2,7-二溴-9,9-双(2-(2-(2-溴乙氧基)乙氧基)乙基)芴 | 1059697-76-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2,7-二溴-9,9-双(2-(2-(2-溴乙氧基)乙氧基)乙基)芴
• 英文名称: 2,7-dibromo-9,9-bis(2-(2-(2-bromoethoxy)ethoxy)ethyl)fluorene
• 英文别名: 2,7-Dibromo-9,9-bis(2-(2-(2-bromoethoxy)ethoxy)ethyl) fluorene；2,7-dibromo-9,9-bis[2-[2-(2-bromoethoxy)ethoxy]ethyl]fluorene
• CAS: 1059697-76-5
• 化学式: C₂₅H₃₀Br₄O₄
• 分子量: 714.127
• InChiKey: CBLVZYZTKLDDGR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  33
• 可旋转键数：
  16
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  36.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2,7-二溴-9,9-双(2-(2-(2-溴乙氧基)乙氧基)乙基)芴 在 bis-triphenylphosphine-palladium(II) chloride 、 copper(l) iodide 、 potassium carbonate 、 三苯基膦 作用下， 以 四氢呋喃 、 三乙胺 为溶剂， 反应 8.0h， 生成
  参考文献：
  名称：

  基于比例和时间分辨发光显微镜的低氧成像的铂（II）-乙炔基共轭聚电解质

  摘要：

  通过使用聚芴作为O 2不敏感的荧光团和Pt（II）络合物作为O 2敏感的磷光体，设计和合成了基于铂（II）-乙炔基的共轭聚电解质，可以生成共轭聚电解质纳米粒子（CPE-纳米粒子） ）由于其两亲结构而在水溶液中）。CPE纳米颗粒对O 2浓度显示出良好的敏感性，并且可以可逆地检测氧含量。通过在不同O 2下HeLa细胞中I green / I blue比值（0.18–0.85）的显着变化，证明了CPE纳米颗粒的细胞内比例O 2传感性能。水平。此外，通过时间分辨发光成像（TRLI）进行了O 2水平检测，以证明基于CPE纳米粒子的探针的准确性。CPE纳米粒子显示出高的磷光量子产率（19.98％）和氧猝灭效率（0.975），优于现有的O 2探针。CPE纳米颗粒已成功应用于光致发光寿命成像和时控发光成像中，以监测细胞内O 2的水平。

  DOI：

  10.1016/j.jorganchem.2018.10.014
• 作为产物：
  描述：

  三乙二醇 在 四丁基溴化铵 、 三溴化磷 、 potassium hydroxide 作用下， 以 二氯甲烷 为溶剂， 反应 24.42h， 生成 2,7-二溴-9,9-双(2-(2-(2-溴乙氧基)乙氧基)乙基)芴
  参考文献：
  名称：

  基于比例和时间分辨发光显微镜的低氧成像的铂（II）-乙炔基共轭聚电解质

  摘要：

  通过使用聚芴作为O 2不敏感的荧光团和Pt（II）络合物作为O 2敏感的磷光体，设计和合成了基于铂（II）-乙炔基的共轭聚电解质，可以生成共轭聚电解质纳米粒子（CPE-纳米粒子） ）由于其两亲结构而在水溶液中）。CPE纳米颗粒对O 2浓度显示出良好的敏感性，并且可以可逆地检测氧含量。通过在不同O 2下HeLa细胞中I green / I blue比值（0.18–0.85）的显着变化，证明了CPE纳米颗粒的细胞内比例O 2传感性能。水平。此外，通过时间分辨发光成像（TRLI）进行了O 2水平检测，以证明基于CPE纳米粒子的探针的准确性。CPE纳米粒子显示出高的磷光量子产率（19.98％）和氧猝灭效率（0.975），优于现有的O 2探针。CPE纳米颗粒已成功应用于光致发光寿命成像和时控发光成像中，以监测细胞内O 2的水平。

  DOI：

  10.1016/j.jorganchem.2018.10.014

文献信息

• A zwitterionic red-emitting water-soluble conjugated polymer with high resistance to nonspecific binding for two-photon cell imaging and good singlet oxygen production capability
  作者：Yan-Qin Huang、Shan-Shan Jiang、Li-Xiang Pan、Rui Zhang、Kun-Lin Liu、Xing-Fen Liu、Qu-Li Fan、Lian-Hui Wang、Wei Huang

