2-butoxy-N,N-dimethylbenzeneamine | 1151860-41-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-butoxy-N,N-dimethylbenzeneamine
• 英文别名: 2-butoxy-N,N-dimethylaniline
• CAS: 1151860-41-1
• 化学式: C₁₂H₁₉NO
• 分子量: 193.289
• InChiKey: GKMMNAORXVRRCY-UHFFFAOYSA-N

物化性质

• 沸点：
  249.4±13.0 °C(predicted)
• 密度：
  0.961±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-butoxy-N,N-dimethylbenzeneamine 、 三氟甲烷磺酸甲酯 以 二氯甲烷 为溶剂， 以100%的产率得到2-butoxy-N,N,N-trimethylbenzenaminium trifluoromethanesulfonate
  参考文献：
  名称：

  A process for the rapid removal of dialkylamino-substituents from aromatic rings. Application to the expedient synthesis of (R)-tolterodine

  摘要：

  A range of N,N-dialkylanilines have been Successfully converted to the parent Substituted benzenes by a novel two-step pathway. The products are obtained in good yields and optical purity of adjacent stereocenters is maintained. This technology has been applied toward the synthesis of (R)-tolterodine. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.12.054

文献信息

• A process for the rapid removal of dialkylamino-substituents from aromatic rings. Application to the expedient synthesis of (R)-tolterodine
  作者：Nick A. Paras、Bryon Simmons、David W.C. MacMillan

  DOI：10.1016/j.tet.2008.12.054

  日期：2009.4

  A range of N,N-dialkylanilines have been Successfully converted to the parent Substituted benzenes by a novel two-step pathway. The products are obtained in good yields and optical purity of adjacent stereocenters is maintained. This technology has been applied toward the synthesis of (R)-tolterodine. (C) 2009 Elsevier Ltd. All rights reserved.