3-Benzoyl-1-[4-[tert-butyl(dimethyl)silyl]oxybutan-2-yl]-5-methylpyrimidine-2,4-dione | 378750-56-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-Benzoyl-1-[4-[tert-butyl(dimethyl)silyl]oxybutan-2-yl]-5-methylpyrimidine-2,4-dione
• 英文别名: 3-benzoyl-1-[4-[tert-butyl(dimethyl)silyl]oxybutan-2-yl]-5-methylpyrimidine-2,4-dione
• CAS: 378750-56-2
• 化学式: C₂₂H₃₂N₂O₄Si
• 分子量: 416.593
• InChiKey: DXHXMSSNIXAFEO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.98
• 重原子数：
  29
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  66.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-Benzoyl-1-[4-[tert-butyl(dimethyl)silyl]oxybutan-2-yl]-5-methylpyrimidine-2,4-dione 在 对甲苯磺酸 作用下， 以 四氢呋喃 、 水 为溶剂， 生成
  参考文献：
  名称：

  Stereoselective construction of the azabicyclic core applicable to the biologically important polyguanidinium alkaloids batzelladine A and D using a free radical cyclization

  摘要：

  The intramolecular addition of the free radical derived from the alkyl bromide 13 provides an expeditious and stereoselective approach to the azabicyclic core 14, which is applicable to the biologically important polyguanidinium alkaloids batzelladine A (1) and D (2). (C) 2001 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(01)01340-5
• 作为产物：
  描述：

  4-((tert-butyldimethylsilyl)oxy)butan-2-ol 、 N-3-benzoylthymine 在 三苯基膦 、 偶氮二甲酸二乙酯 作用下， 以 四氢呋喃 为溶剂， 以72%的产率得到3-Benzoyl-1-[4-[tert-butyl(dimethyl)silyl]oxybutan-2-yl]-5-methylpyrimidine-2,4-dione
  参考文献：
  名称：

  Stereoselective construction of the azabicyclic core applicable to the biologically important polyguanidinium alkaloids batzelladine A and D using a free radical cyclization

  摘要：

  The intramolecular addition of the free radical derived from the alkyl bromide 13 provides an expeditious and stereoselective approach to the azabicyclic core 14, which is applicable to the biologically important polyguanidinium alkaloids batzelladine A (1) and D (2). (C) 2001 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(01)01340-5

文献信息

• Stereoselective construction of the azabicyclic core applicable to the biologically important polyguanidinium alkaloids batzelladine A and D using a free radical cyclization
  作者：P.Andrew Evans、Thara Manangan

  DOI：10.1016/s0040-4039(01)01340-5

  日期：2001.9

  The intramolecular addition of the free radical derived from the alkyl bromide 13 provides an expeditious and stereoselective approach to the azabicyclic core 14, which is applicable to the biologically important polyguanidinium alkaloids batzelladine A (1) and D (2). (C) 2001 Published by Elsevier Science Ltd.