DY163 | 212575-51-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: DY163
• 英文别名: 4-Hydroxy-benzoic acid (4-methyl-benzylidene)-hydrazide；4-hydroxy-N-[(4-methylphenyl)methylideneamino]benzamide
• CAS: 212575-51-4
• 化学式: C₁₅H₁₄N₂O₂
• 分子量: 254.288
• InChiKey: CFSQHJXRIUXOIN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  61.7
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 海关编码：
  2928000090

反应信息

• 作为反应物：
  描述：

  DY163 、 乙酸酐 反应 2.0h， 生成
  参考文献：
  名称：

  Oxadiazole based Os(IV) compounds as potential DNA intercalator and cytotoxic agents

  摘要：

  Os(IV) compounds and ligands have been synthesized and well characterized. DNA cleavage tendency of compounds has been evaluated using gel electrophoresis and binding behavior has been evaluated by viscosity measurements, absorption titration, fluorescence, and docking studies. All the compounds show the intercalation mode of binding. The binding constant of complexes falls at about 1.8-7.6 x 10(4) M-1 Bacteriostatic activity of compounds has been evaluated on a series of gram(+ve )and gram(-ve) bacteria in terms of their MIC values. Also, the compounds have been screened for in vivo and in vitro cytotoxicity assays on S. Pombe cell's DNA and HCT-116 cell line. LC50 of ligands and Os(IV) complexes are in the range of 7.92-19.91 and 4.00-11.74 mu g/mL respectively.

  DOI：

  10.1016/j.inoche.2020.108070
• 作为产物：
  描述：

  对羟基苯甲酸甲酯 在 一水合肼 作用下， 以 乙醇 为溶剂， 反应 19.0h， 生成 DY163
  参考文献：
  名称：

  一些新型对羟基苯甲酰肼衍生物的合成、抗高血压活性和 3D-QSAR 研究

  摘要：

  p-羟基苯甲酰肼 2 用芳香族/脂肪族醛处理，然后用二硫化碳环化得到化合物 4a-4n。同样，化合物2通过处理取代的异硫氰酸酯然后处理氯乙酸产生相应的化合物6a-6i。通过无创血压测量和有创血压测量方法测定所有测试化合物的抗高血压活性。测试化合物显示出显着的抗高血压活性。完整的化合物进行了 3D-QSAR 研究。通过PHASE程序进行3D-QSAR分析，获得了具有良好预测能力（r2 = 0.98，q2 = 0.74）的统计可靠模型。

  DOI：

  10.1002/ardp.201000008

文献信息

• Ligands for estrogen related receptors and methods for synthesis of said ligands
  申请人：Forman Barry

  公开号：US20060189825A1

  公开（公告）日：2006-08-24

  Estrogen-Related Receptor (ERR) modulating compounds and methods for synthesis of said compounds are described.

  本文描述了调节雌激素相关受体（ERR）的化合物以及合成该化合物的方法。
• LIGANDS FOR ESTROGEN RELATED RECEPTORS AND METHODS FOR SYNTHESIS OF SAID LIGANDS
  申请人：Forman Barry

  公开号：US20090318693A1

  公开（公告）日：2009-12-24

  Estrogen-Related Receptor (ERR) modulating compounds and methods for synthesis of said compounds are described.

  本文描述了调节雌激素相关受体（ERR）的化合物以及制备该化合物的方法。
• Synthesis, Antihypertensive Activity, and 3D-QSAR Studies of Some New p-Hydroxybenzohydrazide Derivatives
  作者：Ritesh P. Bhole、Kishore P. Bhusari

  DOI：10.1002/ardp.201000008

  日期：2011.2

  p‐Hydroxybenzohydrazide 2 on treatment with aromatic/aliphatic aldehyde followed by cyclization with carbon disulphide afforded compounds 4a–4n. Also, compound 2 by treatment of substituted isothiocyanate followed by the treatment of chloroacetic acid yields the corresponding compounds 6a–6i. All the test compounds were assayed for antihypertensive activity by non‐invasive blood pressure measurement

  p-羟基苯甲酰肼 2 用芳香族/脂肪族醛处理，然后用二硫化碳环化得到化合物 4a-4n。同样，化合物2通过处理取代的异硫氰酸酯然后处理氯乙酸产生相应的化合物6a-6i。通过无创血压测量和有创血压测量方法测定所有测试化合物的抗高血压活性。测试化合物显示出显着的抗高血压活性。完整的化合物进行了 3D-QSAR 研究。通过PHASE程序进行3D-QSAR分析，获得了具有良好预测能力（r2 = 0.98，q2 = 0.74）的统计可靠模型。
• Oxadiazole based Os(IV) compounds as potential DNA intercalator and cytotoxic agents
  作者：Bharat H. Pursuwani、Bhupesh S. Bhatt、Foram U. Vaidya、Chandramani Pathak、Mohan N. Patel

  DOI：10.1016/j.inoche.2020.108070

  日期：2020.9

  Os(IV) compounds and ligands have been synthesized and well characterized. DNA cleavage tendency of compounds has been evaluated using gel electrophoresis and binding behavior has been evaluated by viscosity measurements, absorption titration, fluorescence, and docking studies. All the compounds show the intercalation mode of binding. The binding constant of complexes falls at about 1.8-7.6 x 10(4) M-1 Bacteriostatic activity of compounds has been evaluated on a series of gram(+ve )and gram(-ve) bacteria in terms of their MIC values. Also, the compounds have been screened for in vivo and in vitro cytotoxicity assays on S. Pombe cell's DNA and HCT-116 cell line. LC50 of ligands and Os(IV) complexes are in the range of 7.92-19.91 and 4.00-11.74 mu g/mL respectively.