[7-(3-Aminophenyl)-5-methyl-pyrazolo[1,5-a]pyrimidin-3-yl]-2-thienyl-methanone | 879373-60-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: [7-(3-Aminophenyl)-5-methyl-pyrazolo[1,5-a]pyrimidin-3-yl]-2-thienyl-methanone
• 英文别名: [7-(3-aminophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-3-yl]-thiophen-2-ylmethanone
• CAS: 879373-60-1
• 化学式: C₁₈H₁₄N₄OS
• 分子量: 334.401
• InChiKey: ISVRLAGYXDLTJU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  102
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  [7-(3-Aminophenyl)-5-methyl-pyrazolo[1,5-a]pyrimidin-3-yl]-2-thienyl-methanone 、 环氧丙酸 生成 N-{3-[3-(2-thienylcarbonyl)pyrazolo[1,5-a]pyrimidin-7-yl]phenyl}-2-oxiranecarboxamide
  参考文献：
  名称：

  Method of using substituted pyrazolo [1,5-a] pyrimidines

  摘要：

  本发明涉及使用某些吡唑并[1,5-a]嘧啶化合物及其治疗上可接受的盐的新方法。本发明还涉及使用这些化合物作为哺乳动物，包括人类的抗增殖剂的新方法。

  公开号：

  US20060063784A1
• 作为产物：
  描述：

  (3-氨基吡唑-4-基)(2-噻吩)甲酮 在 铁粉 、 氯化铵 、 溶剂黄146 作用下， 以 甲醇 、 水 为溶剂， 生成 [7-(3-Aminophenyl)-5-methyl-pyrazolo[1,5-a]pyrimidin-3-yl]-2-thienyl-methanone
  参考文献：
  名称：

  Pyrazolo[1,5-a]pyrimidin-7-yl phenyl amides as novel antiproliferative agents: Exploration of core and headpiece structure–activity relationships

  摘要：

  A novel series of antiproliferative agents containing pyrazolo[1,5-a]pyrimidin-7-yl phenyl amides, selective for p21-deficient cells, were identified by high-throughput screening. Exploration of the SAR relationships in the headpiece, core, and tailpiece is described. Strict steric, positional, and electronic requirements were observed, with a clear preference for both core nitrogens, a thienoyl headpiece, and meta substituted tailpiece. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.12.116

文献信息

• Substituted pyrazolo[1,5-a] pyrimidines and process for making same
  申请人：Wang Daniel Yanong

  公开号：US20060063785A1

  公开（公告）日：2006-03-23

  This invention relates to novel pyrazolo[1,5-a]pyrimidine compounds and the therapeutically acceptable salts thereof. These compounds are useful as anti-proliferative agents in mammals, including humans.

  这项发明涉及新型吡唑并[1,5-a]嘧啶化合物及其治疗上可接受的盐。这些化合物在哺乳动物，包括人类中作为抗增殖剂是有用的。
• [EN] METHOD OF USING SUBSTITUTED PYRAZOLO [1,5-a] PYRIMIDINES<br/>[FR] METHODE D'UTILISATION DE PYRAZOLO [1,5-A] PYRIMIDINES SUBSTITUEES
  申请人：WYETH CORP

  公开号：WO2006033795A2

  公开（公告）日：2006-03-30

  This invention relates to novel methods of use of certain pyrazolo[1,5-a]pyrimidine compounds and the therapeutically acceptable salts thereof. This invention also relates to novel methods of using these compounds as antiproliferative agents in mammals, including humans.
• [EN] SUBSTITUTED PYRAZOLO [1,5-a] PYRIMIDINES AND PROCESS FOR MAKING SAME<br/>[FR] PYRAZOLO [1,5-A] PYRIMIDINES SUBSTITUEES ET LEUR PROCEDE DE FABRICATION
  申请人：WYETH CORP

  公开号：WO2006033796A1

  公开（公告）日：2006-03-30

  This invention relates to novel pyrazolo[1,5-a]pyrimidine compounds and the therapeutically acceptable salts thereof. These compounds are useful as anti­proliferative agents in mammals, including humans.