2-acetylamino-3-pyrazol-1-yl-propionic acid | 38064-98-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-acetylamino-3-pyrazol-1-yl-propionic acid
• 英文别名: 2-Acetamido-3-(1h-pyrazol-1-yl)propanoic acid；2-acetamido-3-pyrazol-1-ylpropanoic acid
• CAS: 38064-98-1
• 化学式: C₈H₁₁N₃O₃
• 分子量: 197.194
• InChiKey: VDJYQDUQGWVWCW-UHFFFAOYSA-N

物化性质

• 沸点：
  495.3±40.0 °C(Predicted)
• 密度：
  1.36±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  84.2
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  吡唑 、 2-乙酰氨基丙烯酸 生成 2-acetylamino-3-pyrazol-1-yl-propionic acid
  参考文献：
  名称：

  Rapid solid phase synthesis of α-amino acids

  摘要：

  A solid phase synthetic method for amino acids is developed. The N-acetyl-dehydroalanine is quantitatively bound to Wang resin by the Mitsunobu method. Then a Michael addition is achieved on the double bond with different nucleophiles. Non proteinic N-acetyl-alpha-amino acids are obtained after cleavage from the resin by mild acid treatment (Scheme 1). (C) 1998 Published by Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(98)01328-8

文献信息

• Rapid solid phase synthesis of α-amino acids
  作者：Mireille Barbaste、Valérie Rolland-Fulcrand、Marie-Louise Roumestant、Philippe Viallefont、Jean Martinez

  DOI：10.1016/s0040-4039(98)01328-8

  日期：1998.8

  A solid phase synthetic method for amino acids is developed. The N-acetyl-dehydroalanine is quantitatively bound to Wang resin by the Mitsunobu method. Then a Michael addition is achieved on the double bond with different nucleophiles. Non proteinic N-acetyl-alpha-amino acids are obtained after cleavage from the resin by mild acid treatment (Scheme 1). (C) 1998 Published by Elsevier Science Ltd. All rights reserved.