2-[(5-methyl-2-oxindolin-3-ylidene)hydrazono]carbonyl-N-propylbenzamide | 1393098-79-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2-[(5-methyl-2-oxindolin-3-ylidene)hydrazono]carbonyl-N-propylbenzamide
• CAS: 1393098-79-7
• 化学式: C₂₀H₂₀N₄O₃
• 分子量: 364.404
• InChiKey: KYDHNLXSVZIIPZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.22
• 重原子数：
  27.0
• 可旋转键数：
  5.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  99.66
• 氢给体数：
  3.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  氨基邻苯二甲胺 以 乙醇 为溶剂， 反应 24.5h， 生成 2-[(5-methyl-2-oxindolin-3-ylidene)hydrazono]carbonyl-N-propylbenzamide
  参考文献：
  名称：

  Synthesis, characterization andin vitroantimicrobial evaluation of new compounds incorporating oxindole nucleus

  摘要：

  New compounds incorporating with the oxindole nucleus were synthesized via the reaction of substituted isatins [5-methyl-, 5-chloro-and 1-hydroxymethyl isatins] with different nucleophiles. The structures of the newly compounds were elucidated on the basis of FTIR, H-1 NMR, (CMR)-C-13 spectral data, GC/MS and chemical analysis. Investigation of antimicrobial activity of the new compounds was evaluated using broth dilution technique in terms of minimal inhibitory concentration (MIC) count against four pathogenic bacteria and two pathogenic fungi. Most of the new compounds are significantly active against bacteria and fungi. MIC showed that compound (4a) possesses higher effect on Gram-positive bacteria Bacillus cereus than the selected antibacterial agent sulphamethoxazole, whereas compound (11c) possesses more activity against Gram-negative bacteria Shigella dysenterie.

  DOI：

  10.3109/14756366.2011.576251