N-phenyl-2-((propan-2-ylideneamino)oxy)acetamide | 94427-92-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-phenyl-2-((propan-2-ylideneamino)oxy)acetamide
• 英文别名: O-Isopropylidenamino-glykolsaeureanilid；N-phenyl-2-(propan-2-ylideneamino)oxyacetamide
• CAS: 94427-92-6
• 化学式: C₁₁H₁₄N₂O₂
• mdl: MFCD24392236
• 分子量: 206.244
• InChiKey: SAGQRDNGGFVOPA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.272
• 拓扑面积：
  50.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  丙酮羧甲基肟 在 氯化亚砜 作用下， 生成 N-phenyl-2-((propan-2-ylideneamino)oxy)acetamide
  参考文献：
  名称：

  �ber einige Derivate der Aminoxyessigs�ure

  摘要：

  DOI：

  10.1007/bf00918631

文献信息

• Ligand-Enabled C–H Olefination and Lactonization of Benzoic Acids and Phenylacetic Acids via Palladium Catalyst
  作者：Yangyang Wang、Xiaobo Xu、Gaorong Wu、Binghan Pang、Shaowen Liao、Yafei Ji

  DOI：10.1021/acs.orglett.1c04000

  日期：2022.1.28

  A novel ligand propan-2-one O-(p-tolylcarbamoyl) oxime (L7) has been developed to promote C(sp2)–H olefination of benzoic acids and phenylacetic acids via a palladium catalyst. With the subsequent lactonization of the olefinated products through 1,4-addition, highly monoselective cyclic lactone products of benzofuranones and benzopyrones were obtained in moderate to excellent yields. The DFT calculation

  已开发出一种新型配体 propan-2-one O -( p -tolylcarbamoyl) oxime ( L7 ) 以通过钯催化剂促进苯甲酸和苯乙酸的C(sp 2 )-H 烯化。随后通过1,4-加成对烯烃产物进行内酯化，以中等至优异的产率获得苯并呋喃酮和苯并吡喃酮的高单选择性环状内酯产物。DFT计算表明，新型配体propan-2-one O -( p -tolylcarbamoyl) oxime ( L7 ) 可以改善C-H活化反应，优雅地生成环状内酯产物。
• Inhibitors of 15-hydroxyprostaglandin dehydrogenase for stimulating pigmentation of the skin or skin appendages
  申请人：Michelet Jean-Francois

  公开号：US20060034786A1

  公开（公告）日：2006-02-16

  Inhibitors of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), for example tetrazole, styrylpyrazole, phenylfuran, phenylthiophene, phenylpyrrazole, pyrazolecarboxamide, 2-thioacetamide and azo compounds, are useful for promoting or stimulating pigmentation of the skin and/or skin appendages and/or for preventing and/or for limiting depigmentation and/or whitening of the skin and/or skin appendages, notably for preventing and/or limiting canities.

  15-羟基前列腺素脱氢酶（15-PGDH）的抑制剂，例如四唑、苯基吡唑、苯基呋喃、苯基噻吩、苯基吡唑、吡唑羧酰胺、2-硫代乙酰胺和偶氮化合物，可用于促进或刺激皮肤和/或皮肤附属物的色素沉淀和/或预防和/或限制皮肤和/或皮肤附属物的脱色和/或变白，特别是用于预防和/或限制白发。
• Care/makeup compositions comprising a 2-alkylideneaminooxyacetamide compound for stimulating the growth of the hair or eyelashes and/or slowing loss thereof
  申请人：Rozot Roger

  公开号：US20060026775A1

  公开（公告）日：2006-02-09

  A regime/regimen (and compositions therefor) for inducing and/or stimulating the growth of keratinous fibers and/or slowing the loss and/or increasing the density thereof, notably human hair and/or eyelashes, entails administering to a mammalian subject in need of such treatment, for such period of time as required to elicit the desired effect, a thus effective amount of at least one 2-alkylideneaminooxyacetamide compound having the formula (1):

  一种用于诱导和/或刺激角质纤维生长和/或减缓其流失和/或增加密度的方案/方案组合（以及其组成物），尤其是人类头发和/或睫毛的生长，涉及向需要此类治疗的哺乳动物主体施用至少一种具有公式（1）的有效量的2-烷基亚胺氧乙酸酰胺化合物，持续时间如所需以引发所需的效果。
• INHIBITORS OF 15-HYDROXYPROSTAGLANDIN DEHYDROGENASE FOR STIMULATING PIGMENTATION OF THE SKIN OR SKIN APPENDAGES
  申请人：MICHELET JEAN-FRANCOIS

  公开号：US20110014250A1

  公开（公告）日：2011-01-20

  Inhibitors of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), for example tetrazole, styrylpyrazole, phenylfuran, phenylthiophene, phenylpyrrazole, pyrazolecarboxamide, 2-thioacetamide and azo compounds, are useful for promoting or stimulating pigmentation of the skin and/or skin appendages and/or for preventing and/or for limiting depigmentation and/or whitening of the skin and/or skin appendages, notably for preventing and/or limiting canities.

  15-羟基前列腺素脱氢酶（15-PGDH）的抑制剂，例如四唑、苯乙烯吡唑、苯并呋喃、苯并硫吩、苯并吡唑、吡唑羧酰胺、2-硫代乙酰胺和偶氮化合物，可用于促进或刺激皮肤和/或皮肤附属物的色素沉着，或预防和/或限制皮肤和/或皮肤附属物的脱色和/或变白，特别是预防和/或限制白发。
• CARE OR MAKE-UP COMPOSITION COMPRISING A 2-ALKYLIDENEAMINOOXYACETAMIDE, ITS USE FOR STIMULATING THE GROWTH OF THE HAIR OR EYELASHES AND/OR SLOWING DOWN THEIR LOSS
  申请人：L'OREAL

  公开号：EP1587486A2

  公开（公告）日：2005-10-26