(6S,8aR)-3-oxohexahydro-1H-oxazolo[3,4-a]pyridine-6-carboxylic acid | 1620675-53-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: (6S,8aR)-3-oxohexahydro-1H-oxazolo[3,4-a]pyridine-6-carboxylic acid
• 英文别名: (6S,8aR)-3-Oxohexahydro-3H-oxazolo[3,4-a]pyridine-6-carboxylic acid；(6S,8aR)-3-oxo-1,5,6,7,8,8a-hexahydro-[1,3]oxazolo[3,4-a]pyridine-6-carboxylic acid
• CAS: 1620675-53-7
• 化学式: C₈H₁₁NO₄
• 分子量: 185.18
• InChiKey: YHJROUBVTBKUDU-NTSWFWBYSA-N

物化性质

• 沸点：
  479.1±24.0 °C(Predicted)
• 密度：
  1.42±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  66.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (6S,8aR)-3-oxohexahydro-1H-oxazolo[3,4-a]pyridine-6-carboxylic acid 在 (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride 、 N-溴代丁二酰亚胺(NBS) 、 potassium carbonate 、 氯甲酸异丙酯 、 三乙胺 、 三氯氧磷 作用下， 以 1,4-二氧六环 、 N,N-二甲基甲酰胺 、 异丙醇 、 乙腈 为溶剂， 反应 28.0h， 生成 4-{8-amino-3-[(6R,8aS)-3-oxohexahydro[1,3]oxazolo[3,4-a]pyridin-6-yl]imidazo[1,5-a]pyrazin-1-yl}-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide
  参考文献：
  名称：

  Potent, non-covalent reversible BTK inhibitors with 8-amino-imidazo[1,5-a]pyrazine core featuring 3-position bicyclic ring substitutes

  摘要：

  Bruton's tyrosine kinase (BTK) is a Tec family kinase with a well-defined role in the B cell receptor (BCR) pathway. It has become an attractive kinase target for selective B cell inhibition, and for the treatment of B cell related diseases. Many BTK inhibitors have been discovered for the treatment of cancer and rheumatoid arthritis, including a series of BTK inhibitors based on 8-amino-imidazo[1,5-a]pyrazine we recently reported. The X-ray crystal structures of BTK with inhibitors were also published, which provided great help for the SAR design. Here we report our SAR work introducing ring constraints for the 3-position piperidine amides on the BTK inhibitors based on 8-amino-imidazo[1,5-a]pyrazine. This modification improved the potency in BTK inhibitions, as well as the PK profile and the off-target selectivity. The dose-dependent efficacy of two BTK inhibitors was observed in the rat collagen induced arthritis (CIA) model.

  DOI：

  10.1016/j.bmcl.2020.127390
• 作为产物：
  描述：

  5-(methoxycarbonyl)-2-methylpyridine 1-oxide 在 盐酸 、 水 、 sodium cyanoborohydride 、 碳酸氢钠 、 lithium hydroxide 作用下， 以 四氢呋喃 、 甲醇 、 溶剂黄146 为溶剂， 反应 97.0h， 生成 (6S,8aR)-3-oxohexahydro-1H-oxazolo[3,4-a]pyridine-6-carboxylic acid
  参考文献：
  名称：

  Potent, non-covalent reversible BTK inhibitors with 8-amino-imidazo[1,5-a]pyrazine core featuring 3-position bicyclic ring substitutes

  摘要：

  Bruton's tyrosine kinase (BTK) is a Tec family kinase with a well-defined role in the B cell receptor (BCR) pathway. It has become an attractive kinase target for selective B cell inhibition, and for the treatment of B cell related diseases. Many BTK inhibitors have been discovered for the treatment of cancer and rheumatoid arthritis, including a series of BTK inhibitors based on 8-amino-imidazo[1,5-a]pyrazine we recently reported. The X-ray crystal structures of BTK with inhibitors were also published, which provided great help for the SAR design. Here we report our SAR work introducing ring constraints for the 3-position piperidine amides on the BTK inhibitors based on 8-amino-imidazo[1,5-a]pyrazine. This modification improved the potency in BTK inhibitions, as well as the PK profile and the off-target selectivity. The dose-dependent efficacy of two BTK inhibitors was observed in the rat collagen induced arthritis (CIA) model.

  DOI：

  10.1016/j.bmcl.2020.127390
• 作为试剂：
  描述：

  (S)-methyl 2-(benzylamino)-3-((tert-butyldiphenylsilyl)oxy)propanoate 在 甲醇 、 N-溴代丁二酰亚胺(NBS) 、 锂硼氢 、 2,2,6,6-四甲基哌啶氧化物 、 碘苯二乙酸 、 (6S,8aR)-3-oxohexahydro-1H-oxazolo[3,4-a]pyridine-6-carboxylic acid 、 氢气 、 sodium methylate 、 lithium perchlorate 、 palladium(II) hydroxide 、 三乙胺 、 N,N-二异丙基乙胺 、 Methanaminium,N-[(dimethylamino)(3H-1,2,3-triazolo[4,5-b]pyridin-3-yloxy)methylene]-N-methyl-, hexafluorophosphate(1-) 、 三氯氧磷 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 乙醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 、 甲苯 、 乙腈 为溶剂， 50.0 ℃ 、344.75 kPa 条件下， 反应 181.75h， 生成 (2R,5R)-tert-butyl 2-(1-bromo-8-((2,4-dimethoxybenzyl)amino)imidazo[1,5-a]pyrazin-3-yl)-5-(((tert-butyldiphenylsilyl)oxy)methyl)morpholine-4-carboxylate
  参考文献：
  名称：

  [EN] BTK INHIBITORS
  [FR] INHIBITEURS DE BTK

  摘要：

  本发明提供了根据式(I)或其药学上可接受的盐的Bruton's酪氨酸激酶（Btk）抑制剂化合物。或其药学上可接受的盐，或包含这些化合物的药物组合物，以及它们在治疗中的应用。具体地，本发明涉及在治疗Btk介导的疾病中使用Btk抑制剂化合物。

  公开号：

  WO2014113932A1

文献信息

• BTK INHIBITORS
  申请人：KIM RONALD M.

  公开号：US20140206681A1

  公开（公告）日：2014-07-24

  The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula I or a pharmaceutically acceptable salt thereof or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds in the treatment of Btk mediated disorders.

  本发明提供了根据式I提供的Bruton's酪氨酸激酶（Btk）抑制剂化合物，或其药学上可接受的盐，或包含这些化合物的药物组合物，并且用于治疗的使用。具体地，本发明涉及在治疗Btk介导的疾病中使用Btk抑制剂化合物。
• US7342016B2
  申请人：——

  公开号：US7342016B2

  公开（公告）日：2008-03-11
• US9481682B2
  申请人：——

  公开号：US9481682B2

  公开（公告）日：2016-11-01