  DOI：10.1039/d1nj01431e

  日期：——

  conjugated polymers (WSCPs) with the dual capability of two-photon imaging and singlet oxygen (1O2) production have become one of the most promising agents for noninvasive imaging guided photodynamic therapy (PDT). To obtain good imaging and PDT effects, two-photon excited (TPE) red-emitting WSCPs with good biocompatibility and 1O2 production capability are highly needed. Herein, a novel zwitterionic

  具有双光子成像和单线态氧 ( 1 O 2 ) 产生双重能力的水溶性共轭聚合物 (WSCP)已成为无创成像引导光动力疗法 (PDT) 最有前途的药物之一。为了获得良好的成像和 PDT 效果，非常需要具有良好生物相容性和1 O 2生产能力的双光子激发 (TPE) 发红光 WSCP 。在此，一种新型的两性离子发红光 WSCP P1''及其阳离子类似物P1'进行了合成和比较研究。两种聚合物的主链均由富电子聚[9,9'-双(2-(2-(2-溴乙氧基)乙氧基)乙基)芴-2,7-亚乙烯基]掺杂少量电子-缺乏发红光单元，4,7-双(2-噻吩基)-2,1,3-苯并噻二唑 (TBT)。既P1'和P1''实现TPE红色发射通过荧光共振能量转移（FRET）。然而，与P1'相比，P1''在生理环境中表现出更高的水溶性和对非特异性结合的抵抗力，这可能导致细胞摄取增加 5 倍。此外，双光子细胞成像实验表明，进入 HeLa
• Manganese porphyrin-incorporated conjugated polymer nanoparticles for T1-enhanced magnetic resonance and fluorescent imaging
  作者：Tianshe Yang、Wenguo Feng、Changyong Hu、Zhuang Lv、Huanjie Wei、Jiayang Jiang、Shujuan Liu、Qiang Zhao

  DOI：10.1016/j.ica.2017.06.014

  日期：2017.9

  Conjugated polymer nanoparticles (CPNs) possess many useful and fascinating properties, including high brightness, excellent photostability, good water-dispersibility, low cytotoxicity, and easy functionalization, showing promising application in bioimaging. In this work, one kind of optical/magnetic conjugated polyelectrolyte has been designed and synthesized by introducing Mn(III) porphyrin (T-1-weighted relaxivity) into a fluorescent fluorene based polymer backbone. Fluorescent/magnetic conjugated polymer nanoparticles (FM-CPNs) were prepared by self-assembly in the phosphate buffer solution caused by their amphiphilic structures with hydrophobic backbones and hydrophilic side chains. Their photophysical properties have been investigated in details via UV-vis absorption and fluorescent emission spectra. Investigation of its magnetic properties has shown that the FM-CPNs exhibit high T-1-weighted relaxivity value, making them promising candidates for T-1-enhanced magnetic resonance imaging agent. Further cell imaging has been realized successfully using FM-CPNs as staining label, and cytotoxicity was evaluated by the methyl thiazolyl tetrazolium (MTT) assay. (C) 2017 Published by Elsevier B.V.
• Mannose-Substituted Conjugated Polyelectrolyte and Oligomer as an Intelligent Energy Transfer Pair for Label-Free Visual Detection of Concanavalin A
  作者：Kan-Yi Pu、Jianbing Shi、Lihua Wang、Liping Cai、Guan Wang、Bin Liu

  DOI：10.1021/ma1021264

  日期：2010.12.14

  Mannose-substituted blue-fluorescent cationic conjugated polyelectrolyte (131) and yellow-fluorescent neutral conjugated oligomer (6) are synthesized via the combination of Suzuki coupling polymerization and click chemistry. The spectral overlap between the emission of P1 and the absorption of 6 allows one to blend them to form an intelligent fluorescence resonance energy transfer (FRET) pair for multicolor protein sensing. Despite the nonspecific-interaction-induced perturbation in the polymer emission, strong specific binding between mannose and Concanavalin A (ConA) is able to result in protein-selective FRET from PI to 6. The fluorescence of 6/P1 blend in the presence of ConA is dominated by yellow emission, while it remains blue in the presence of other six nonspecific proteins. The 6/P1 blend thus serves as a multicolor bicomponent FRET probe for label-free visual detection of ConA in a high-contrast and convenient manner. In addition, its linear ratiometric fluorescence response toward ConA enables effective protein quantification with a low limit of detection of similar to 1.5 nM. This study demonstrates the importance of molecular engineering in conjugated polyelectrolyte based label-free chemical and biological sensing.