N-[(2-chlorophenyl)methylideneamino]-4-hydroxybenzamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[(2-chlorophenyl)methylideneamino]-4-hydroxybenzamide
• 化学式: C₁₄H₁₁ClN₂O₂
• 分子量: 274.707
• InChiKey: RTFXGOLWDKMXKC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  61.7
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-[(2-chlorophenyl)methylideneamino]-4-hydroxybenzamide 、 乙酸酐 反应 2.0h， 生成
  参考文献：
  名称：

  Oxadiazole based Os(IV) compounds as potential DNA intercalator and cytotoxic agents

  摘要：

  Os(IV) compounds and ligands have been synthesized and well characterized. DNA cleavage tendency of compounds has been evaluated using gel electrophoresis and binding behavior has been evaluated by viscosity measurements, absorption titration, fluorescence, and docking studies. All the compounds show the intercalation mode of binding. The binding constant of complexes falls at about 1.8-7.6 x 10(4) M-1 Bacteriostatic activity of compounds has been evaluated on a series of gram(+ve )and gram(-ve) bacteria in terms of their MIC values. Also, the compounds have been screened for in vivo and in vitro cytotoxicity assays on S. Pombe cell's DNA and HCT-116 cell line. LC50 of ligands and Os(IV) complexes are in the range of 7.92-19.91 and 4.00-11.74 mu g/mL respectively.

  DOI：

  10.1016/j.inoche.2020.108070
• 作为产物：
  描述：

  对羟基苯甲酸甲酯 在 一水合肼 、 溶剂黄146 作用下， 以 乙醇 为溶剂， 反应 6.0h， 生成 N-[(2-chlorophenyl)methylideneamino]-4-hydroxybenzamide
  参考文献：
  名称：

  对结核分枝杆菌 H37Rv 具有抗结核活性的新型苯甲酰肼衍生物的合成、药代动力学和分子对接研究

  摘要：

  结核病祸害是最值得注意的危险，迫切需要确定新的防御措施。一系列新的苯甲酰肼衍生物，含有亚苄基苯甲酰肼与 2-溴-1-(4-氟苯基)乙酮通过亚甲氧基连接。苯甲酰肼衍生物的表征通过1 H 和13 C NMR、FT-IR 和质谱法进行。对合成的化合物进行抗微生物活性筛选，并在计算机筛选中进行评估。所有合成的化合物对体外抗结核分枝杆菌H37Rv 和 4 小时的抗结核活性测量显示超过 99% 的生长抑制。

  DOI：

  10.1016/j.molstruc.2021.131884

文献信息

• Oxadiazole based Os(IV) compounds as potential DNA intercalator and cytotoxic agents
  作者：Bharat H. Pursuwani、Bhupesh S. Bhatt、Foram U. Vaidya、Chandramani Pathak、Mohan N. Patel

  DOI：10.1016/j.inoche.2020.108070

  日期：2020.9

  Os(IV) compounds and ligands have been synthesized and well characterized. DNA cleavage tendency of compounds has been evaluated using gel electrophoresis and binding behavior has been evaluated by viscosity measurements, absorption titration, fluorescence, and docking studies. All the compounds show the intercalation mode of binding. The binding constant of complexes falls at about 1.8-7.6 x 10(4) M-1 Bacteriostatic activity of compounds has been evaluated on a series of gram(+ve )and gram(-ve) bacteria in terms of their MIC values. Also, the compounds have been screened for in vivo and in vitro cytotoxicity assays on S. Pombe cell's DNA and HCT-116 cell line. LC50 of ligands and Os(IV) complexes are in the range of 7.92-19.91 and 4.00-11.74 mu g/mL respectively.
• Synthesis, pharmacokinetic and molecular docking studies of new benzohydrazide derivatives possessing anti-tubercular activity against Mycobacterium tuberculosis H37Rv
  作者：Nilam H. Lalavani、Himani R. Gandhi、Krishna A. Bhensdadia、Rajesh K. Patel、Shipra H. Baluja

  DOI：10.1016/j.molstruc.2021.131884

  日期：2022.2

  defenses against it. A new series of benzohydrazide derivatives containing benzylidene benzohydrazide linkage with 2-bromo-1-(4-fluorophenyl)ethanone via methylene-oxy group. The characterization of benzohydrazide derivatives was performed by 1H and 13C NMR, FT-IR and mass spectrometry. The synthesized compounds were screened for antimicrobial activity and evaluated for in silico screening. All the synthesized

  结核病祸害是最值得注意的危险，迫切需要确定新的防御措施。一系列新的苯甲酰肼衍生物，含有亚苄基苯甲酰肼与 2-溴-1-(4-氟苯基)乙酮通过亚甲氧基连接。苯甲酰肼衍生物的表征通过1 H 和13 C NMR、FT-IR 和质谱法进行。对合成的化合物进行抗微生物活性筛选，并在计算机筛选中进行评估。所有合成的化合物对体外抗结核分枝杆菌H37Rv 和 4 小时的抗结核活性测量显示超过 99% 的生长抑制。