(3,4-Dichlor-benzyliden)-triphenylphosphoran | 65627-09-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3,4-Dichlor-benzyliden)-triphenylphosphoran
• 英文别名: (3,4-Dichlorophenyl)methylene-triphenyl-$l^{5}-phosphane；(3,4-dichlorophenyl)methylidene-triphenyl-λ5-phosphane
• CAS: 65627-09-0
• 化学式: C₂₅H₁₉Cl₂P
• 分子量: 421.306
• InChiKey: VEXBPOLJJBFPAV-UHFFFAOYSA-N

物化性质

• 沸点：
  564.0±60.0 °C(Predicted)
• 密度：
  1.27±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  (3,4-Dichlor-benzyliden)-triphenylphosphoran 在 sodium hydride 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 、 mineral oil 为溶剂， 反应 7.5h， 生成 tert-butyl (R)-(4-(3,4-dichlorophenyl)-1-phenylbut-3-en-1-yl)(methyl)carbamate
  参考文献：
  名称：

  使用脯氨酸催化的（+）-舍曲林和（-）-CP-52002的简明对映选择性合成

  摘要：

  已经描述了（+）-舍曲林及其C 4差向异构体（-）-CP-52002的短对映选择性合成，其盐酸盐的总收率分别为30％。关键步骤是脯氨酸催化乙醛的曼尼希反应和酸催化烯烃的分子内Friedel-Crafts烷基化反应，并以高光学纯度进行。

  DOI：

  10.1016/j.tetlet.2016.01.085
• 作为产物：
  描述：

  3,4-二氯氯苄 在 potassium tert-butylate 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 反应 3.0h， 生成 (3,4-Dichlor-benzyliden)-triphenylphosphoran
  参考文献：
  名称：

  Novel inhibitors of bacterial two-component systems with gram positive antibacterial activity: Pharmacophore identification based on the screening hit closantel

  摘要：

  This SAR study has shown that the salicylanilide is the pharmacophore for inhibition of the bacteria! two-component system. Hydrophobic substituents improve the potency of inhibitors in this series; however, hydrophobicity is not the sole determinant for inhibition; structural and electronic requirements also exist. Closantel (1) was found to inhibit a two-component system and to have antibacterial activity against drug resistant S. aureus and E. faecium, (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00326-6

文献信息

• One-pot synthesis of gem-difluorostyrenes from benzyl bromide via olefination of phosphonium ylide with difluorocarbene
  作者：Xiao-Yun Deng、Jin-Hong Lin、Ji-Chang Xiao

  DOI：10.1016/j.jfluchem.2015.06.009

  日期：2015.11

  A new approach for the synthesis of gem-difluorostyrenes from benzyl bromide is described. Quaternization of triphenylphosphine with benzyl bromide to give phosphonium salts, deprotonation of the corresponding phosphonium salts to produce phosphonium ylide, and the subsequent olefination of phosphonium ylide with difluorocarbene generated from difluoromethylene phosphobetaine (Ph3P+CF2CO2−) by decarboxylation

  描述了一种由苄基溴合成宝石-二氟苯乙烯的新方法。的三苯基膦与苄基溴，得到鏻盐，相应的鏻盐，以产生磷叶立德，并与二氟卡宾从二氟亚甲基磷酸酯生成鏻内鎓盐的后续烯的脱质子化（PH季铵化3 P + CF 2 CO 2 -可以发生通过脱羧）在一个锅中平稳地进行，以高收率提供最终的宝石-二氟苯乙烯。
• Anti-proliferative evaluation of monoterpene derivatives against leukemia
  作者：Lekh Nath Gautam、Taotao Ling、Walter Lang、Fatima Rivas

  DOI：10.1016/j.ejmech.2016.02.034

  日期：2016.5

  The cure rate of pediatric acute lymphoblastic leukemia (ALL) has significantly improved in the past thirty years, however not all patient cohorts respond well to current chemotherapy regimens. Among the high risk patient cohort is infants with MLL-rearranged (MLL-r) B-ALL, which remains dismal with an overall survival rate <35%. Our program is interested in identifying new molecular scaffolds to better understand the underlying mechanisms and ultimately provide new targeted treatments. Based on a phenotypic screen, phenolic natural products were identified as promising scaffolds for further chemical evaluation. Herein we disclose the effects of a potent anti-proliferative compound 31 against human ALL leukemia cellular models. (C) 2016 Elsevier Masson SAS. All rights reserved.
• Ricciardi, Fiore J.; Doukas, Peter H., Heterocycles, 1986, vol. 24, # 4, p. 971 - 977
  作者：Ricciardi, Fiore J.、Doukas, Peter H.

  DOI：——

  日期：——
• Bicyclische Peroxide
  申请人：F. HOFFMANN-LA ROCHE AG

  公开号：EP0311955B1

  公开（公告）日：1993-04-21
• US4977184A
  申请人：——

  公开号：US4977184A

  公开（公告）日：1990-12-11