2-(3-Acetylaminophenyl)phenol | 1261896-19-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(3-Acetylaminophenyl)phenol
• 英文别名: N-[3-(2-hydroxyphenyl)phenyl]acetamide
• CAS: 1261896-19-8
• 化学式: C₁₄H₁₃NO₂
• 分子量: 227.263
• InChiKey: BQPRQHLISSXNIT-UHFFFAOYSA-N

物化性质

• 沸点：
  461.2±28.0 °C(Predicted)
• 密度：
  1.220±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(3-Acetylaminophenyl)phenol 在 copper diacetate 、 caesium carbonate 、 三甲基乙酸 作用下， 以 二甲基亚砜 为溶剂， 反应 24.0h， 以69%的产率得到4-acetamidodibenzofuran
  参考文献：
  名称：

  Copper-Catalyzed Regioselective C-H Aerobic Oxidative Cycloetherification of o-Arylphenols Bearing an Additional Directing Group

  摘要：

  An efficient copper-catalyzed C-H oxidative cycloetherification of o-arylphenols containing an additional directing group under an oxygen atmosphere was developed. 2,6-Disubstituted dibenzofuran derivatives were prepared by regioselective activation of the sterically more hindered C-H bond. The presence of the extra directing group not only controls the regioselectivity, but also increases the cyclization efficiency significantly.

  DOI：

  10.1055/s-0031-1290966
• 作为产物：
  描述：

  2-碘苯酚 、 3-乙酰胺基苯硼酸 在 bis-triphenylphosphine-palladium(II) chloride 、 potassium carbonate 作用下， 以 1,4-二氧六环 、 水 为溶剂， 以58%的产率得到2-(3-Acetylaminophenyl)phenol
  参考文献：
  名称：

  Copper-Catalyzed Regioselective C-H Aerobic Oxidative Cycloetherification of o-Arylphenols Bearing an Additional Directing Group

  摘要：

  An efficient copper-catalyzed C-H oxidative cycloetherification of o-arylphenols containing an additional directing group under an oxygen atmosphere was developed. 2,6-Disubstituted dibenzofuran derivatives were prepared by regioselective activation of the sterically more hindered C-H bond. The presence of the extra directing group not only controls the regioselectivity, but also increases the cyclization efficiency significantly.

  DOI：

  10.1055/s-0031-1290966

文献信息

• Copper-Catalyzed Regioselective C-H Aerobic Oxidative Cycloetherification of o-Arylphenols Bearing an Additional Directing Group
  作者：Qiang Zhu、Jiaji Zhao、Yong Wang

  DOI：10.1055/s-0031-1290966

  日期：2012.5

  An efficient copper-catalyzed C-H oxidative cycloetherification of o-arylphenols containing an additional directing group under an oxygen atmosphere was developed. 2,6-Disubstituted dibenzofuran derivatives were prepared by regioselective activation of the sterically more hindered C-H bond. The presence of the extra directing group not only controls the regioselectivity, but also increases the cyclization efficiency significantly.