4,4',(5,5')-dibromo-2,2'-bi-1H-imidazole | 111852-03-0

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 芳基卤化物
• 英文名称: 4,4',(5,5')-dibromo-2,2'-bi-1H-imidazole
• 英文别名: 4,4'-dibromo-1(3)H,1'(3')H-[2,2']biimidazolyl；4,4'-Dibrom-1(3)H,1'(3')H-[2,2']biimidazolyl；5-bromo-2-(5-bromo-1H-imidazol-2-yl)-1H-imidazole
• CAS: 111852-03-0
• 化学式: C₆H₄Br₂N₄
• 分子量: 291.933
• InChiKey: CPEIJCFXDNXADY-UHFFFAOYSA-N

物化性质

• 熔点：
  >260 °C
• 沸点：
  549.0±48.0 °C(Predicted)
• 密度：
  2.242±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  57.4
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4,4',(5,5')-dibromo-2,2'-bi-1H-imidazole 在 硝酸 、 溶剂黄146 作用下， 生成 5,5'-dinitro-N⁴,N^4'-diphenyl-1(3)H,1'(3')H-[2,2']biimidazolyl-4,4'-diyldiamine
  参考文献：
  名称：

  Influence of Fat-Free Mass and Functional Status on Resting Energy Expenditure in Underweight Elders

  摘要：

  Background. In underweight elders, resting energy expenditure (REE) and its relationship with fat-tree mass (FFM) could be modified by sarcopenia. physical activity, and functional limitation. The aims Of this study were to investigate REE and its relationship with quantity and metabolic activity of FFM and to evaluate the influence of functional status oil REE ill underweight elderly subjects.Methods. Forty-eight underweight elders (BMI < 20) and 54 normal Weight elderly subjects (BMI 20-30) as a control group were selected. Body composition was determined by dual energy x-ray absorptiometry (DEXA). REE was measured by indirect calorimetry. Ability in activities of daily living, (ADLs) was assessed by the Katz index.Results. Underweight elders had significantly lower FFM. FFM index (FFM/height(2)), and REE than healthy Subject. REE adjusted for FFM with analysis of covariance remained significantly lower in the underweight group (1287 +/- 85 vs 1715 +/- 139 kcal/day in men, and 1124 +/- 63 vs 1366 +/- 91 kcal/day in women). Katz index in the underweight group was inverselv correlitted with REE (r = -0.68: p < .001) cven ittfei removid of FFNI. IFNI, and gender, by multiple regression analysis. In this model, FFM and Katz index together explained approximately 54% of REE variability.Conclusions. Underweight elderly subjects show it hypometabolism due to a reduction of both FFM quantity and its metabolic activity. Functional status in ADLs comes out its an important predictor of REE independently from FFM. The limited physical activity might be the underlying determinant of this hypometabolism, but further investigations are necessary to confirm this issue.

  DOI：

  10.1093/gerona/57.5.m302
• 作为产物：
  描述：

  联咪唑 在 N-溴代丁二酰亚胺(NBS) 、 氢溴酸 、 sodium hydride 作用下， 以 四氯化碳 为溶剂， 反应 9.0h， 生成 4,4',(5,5')-dibromo-2,2'-bi-1H-imidazole
  参考文献：
  名称：

  [2-（三甲基甲硅烷基）乙氧基]甲基（SEM）卤代保护的2,2'-Bi- H-咪唑

  摘要：

  2,2'-双1 ħ咪唑，当与受保护的[2-（三甲基硅基）乙氧基]甲基（SEM）保护基团，与治疗Ñ溴代琥珀酰亚胺或ñ氯琥珀酰亚胺的产率主要为单卤代衍生物4A和4B中。的[2-（三甲基硅基）乙氧基]甲基组随后被去除以得到纯的单卤代-2,2'-双ħ -咪唑2。

  DOI：

  10.1002/jhet.5570240328

文献信息

• MATTHEWS, D. P.;WHITTEN, J. P.;MCCARTHY, J. R., J. HETEROCYCL. CHEM., 24,(1987) N 3, 689-692
  作者：MATTHEWS, D. P.、WHITTEN, J. P.、MCCARTHY, J. R.

  DOI：——

  日期：——