benzyl (2S)-2-(carbonochloridoylamino)-3-tri(propan-2-yl)silyloxypropanoate | 203736-16-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: benzyl (2S)-2-(carbonochloridoylamino)-3-tri(propan-2-yl)silyloxypropanoate
• CAS: 203736-16-7
• 化学式: C₂₀H₃₂ClNO₄Si
• 分子量: 414.017
• InChiKey: YXTFWQQZHWXETA-SFHVURJKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.24
• 重原子数：
  27
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  64.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  benzyl (2S)-2-(carbonochloridoylamino)-3-tri(propan-2-yl)silyloxypropanoate 在 palladium on activated charcoal 氢气 、 三乙胺 作用下， 以 乙醇 、 二氯甲烷 为溶剂， 反应 25.5h， 生成 (S)-2-[3-((S)-2-tert-Butoxycarbonylamino-2-methoxycarbonyl-ethyl)-1H-indol-5-yloxycarbonylamino]-3-triisopropylsilanyloxy-propionic acid
  参考文献：
  名称：

  Novel serine-based linker for the solid-phase synthesis of organic compounds

  摘要：

  A novel serine-derived Linker has been developed that allows phenolic templates to be cleaved from the resin with fluoride ion. The linker is stable to acids such as TFA and bases such as pyrrolidine. The linker should provide utility in multi-step solid phase organic chemistry protocols where both acid and base chemistry is used. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(97)10618-9
• 作为产物：
  描述：

  丝氨酸苄酯盐酸盐 在 吡啶 、 三乙胺 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 反应 24.5h， 生成 benzyl (2S)-2-(carbonochloridoylamino)-3-tri(propan-2-yl)silyloxypropanoate
  参考文献：
  名称：

  Novel serine-based linker for the solid-phase synthesis of organic compounds

  摘要：

  A novel serine-derived Linker has been developed that allows phenolic templates to be cleaved from the resin with fluoride ion. The linker is stable to acids such as TFA and bases such as pyrrolidine. The linker should provide utility in multi-step solid phase organic chemistry protocols where both acid and base chemistry is used. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(97)10618-9

文献信息

• Novel serine-based linker for the solid-phase synthesis of organic compounds
  作者：Yuo-Ling Chou、Michael M. Morrissey、Raju Mohan

  DOI：10.1016/s0040-4039(97)10618-9

  日期：1998.2

  A novel serine-derived Linker has been developed that allows phenolic templates to be cleaved from the resin with fluoride ion. The linker is stable to acids such as TFA and bases such as pyrrolidine. The linker should provide utility in multi-step solid phase organic chemistry protocols where both acid and base chemistry is used. (C) 1998 Elsevier Science Ltd. All rights reserved.