2,4-dioxo-hexanoic acid | 4383-93-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 酮酸及其衍生物
• 英文名称: 2,4-dioxo-hexanoic acid
• 英文别名: 2,4-Dioxo-hexansaeure；α,γ-Dioxo-n-capronsaeure；Propionylbrenztraubensaeure；2,4-Dioxohexanoic acid
• CAS: 4383-93-1
• 化学式: C₆H₈O₄
• mdl: MFCD19228446
• 分子量: 144.127
• InChiKey: NHHNHTOJLYTZLF-UHFFFAOYSA-N

物化性质

• 沸点：
  248.8±23.0 °C(Predicted)
• 密度：
  1.237±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  71.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2,4-dioxo-hexanoic acid 、 2,4-二硝基苯肼 在 盐酸 作用下， 生成 5-ethyl-1-(2,4-dinitro-phenyl)-1H-pyrazole-3-carboxylic acid
  参考文献：
  名称：

  Wage and Technology Dispersion

  摘要：

  This paper explains why firms with identical opportunities may use different technologies and offer different wages. Our key assumption is that workers must engage in costly search in order to gather information about jobs (Stigler (1961)). In equilibrium, some firms adopt high fixed cost, high productivity technologies, offer high wages, and fill job openings quickly. Other firms adopt less capital-intensive technologies and offer low wages, hiring mostly uninformed workers. In equilibrium, the amount of wage dispersion leaves workers indifferent about whether to gather information, and the fraction of informed workers leaves firms indifferent about their wage and technology choice. We show that worker search, which would appear to be a rent-seeking activity in partial equilibrium, may be efficiency-enhancing in general equilibrium.

  DOI：

  10.1111/1467-937x.00146
• 作为产物：
  描述：

  2,4-二氧代己酸乙酯 在 盐酸 作用下， 生成 2,4-dioxo-hexanoic acid
  参考文献：
  名称：

  Diels; Sielisch; Mueller, Chemische Berichte, 1906, vol. 39, p. 1337

  摘要：

  DOI：

文献信息

• [EN] PYRROLO-PYRROLE CARBAMATE AND RELATED ORGANIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND MEDICAL USES THEREOF<br/>[FR] COMPOSÉS DE PYRROLO-PYRROLE CARBAMATE ET COMPOSÉS ORGANIQUES ASSOCIÉS, COMPOSITIONS PHARMACEUTIQUES ET LEURS UTILISATIONS MÉDICALES
  申请人：ABIDE THERAPEUTICS INC

  公开号：WO2015003002A1

  公开（公告）日：2015-01-08

  The invention provides pyrrolo-pyrrole carbamate and related organic compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat medical disorders, e.g., solid tumor cancer, obesity, Down's syndrome, Alzheimer's disease, or pain, in a patient. The octahydropyrrolo pyrrole carbamates could be derived from hexafluoroisopropanol, Ν,Ν-disuccinimide and such. The activity of carbamates in MAGL, FAAH, and ABHD6 assays are also described.

  这项发明提供了吡咯-吡咯氨基甲酸酯及相关有机化合物，含有这些化合物的组合物，医疗工具包，以及使用这些化合物和组合物治疗患者的方法，例如固体肿瘤癌症、肥胖症、唐氏综合征、阿尔茨海默病或疼痛。八氢吡咯-吡咯氨基甲酸酯可以由六氟异丙醇、Ν,Ν-二琥珀酰亚胺等物质衍生而来。此外还描述了氨基甲酸酯在MAGL、FAAH和ABHD6测定中的活性。
• TRANSESTERIFICATION PROCESS USING MIXED SALT ACETYLACETONATES CATALYSTS
  申请人：Goossens Thomas Peter Anne

  公开号：US20130090492A1

  公开（公告）日：2013-04-11

  This invention is directed to a general catalyst of high activity and selectivity for the production of a variety of esters, particularly acrylate and methacrylate-based esters, by a transesterification reaction. This objective is achieved by reaction of an ester of a carboxylic or a carbonic acid, in particular of a saturated or unsaturated, typically, a 3 to 4 carbon atom carboxylic acid; with an alcohol in the presence of a catalyst comprising the combination of a metal 1,3-dicarbonyl complex (pref. Zn or Fe acetylacetonate) and a salt, in particular an inorganic salt, pref. ZnCl2, LiCI, NaCI, NH4CI or Lil. These catalysts are prepared from readily available starting materials within the reaction medium without the need for isolation (in-situ preparation).

