4-butyl-phenethylamine | 743355-59-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-butyl-phenethylamine
• 英文别名: 4-Butyl-phenaethylamin；2-(4-Butylphenyl)ethanamine
• CAS: 743355-59-1
• 化学式: C₁₂H₁₉N
• 分子量: 177.29
• InChiKey: ZWVAEXGUCYEOBM-UHFFFAOYSA-N

物化性质

• 沸点：
  141-148 °C(Press: 21 Torr)
• 密度：
  0.924±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-butyl-phenethylamine 在 三氯化铝 、 硝基苯 、 甲苯 作用下， 生成 7-butyl-3,4-dihydro-2H-isoquinolin-1-one
  参考文献：
  名称：

  Anderson et al., Journal of the American Pharmaceutical Association (1912), 1952, vol. 41, p. 643,648

  摘要：

  DOI：
• 作为产物：
  描述：

  1-丁基-4-(氯甲基)苯 在 乙醇 、 氨 、 镍 作用下， 生成 4-butyl-phenethylamine
  参考文献：
  名称：

  Anderson et al., Journal of the American Pharmaceutical Association (1912), 1952, vol. 41, p. 643,648

  摘要：

  DOI：

文献信息

• Diprovocims: a new and potent class of TLR agonists
  申请人：The Scripps Research Institute

  公开号：US11040959B2

  公开（公告）日：2021-06-22

  A diprovocim compound that corresponds in structure to structural Formula V is disclosed, wherein A, W, Z, R1, R2, R3 and R4 (when present) are defined within. A diprovocim compound has immune-adjuvant properties on human and mouse cells in culture and on in vivo immunization of mice. A composition containing a diprovocim and a method of using a compound are also disclosed. The immunostimulatory activity of a diprovocim compound is similar to that of LPS, to which there is no apparent structural similarity. A contemplated compound bears no structural similarity to either the TLR1/TLR2 lipoprotein agonists nor to any other synthetic TLR agonist, and is remarkably easy to prepare and synthetically modify.

  本发明公开了一种在结构上与结构式 V 相对应的二鸦胆子苷化合物，其中 A、W、Z、R1、R2、R3 和 R4（当存在时）在结构式 V 中定义。一种双缩脲化合物对培养中的人和小鼠细胞以及小鼠体内免疫具有免疫佐剂特性。此外，还公开了一种含有二丙烯酰菌胺的组合物和一种化合物的使用方法。一种二丙烯酰氨化合物的免疫刺激活性与 LPS 相似，而 LPS 与二丙烯酰氨化合物没有明显的结构相似性。一种设想的化合物与 TLR1/TLR2 脂蛋白激动剂或任何其他合成的 TLR 激动剂都没有结构相似性，而且非常容易制备和合成修饰。
• DE1012605
  申请人：——

  公开号：——

  公开（公告）日：——
• Method for the preparation of tetrahydroisoquinolone derivatives
  申请人：SMITH KLINE FRENCH LAB

  公开号：US02647902A1

  公开（公告）日：1953-08-04
• METHOD FOR PRODUCING CYCLOPLATINIZED PLATINUM COMPLEXES, PLATINUM COMPLEXES PRODUCED BY SAID METHOD, AND THE USE THEREOF
  申请人：Englert Ullrich

  公开号：US20100267977A1

  公开（公告）日：2010-10-21

  The present invention relates to a process for preparing cycloplatinated platinum(II) complexes, platinum(II) complexes prepared by this process and the use thereof for the treatment of tumor diseases and/or hemo blastoses.
• DIPROVOCIMS: A NEW AND POTENT CLASS OF TLR AGONISTS
  申请人：BEUTLER Bruce

  公开号：US20200207742A1

  公开（公告）日：2020-07-02

  A diprovocim compound that corresponds in structure to structural Formula V is disclosed, wherein A, W, Z, R 1 , R 2 , R 3 and R 4 (when present) are defined within. A diprovocim compound has immune-adjuvant properties on human and mouse cells in culture and on in vivo immunization of mice. A composition containing a diprovocim and a method of using a compound are also disclosed. A The immunostimulatory activity of a diprovocim compound is similar to that of LPS, to which there is no apparent structural similarity. A contemplated compound bears no structural similarity to either the TLR1/TLR2 lipoprotein agonists nor to any other synthetic TLR agonist, and is remarkably easy to prepare and synthetically modify.