2,7-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-9,9-bis(2-(2-(2-bromoethoxy)ethoxy) ethyl)fluorene | 1174011-99-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 2,7-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-9,9-bis(2-(2-(2-bromoethoxy)ethoxy) ethyl)fluorene
• 英文别名: 2-[9,9-bis[2-[2-(2-bromoethoxy)ethoxy]ethyl]-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)fluoren-2-yl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
• CAS: 1174011-99-4
• 化学式: C₃₇H₅₄B₂Br₂O₈
• 分子量: 808.261
• InChiKey: KYJWFBAXPFIPEJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.19
• 重原子数：
  49
• 可旋转键数：
  18
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  73.8
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  三乙二醇 在 (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride 、 四丁基溴化铵 、 potassium acetate 、 三溴化磷 、 potassium hydroxide 作用下， 以 1,4-二氧六环 、 二氯甲烷 、 水 为溶剂， 反应 18.0h， 生成 2,7-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-9,9-bis(2-(2-(2-bromoethoxy)ethoxy) ethyl)fluorene
  参考文献：
  名称：

  Manganese porphyrin-incorporated conjugated polymer nanoparticles for T1-enhanced magnetic resonance and fluorescent imaging

  摘要：

  Conjugated polymer nanoparticles (CPNs) possess many useful and fascinating properties, including high brightness, excellent photostability, good water-dispersibility, low cytotoxicity, and easy functionalization, showing promising application in bioimaging. In this work, one kind of optical/magnetic conjugated polyelectrolyte has been designed and synthesized by introducing Mn(III) porphyrin (T-1-weighted relaxivity) into a fluorescent fluorene based polymer backbone. Fluorescent/magnetic conjugated polymer nanoparticles (FM-CPNs) were prepared by self-assembly in the phosphate buffer solution caused by their amphiphilic structures with hydrophobic backbones and hydrophilic side chains. Their photophysical properties have been investigated in details via UV-vis absorption and fluorescent emission spectra. Investigation of its magnetic properties has shown that the FM-CPNs exhibit high T-1-weighted relaxivity value, making them promising candidates for T-1-enhanced magnetic resonance imaging agent. Further cell imaging has been realized successfully using FM-CPNs as staining label, and cytotoxicity was evaluated by the methyl thiazolyl tetrazolium (MTT) assay. (C) 2017 Published by Elsevier B.V.

  DOI：

  10.1016/j.ica.2017.06.014

文献信息

• Mannose-Substituted Conjugated Polyelectrolyte and Oligomer as an Intelligent Energy Transfer Pair for Label-Free Visual Detection of Concanavalin A
  作者：Kan-Yi Pu、Jianbing Shi、Lihua Wang、Liping Cai、Guan Wang、Bin Liu

  DOI：10.1021/ma1021264

  日期：2010.12.14

  Mannose-substituted blue-fluorescent cationic conjugated polyelectrolyte (131) and yellow-fluorescent neutral conjugated oligomer (6) are synthesized via the combination of Suzuki coupling polymerization and click chemistry. The spectral overlap between the emission of P1 and the absorption of 6 allows one to blend them to form an intelligent fluorescence resonance energy transfer (FRET) pair for multicolor protein sensing. Despite the nonspecific-interaction-induced perturbation in the polymer emission, strong specific binding between mannose and Concanavalin A (ConA) is able to result in protein-selective FRET from PI to 6. The fluorescence of 6/P1 blend in the presence of ConA is dominated by yellow emission, while it remains blue in the presence of other six nonspecific proteins. The 6/P1 blend thus serves as a multicolor bicomponent FRET probe for label-free visual detection of ConA in a high-contrast and convenient manner. In addition, its linear ratiometric fluorescence response toward ConA enables effective protein quantification with a low limit of detection of similar to 1.5 nM. This study demonstrates the importance of molecular engineering in conjugated polyelectrolyte based label-free chemical and biological sensing.