(R)-2-(3-azido-1-phenylpropoxy)-4-chlorobenzonitrile | 357404-71-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (R)-2-(3-azido-1-phenylpropoxy)-4-chlorobenzonitrile
• 英文别名: 2-[[(1R)-3-azido-1-phenylpropyl]oxy]-4-chlorobenzonitrile；2-[(1R)-3-azido-1-phenylpropoxy]-4-chlorobenzonitrile
• CAS: 357404-71-8
• 化学式: C₁₆H₁₃ClN₄O
• 分子量: 312.758
• InChiKey: AECSGKMZSCXVRG-OAHLLOKOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  47.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (R)-2-(3-azido-1-phenylpropoxy)-4-chlorobenzonitrile 在 水 、 三苯基膦 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 生成 2-[[(1R)-3-amino-1-phenylpropyl]oxy]-4-chlorobenzonitrile
  参考文献：
  名称：

  The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS)

  摘要：

  By careful analysis of experimental X-ray ligand crystallographic protein data across several inhibitor series we have discovered a novel, potent and selective series of iNOS inhibitors exemplified by compound 8. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.02.061
• 作为产物：
  描述：

  (R)-(+)-3-氯-1-苯基-1-丙醇 生成 (R)-2-(3-azido-1-phenylpropoxy)-4-chlorobenzonitrile
  参考文献：
  名称：

  INHIBITORS OF NITRIC OXIDE SYNTHASES (NOS), PHARMACEUTICAL PRODUCTS THEREOF, AND METHODS THEREOF

  摘要：

  The present invention provides NOS inhibitors such as iNOS inhibitors, or a pharmaceutically acceptable salt, ester, prodrug, complex, solvate, hydrate, or isomer thereof, in any crystalline form or in amorphous form. The inhibitors include 1,1 or 1,2 substituted-ethyl carbamimido thioates, cyclic compounds substituted with a carbamimidoyl sulfanylethylphenyl group and a carbamimidoylsulfanyl group, compounds substituted with a carbamimidoyl sulfanylethyl phenylmethyl group, bis-carbamimidoylsulfanylethyl substituted compounds, 2-propoxypyridine derivatives, alkylamine or heteroalkylamine derivatives, n-aminoethyl n-phenyl amine derivatives, and saturated heterocyclic fused benzene derivatives. Pharmaceutical products comprising the NOS inhibitors such as iNOS inhibitors and the applications thereof in prophylaxis and/or treatment of inflammatory diseases, and proliferative diseases such as cancer including gastro-intestinal, colorectal, gynecological, pancreatic, head and neck, esophageal, breast, lung, and central nervous system tumors, among others, are also provided.

  公开号：

  US20230286913A1

文献信息

• Novel use of phenylheteroakylamine derivatives
  申请人：——

  公开号：US20030158185A1

  公开（公告）日：2003-08-21

  There is disclosed the use of a compound of formula (I) wherein R 1 , R 2 , X, Y, V, W and Z are as defined in the specification, and pharmaceutically acceptable salts, enantiomers or racemates thereof, in the manufacture of a medicament, for the treatment or prophylaxis of diseases or conditions in which inhibition of nitric oxide synthase activity is beneficial. Certain novel compounds of formula (Ia) and pharmaceutically acceptable salts thereof, and enantiomers and racemates thereof are disclosed; together with processes for their preparation, compositions containing them and their use in therapy. The compounds of formulae (I) and (Ia) are inhibitors of the enzyme nitric oxide synthase and are thereby particularly useful in the treatment or prophylaxis of inflammatory disease.

  公开了使用式（I）的化合物，其中R1、R2、X、Y、V、W和Z如规范中定义，并且其药学上可接受的盐、对映体或消旋体，在制备药物时用于治疗或预防抑制一氧化氮合酶活性有益的疾病或症状。公开了式（Ia）的某些新化合物及其药学上可接受的盐，以及其对映体和消旋体；以及它们的制备方法、含有它们的组合物以及它们在治疗中的应用。式（I）和（Ia）的化合物是一氧化氮合酶酶的抑制剂，因此在治疗或预防炎症性疾病方面特别有用。
• Oxazolidinone derivatives as potential antimicrobials
  申请人：——

  公开号：US20030119817A1

  公开（公告）日：2003-06-26

  The present invention relates to certain substituted phenyl oxazolidinones and to processes for the synthesis of the same. This invention also relates to pharmaceutical compositions containing the compounds of the present invention as antimicrobials. The compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiply-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms such as Bacterioides spp. and Clostridia spp. species, and acid fast organisms such as Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp.

  本发明涉及某些取代苯基噁唑烷酮以及其合成过程。本发明还涉及含有本发明化合物作为抗微生物药物的药物组合物。这些化合物是有用的抗微生物剂，对许多人类和兽医病原体具有有效作用，包括革兰氏阳性厌氧细菌，如多重耐药葡萄球菌，链球菌和肠球菌，以及厌氧微生物，如拟杆菌属和梭菌属物种，以及耐酸微生物，如结核分枝杆菌，分枝杆菌和分枝杆菌属。
• Oxazolidinone derivatives as antimicrobials disease
  申请人：——

  公开号：US20020103186A1

  公开（公告）日：2002-08-01

  The present invention relates to certain substituted phenyl oxazolidinones and to processes for the synthesis of the same. This invention also relates to pharmaceutical compositions containing the compounds of the present invention as antimicrobials. The compounds are useful antimicrobial agents, effec number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiply-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms such as Bacterioides spp. and Clostridia spp. species, and acid fast organisms such as Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp.

  本发明涉及某些取代苯基噁唑烷酮及其合成过程。本发明还涉及含有本发明化合物作为抗微生物药物的制药组合物。这些化合物是有用的抗微生物剂，可有效对抗多种人类和兽医病原体，包括革兰氏阳性厌氧菌如多重耐药葡萄球菌、链球菌和肠球菌，以及厌氧菌如Bacterioides spp.和Clostridia spp.种，和酸性快速生长菌如结核分枝杆菌、非结核分枝杆菌和分枝杆菌属。
• Oxazolidinone derivatives as antimicrobials
  申请人：——

  公开号：US20040254162A1

  公开（公告）日：2004-12-16

  The present invention relates to certain substituted phenyl oxazolidinones and to processes for the synthesis of the same. This invention also relates to pharma-ceutical compositions containing the compounds of the present invention as anti-microbials. The compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiply-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms such as Bacterioides spp. and Clostridia spp. species, and acid fast organisms such as Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp.

  本发明涉及某些取代苯基噁唑烷酮及其合成工艺。本发明还涉及含有本发明化合物作为抗微生物剂的医药组合物。本发明化合物是有用的抗微生物剂，可有效对抗多种人类和兽医病原体，包括革兰氏阳性需氧菌，如多重耐药葡萄球菌、链球菌和肠球菌，以及厌氧菌，如 细菌 和 梭状芽孢杆菌 等厌氧生物，以及酸性速生生物，如 结核分枝杆菌、禽分枝杆菌 和 分枝杆菌 等酸性快速生物。
• NOVEL USE OF PHENYLHETEROALKYLAMINE DERIVATIVES
  申请人：AstraZeneca AB

  公开号：EP1263711A1

  公开（公告）日：2002-12-11