methyl 2-methoxybenzylcarbamate | 143558-79-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: methyl 2-methoxybenzylcarbamate
• 英文别名: Methyl [(2-methoxyphenyl)methyl]carbamate；methyl N-[(2-methoxyphenyl)methyl]carbamate
• CAS: 143558-79-6
• 化学式: C₁₀H₁₃NO₃
• 分子量: 195.218
• InChiKey: MKNMOUBCZXPUMW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  47.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  methyl 2-methoxybenzylcarbamate 在 lithium aluminium tetrahydride 作用下， 生成 2-甲氧基-N-甲基苄胺
  参考文献：
  名称：

  Intramolecular Addition of Stabilized Enolates to (η⁶-Arene)ruthenium Complexes:  Synthesis of Ru-Coordinated Azaspirocycles

  摘要：

  [GRAPHICS]Stabilized enolates attached to, cationic (arene)(RuCp)-Cp-II complexes via an amide linkage were found to participate in nucleophilic aromatic addition reactions resulting in the formation of novel cyclohexadienyl-Ru azaspirocycles. Enolate addition to the activated arene ring was found to proceed with complete stereoselectivity.

  DOI：

  10.1021/ol991123v
• 作为产物：
  描述：

  甲醇 、 2-(2-methoxyphenyl)acetyl azide 反应 48.0h， 生成 methyl 2-methoxybenzylcarbamate
  参考文献：
  名称：

  通过室温Curtius重排轻松制备受保护的苄基和杂芳基甲基胺

  摘要：

  描述了用于形成酰基叠氮化物以及随后的苯基和杂芳基乙酸的Curtius重排的分步室温过程。我们已经开发出了在MeOH或CHCl 3中进行室温Curtius重排的规程，该规程比标准条件有所改进，避免了使用添加剂或加热。Curtius重排的这种室温优化可防止形成通常在苯甲酸中观察到的副产物，从而可以使用各种苯甲基和杂芳基甲基胺。

  DOI：

  10.1016/j.tetlet.2010.03.101

文献信息

• AMIDE DERIVATIVE
  申请人：Nakahira Hiroyuki

  公开号：US20100056497A1

  公开（公告）日：2010-03-04

  The present invention relates to a compound of the formula (I) being useful as a renin inhibitor, or a pharmaceutically acceptable salt thereof. wherein R 1a is a hydrogen atom, an optionally substituted C 1-6 alkyl, etc.; R 1b is an optionally substituted C 1-6 alkoxy, etc.; R 1c is a hydrogen atom, an optionally substituted C 1-6 alkoxy, etc.; R 2 is a hydrogen atom, an optionally substituted C 1-6 alkyl, etc.; R 3a , R 3b , R 3c and R 3d are independently the same or different, and each is a group of the formula: -A-B (in which A is a single bond, —(CH 2 ) s O—, —(CH 2 ) s N(R 4 )CO—, etc., B is a hydrogen atom, an optionally substituted C 1-6 alkyl, etc.), etc.; R 4 is a hydrogen atom, an optionally substituted C 1-6 alkyl, etc.; s is 0, etc.; and n is 1, etc.

  本发明涉及一种具有式(I)的化合物，其可用作肾素抑制剂，或其药学上可接受的盐。其中，R1a是氢原子，可选地取代的C1-6烷基等；R1b是可选地取代的C1-6烷氧基等；R1c是氢原子，可选地取代的C1-6烷氧基等；R2是氢原子，可选地取代的C1-6烷基等；R3a，R3b，R3c和R3d独立且相同或不同，每个是式：-A-B的基团（其中A是单键，-(CH2)sO-，-( )sN(R4)CO-等，B是氢原子，可选地取代的C1-6烷基等）等；R4是氢原子，可选地取代的C1-6烷基等；s为0等；n为1等。
• Selective N-methylation of primary aliphatic amines with dimethyl carbonate in the presence of alkali cation exchanged Y-faujasites
  作者：Maurizio Selva、Pietro Tundo

  DOI：10.1016/j.tetlet.2003.09.016

  日期：2003.10

  The N-methylation of aliphatic amines [XC6H4(CH2)(n)NH2; n = 1, X = H (1a), o-MeO (1b), p-MeO (1c); n = 2, X = H (2a), o-MeO (2b); 1d: PhCH(Me)NH2] with dimethyl carbonate (DMC) is efficiently catalysed by NaY faujasite: on condition that CO2 (a co-product of the reaction) is carefully removed, N-methyl- and N,N-dimethyl-amines (RNHMe and RNMe2) are obtained in good overall yields (70-90%). Otherwise, in the presence Of CO2, carbamates (RNHCO2Me) form competitively to a large extent. The reaction probably proceeds through a B(Al)2 displacement of the amine on DMC. (C) 2003 Elsevier Ltd. All rights reserved.