5-bromo-1,3-bis[(4S)-4-hydroxy-4-phenyl-2-oxobutyl]-2-methoxybenzene | 497107-20-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-bromo-1,3-bis[(4S)-4-hydroxy-4-phenyl-2-oxobutyl]-2-methoxybenzene
• 英文别名: (1S)-2-[[5-bromo-3-[[(2S)-2-hydroxy-2-phenylethoxy]methyl]-2-methoxyphenyl]methoxy]-1-phenylethanol
• CAS: 497107-20-7
• 化学式: C₂₅H₂₇BrO₅
• 分子量: 487.39
• InChiKey: QNTKSIZGUGHALK-DNQXCXABSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  31
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  68.2
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  5-bromo-1,3-bis[(4S)-4-hydroxy-4-phenyl-2-oxobutyl]-2-methoxybenzene 在 正丁基锂 、 sodium hydride 作用下， 生成 (5S,13S)-21-methoxy-5,13-diphenyl-3,6,9,12,15-pentaoxabicyclo[15.3.1]henicosa-1(20),17(21),18-triene-19-carboxylic acid
  参考文献：
  名称：

  与手性伪-18-冠-6醚共价键合的新型手性固定相的制备和评价

  摘要：

  制备了新的手性固定相，该硅胶由与手性拟18冠6型主体共价结合的硅胶组成，该主体具有OH或OMe基作为结合官能团，用于亲脂性胺的对映体分离。

  DOI：

  10.1016/s0040-4039(03)00020-0
• 作为产物：
  描述：

  5-溴-1,3-二(溴甲基)-2-甲氧基苯 在 4-甲基苯磺酸吡啶 、 sodium hydride 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 反应 21.0h， 生成 5-bromo-1,3-bis[(4S)-4-hydroxy-4-phenyl-2-oxobutyl]-2-methoxybenzene
  参考文献：
  名称：

  Preparation of phenolic chiral crown ethers and podands and their enantiomer recognition ability toward secondary amines

  摘要：

  Phenolic pseudo-24-crown-8 (S,S)-3, pseudo-27-crown-9 (S,S)-4, and podands (R,R)-5 and (R,R)-6 possessing phenyl groups as chiral barriers were prepared and their chiral recognition properties toward secondary neutral amines were examined. Pseudo-24-crown-8 (S,S)-3 and podand (R,R)-5 showed sufficient binding ability and moderate chiral recognition ability toward secondary amines. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(03)00031-4

文献信息

• Chiral recognition of secondary amines by using chiral crown ether and podand
  作者：Keiji Hirose、Akihito Fujiwara、Kazuhisa Matsunaga、Nobuaki Aoki、Yoshito Tobe

  DOI：10.1016/s0040-4039(02)02030-0

  日期：2002.11

  Chiral crown ether (S,S)-3 having a pseudo-24-crown-8 ring and chiral podand (R,R)-4 were prepared and both exhibited good chiral recognition ability toward secondary amines, N-α-dimethylbenzylamine (15) and propranolol (16).

  制备了具有伪24冠8环的手性冠醚（S，S）-3和手性podand（R，R）-4，它们都对仲胺N -α-二甲基苄胺具有良好的手性识别能力（15）和心得安（16）。
• CHIRAL SENSOR
  申请人：Japan Science and Technology Agency

  公开号：EP1538148B1

  公开（公告）日：2007-01-10
• Molecular-wire type fluorescent chiral sensor
  申请人：Tobe Yoshito

  公开号：US20070179272A1

  公开（公告）日：2007-08-02

  A fluorescent molecular wire is provided, having a fluorescent polymer main chain to which an optically active substituent is linked so as to be conjugatable form, the optically active substituent being represented by formula (I) below: where R 1 represents a hydrogen atom or an alkyl group having 1 to 10 carbon atoms; R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , and R 9 represent independently a hydrogen atom, a linear alkyl group having 1 to 30 carbon atoms that may have a substituent, a branched alkyl group having 2 to 30 carbon atoms that may have a substituent, a cyclic alkyl group having 3 to 30 carbon atoms that may have a substituent, an aryl group having 6 to 30 carbon atoms that may have a substituent, or an aralkyl group having 7 to 30 carbon atoms that may have a substituent, and R 3 and R 7 may be bonded respectively to R 4 and R 8 to form an alkylene group having 2 to 60 carbon atoms that may have a substituent; and R 10 and R 11 represent independently a hydrogen atom or an alkyl group having 1 to 15 carbon atoms that may have a heteroatom, and R 10 and R 11 may be bonded to form an alkylene group having 2 to 30 carbon atoms that may have a heteroatom.
• US7358403B2
  申请人：——

  公开号：US7358403B2

  公开（公告）日：2008-04-15
• US7781223B2
  申请人：——

  公开号：US7781223B2

  公开（公告）日：2010-08-24