  这项发明针对一种高活性和选择性的通用催化剂，用于通过酯交换反应生产各种酯类，特别是丙烯酸酯和甲基丙烯酸酯。该目标通过在存在催化剂的情况下，将羧酸酯或碳酸酯的酯，特别是饱和或不饱和的、通常为3到4个碳原子的羧酸酯；与醇反应来实现。催化剂包括金属1,3-二羰基配合物（首选Zn或Fe乙酰丙酮酸盐）和盐的组合，特别是无机盐，首选ZnCl2，LiCl，NaCl，NH4Cl或I2。这些催化剂是在反应介质中从易得的起始物质制备而成，无需分离（原位制备）。
• [EN] WAX COMPOSITIONS COMPRISING LINEAR OLEFIN DIMERS OR HODROGENATED VARIANTS THEREOF AND METHODS FOR PRODUCTION THEREOF<br/>[FR] COMPOSITIONS DE CIRES COMPRENANT DES DIMÈRES D'OLÉFINES LINÉAIRES OU DES VARIANTS HYDROGÉNÉS DE CEUX-CI ET LEUR PROCÉDÉS DE PRODUCTION
  申请人：EXXONMOBIL CHEMICAL PATENTS INC

  公开号：WO2021183327A1

  公开（公告）日：2021-09-16

  Wax compositions may be obtained by providing an olefinic feed comprising a first linear alpha olefin having m carbon atoms and a second linear alpha olefin having n carbon atoms, wherein m and n are independently selected integers each ranging from about 12 to about 100, and the olefinic feed optionally comprises one or more internal olefins and/or one or more branched olefins; contacting the olefinic feed with a metal carbene catalyst in a reactor; forming ethylene and a hydrocarbon substance comprising a linear olefin dimer comprising two carbon atoms less than a sum of m and n; removing the ethylene from the reactor while forming the linear olefin dimer; and isolating a wax composition comprising the linear olefin dimer, a hydrogenated reaction product thereof, or any combination thereof.

  可以通过提供一种含有第一种具有m个碳原子的线性α烯烃和第二种具有n个碳原子的线性α烯烃的烯烃进料来获得蜡组分，其中m和n是独立选择的整数，每个整数范围约为12到100，且烯烃进料可以包括一个或多个内部烯烃和/或一个或多个支链烯烃；在反应器中用金属卡宾催化剂接触烯烃进料；形成乙烯和包含比m和n的和少两个碳原子的线性烯烃二聚体的烃物质；从反应器中除去乙烯，同时形成线性烯烃二聚体；并分离出包含线性烯烃二聚体、其氢化反应产物或任何组合的蜡组分。
• [EN] USE OF BETA-SHEET MIMETICS AS PROTEASE AND KINASE INHIBITORS AND AS INHIBITORS OF TRANSCRIPTION FACTORS<br/>[FR] UTILISATION DE MIMETIQUES DE FEUILLETS BETA COMME INHIBITEURS DE PROTEASE ET DE KINASE OU COMME INHIBITEURS DE FACTEURS DE TRANSCRIPTION
  申请人：MOLECUMETICS LTD.

  公开号：WO1998005333A1

  公开（公告）日：1998-02-12

  (EN) $g(b)-sheet mimetics and methods relating to the same are disclosed. The $g(b)-sheet mimetics have utility as protease and kinase inhibitors, as well as inhibitors of transcription factors. Methods of the invention include administration of a $g(b)-sheet mimetic, or use of the same for the manufacture of a medicament for treatment of a variety of conditions associated with the targeted protease, kinase and/or transcription factor.(FR) L'invention concerne des mimétiques de feuillets bêta et des procédés les concernant. Les mimétiques de feuillets bêta sont utiles comme inhibiteurs de protéase et de kinase ainsi que comme inhibiteurs de facteurs de transcription. Des procédés de l'invention comprennent l'administration d'un mimétique de feuillets bêta ou l'utilisation dudit mimétique pour fabriquer un médicament destiné au traitement d'une variété d'états pathologiques associés à la protéase, à la kinase et/ou au facteur de transcription ciblés.

  （中文翻译）本发明揭示了$g(b)-sheet模拟物及其相关方法。$g(b)-sheet模拟物可用作蛋白酶和激酶抑制剂，以及转录因子的抑制剂。本发明的方法包括给予$g(b)-sheet模拟物，或使用该模拟物制造药物，用于治疗与目标蛋白酶、激酶和/或转录因子相关的各种疾病。
• Beta-sheet mimetics and methods relating to the use thereof
  申请人：Molecumetics Ltd.

  公开号：US20030027819A1

  公开（公告）日：2003-02-06

  &bgr;-sheet mimetics and methods relating to the same are disclosed. The &bgr;-sheet mimetics have utility as protease and kinase inhibitors, as well as inhibitors of transcription factors and protein-protein binding interactions. Methods of the invention include administration of a &bgr;-sheet mimetic, or use of the same for the manufacture of a medicament for treatment of a variety of conditions associated with the targeted protease, kinase, transcription factor and/or protein-protein binding interaction.

  本发明公开了与&bgr;-蛋白质片段模拟物及其相关方法有关的技术。&bgr;-蛋白质片段模拟物可用作蛋白酶和激酶抑制剂，以及转录因子和蛋白质-蛋白质结合相互作用的抑制剂。本发明的方法包括给予&bgr;-蛋白质片段模拟物，或使用该物质制造药物以治疗与目标蛋白酶、激酶、转录因子和/或蛋白质-蛋白质结合相互作用有关的各种疾病条件。