stage in the iteration, the length of the framework doubles. Only three sets of reaction conditions are needed for the entire iterative synthetic sequence: an iodination, a protodesilylation, and a Pd/Cu-catalyzed cross coupling. The oligomers were characterized spectroscopically and by mass spectrometry. The optical properties are presented which show that at the octamer stage, the optical absorbance maximum is nearly saturated. The size exclusion chromatography values for the number average weights, relative to polystyrene, illustrate the tremendous differences in the hydrodynamic volume of these rigid rod oligomers verses the random coils of polystyrene. These differences become quite apparent at the octamer stage. Attachment of thiol end groups, protected as the thioacetyl moieties, was achieved. These serve as binding sites for adhesion to gold surfaces. In some cases, one end of the oligomeric chains were capped with a thiol group so that the surface attachments to gold could be studied. In other cases, thiol groups were affixed to both ends of the molecular chains so that future conduction studies could be done between proximal metallic probes. The rigid rod conjugated oligomers may act as molecular wires in molecular scale electronic devices, and they also serve as useful models for understanding analogous bulk polymers.
• NOVEL THIOPHENE COMPOUNDS FOR USE IN THERAPHY
  申请人：CPL BCX PHARMA AB

  公开号：EP2350042B1

  公开（公告）日：2015-07-29
• OLIGOTHIOPHENE DERIVATE AS MOLECULAR PROBES
  申请人：Celluminova AB

  公开号：EP2536712B1

  公开（公告）日：2015-03-18