十六碳烯酸甲酯 | 41240-59-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 十六碳烯酸甲酯
• 英文名称: methyl hexadec-15-enoate
• 英文别名: Hexadec-15-en-1-saeure-methylester；Methyl 15-hexadecenoate
• CAS: 41240-59-9
• 化学式: C₁₇H₃₂O₂
• 分子量: 268.44
• InChiKey: HNDVDUYXVMYIQN-UHFFFAOYSA-N

物化性质

• 沸点：
  165 °C(Press: 0.5 Torr)
• 密度：
  0.872±0.06 g/cm3(Predicted)
• 稳定性/保质期：
  存在于烤烟和香料烟的烟叶中。

计算性质

• 辛醇/水分配系数(LogP)：
  6.9
• 重原子数：
  19
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

制备方法与用途

制备方法

• 烟草: OR,26；FC,40。

合成制备方法

• 烟草: OR，26；FC，40。

用途简介

暂无相关说明。

反应信息

• 作为反应物：
  描述：

  十六碳烯酸甲酯 在 盐酸 、 二叔丁基过氧化物 作用下， 生成 dimethyl 2-methyloctadecane-1,18-dioate
  参考文献：
  名称：

  Comeau,D. et al., Bulletin de la Societe Chimique de France, 1972, p. 4163 - 4170

  摘要：

  DOI：
• 作为产物：
  描述：

  6-oxo-Δ¹⁵-hexadecanoic acid 生成 十六碳烯酸甲酯
  参考文献：
  名称：

  含γ-羧酸盐的双氨基乙硫醇（蝙蝠）螯合剂的新合成

  摘要：

  描述了含有长链脂肪酸部分的双（氨基乙硫醇）的新合成。由于避免了使用强还原剂（如氢化铝锂），因此所描述的方法相对于文献方法具有优势。

  DOI：

  10.1016/s0040-4039(00)99324-9

文献信息

• Selective Long-Distance Isomerization of Terminal Alkenes via Nondissociative Chain Walking
  作者：Yuya Yamasaki、Takaaki Kumagai、Shota Kanno、Fumitoshi Kakiuchi、Takuya Kochi

  DOI：10.1021/acs.joc.8b01288

  日期：2018.8.17

  Selective long-distance isomerization of terminal alkenes to silyl enol ethers proceeded via nondissociative chain walking using phenanthroline palladium catalysts. Notable features achieved taking advantage of the nondissociative chain walking mechanism include high efficiency obtained regardless of the chain length, high chemoselectivity toward terminal alkenes over internal ones, and retention of

  末端烯烃向甲硅烷基烯醇醚的选择性长距离异构化是通过使用菲咯啉钯催化剂的非解离链走进行的。利用非解离链行走机制获得的显着特征包括无论链长如何都获得了高效率，相对于内部烯烃对末端烯烃的高化学选择性以及在烷基链上保留了立体中心的立体构型。
• Macrocyclic musk compounds—IV
  作者：M.S.R. Nair、H.H. Mathur、S.C. Bhattacharyya

  DOI：10.1016/s0040-4020(01)99345-7

  日期：1963.1

  enamines followed by ring cleavage yielded keto-enoic acids. The latter on Huang-Minlon reduction gave the enoic acids which on oxidation furnished the dioic acids. Ozonization of the enoic acids followed by sodium borohydride reduction of the ozonide yielded ω-hydroxy acids. The C16 and C15 dioic and ω-hydroxy acids, suitable for conversion to macrocyclic ketones and lactones, were thus prepared.

  与烯胺缩合的十一碳十烯酰氯，然后进行环裂解，得到酮-烯酸。后者在黄敏隆还原反应中得到烯酸，而烯酸在氧化时提供了二酸。烯酸的臭氧化，然后将硼氢化钠还原为臭氧化物，得到ω-羟基酸。由此制备了适于转化为大环酮和内酯的C 16和C 15二元酸和ω-羟基酸。
• Diluted microemulsions with low surface tensions
  申请人：Flotek Chemistry, LLC

  公开号：US11180690B2

  公开（公告）日：2021-11-23

  Compositions relating to microemulsions or diluted microemulsions for treating gas wells having wellbores and methods related to treating gas wells having wellbores using the same are generally provided. In some embodiments, the microemulsions or diluted microemulsions have an especially low surface tension at a gas well bottom hole temperature and pressure.

  一般提供了用于处理具有井筒的气井的微乳液或稀释微乳液的相关组合物，以及使用这些组合物处理具有井筒的气井的相关方法。在某些实施方案中，微乳液或稀释微乳液在气井井底温度和压力下具有特别低的表面张力。
• DILUTED MICROEMULSIONS WITH LOW SURFACE TENSIONS
  申请人：Flotek Chemistry, LLC

  公开号：US20190284467A1

  公开（公告）日：2019-09-19

  Compositions relating to microemulsions or diluted microemulsions for treating gas wells having wellbores and methods related to treating gas wells having wellbores using the same are generally provided. In some embodiments, the microemulsions or diluted microemulsions have an especially low surface tension at a gas well bottom hole temperature and pressure.
• [EN] ATOVAQUONE PRODRUGS<br/>[FR] PROMÉDICAMENTS D'ATOVAQUONE
  申请人：[en]IPCA LABORATORIES LIMITED

  公开号：WO2022144920A1

  公开（公告）日：2022-07-07

  The present invention discloses Atovaquone prodrugs, process for the preparation of said prodrugs and pharmaceutical compositions comprising Atovaquone prodrugs. Atovaquone prodrugs of the present invention can be used alone, or co-administered orally or parenterally as fixed dose or as separate dosage form in combinations with other anti-parasitic drugs for both prophylaxis and treatment of ecto and endo-parasitic infections in humans. The pharmaceutical compositions offer high drug loading due to higher solubility compared to Atovaquone and provides sustained depot effect, thus providing therapeutically effective concentration of active drug for longer duration.