2,4-二氯烟酰胺 | 70593-56-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 2,4-二氯烟酰胺
• 英文名称: 2,4-dichloro-nicotinic acid amide
• 英文别名: 2,4-Dichlor-nicotinsaeure-amid；2,4-Dichloropyridine-3-carboxamide
• CAS: 70593-56-5
• 化学式: C₆H₄Cl₂N₂O
• 分子量: 191.017
• InChiKey: SBNBNPZOICXBQI-UHFFFAOYSA-N

物化性质

• 熔点：
  182 °C
• 沸点：
  288.4±40.0 °C(Predicted)
• 密度：
  1.524±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  56
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2933399090

反应信息

• 作为反应物：
  描述：

  2,4-二氯烟酰胺 在 三氯氧磷 作用下， 生成 2,4-二氯-3-氰基吡啶
  参考文献：
  名称：

  Spaeth; Koller, Chemische Berichte, 1923, vol. 56, p. 2457

  摘要：

  DOI：
• 作为产物：
  描述：

  2,4-二氯吡啶-3-甲酰氯 在 ammonium hydroxide 作用下， 以 四氢呋喃 为溶剂， 以100%的产率得到2,4-二氯烟酰胺
  参考文献：
  名称：

  Identification of aminopyrazolopyridine ureas as potent VEGFR/PDGFR multitargeted kinase inhibitors

  摘要：

  Tumor angiogenesis is mediated by KDR and other VEGFR and PDGFR kinases. Their inhibition presents an attractive approach for developing anticancer therapeutics. Here, we report a series of aminopyrazolopyridine ureas as potent VEGFR/PDGFR multitargeted kinase inhibitors. A number of compounds have been identified to be orally bioavailable and efficacious in the mouse edema model. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.10.018

文献信息

• [EN] BICYCLIC INHIBITORS OF ALK<br/>[FR] INHIBITEURS BICYCLIQUES DE L'ALK
  申请人：ABBOTT LAB

  公开号：WO2012097683A1

  公开（公告）日：2012-07-26

  The present invention relates to compounds of formula (1) or pharmaceutical acceptable salts, Formula (1) wherein R1, R2, R3, X, Y, Z, A, B, G1, m, and n are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as ALK and methods of treating diseases such as cancer.

  本发明涉及化合物的公式（1）或药用可接受盐，公式（1）中R1、R2、R3、X、Y、Z、A、B、G1、m和n的定义在说明中。本发明还涉及含有上述化合物的组合物，用于抑制激酶如ALK并治疗癌症等疾病的方法。
• Azolylmethyloxiranes, Their Use for Controlling Phytopathogenic Fungi and Agents Containing Said Compounds
  申请人：Dietz Jochen

  公开号：US20090197929A1

  公开（公告）日：2009-08-06

  The present invention relates to azolylmethyloxiranes of the general formula I in which A or B is a 5-membered heteroaryl selected from the group consisting of thienyl, furyl, pyrrolyl, pyrazolyl, imidazolyl, oxazolyl, thiazolyl, isoxazolyl and isothiazolyl which is substituted by one to three of the following substituents: halogen, NO 2 , amino, C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy, C 1 -C 4 -haloalkyl, C 1 -C 4 -haloalkoxy, C 1 -C 4 -alkylamino, C 1 -C 4 -dialkylamino, thio or C 1 -C 4 -alkylthio, and the respective other substituent A or B is phenyl which is optionally substituted by one to three of the following substituents: halogen, NO 2 , amino, C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy, C 1 -C 4 -haloalkyl, C 1 -C 4 -haloalkoxy, C 1 -C 4 -alkylamino, C 1 -C 4 -dialkylamino, thio or C 1 -C 4 -alkylthio, and to the plant-compatible acid addition salts or metal salts thereof, to the use of the compounds of the formula I for controlling phytopathogenic fungi and to compositions comprising these compounds.

  本发明涉及通式I的唑基甲氧环氧乙烷，其中A或B是从噻吩基、呋喃基、吡咯基、吡唑基、咪唑基、噁唑基、噻唑基、异噁唑基和异噻唑基中选择的5-成员杂芳基，该基团被以下一种或三种取代基所取代：卤素、NO2、氨基、C1-C4-烷基、C1-C4-烷氧基、C1-C4-卤代烷基、C1-C4-卤代烷氧基、C1-C4-烷基氨基、C1-C4-二烷基氨基、硫醚或C1-C4-烷基硫醚；另一取代基A或B是苯基，该苯基可以选配地被以下一种或三种取代基所取代：卤素、NO2、氨基、C1-C4-烷基、C1-C4-烷氧基、C1-C4-卤代烷基、C1-C4-卤代烷氧基、C1-C4-烷基氨基、C1-C4-二烷基氨基、硫醚或C1-C4-烷基硫醚；以及与之相关的植物兼容酸盐或金属盐，以及用于控制植物病原真菌的通式I化合物的用途和包含这些化合物的组合物。
• [EN] INHIBITORS OF INFLUENZA VIRUS REPLICATION AND USES THEREOF<br/>[FR] INHIBITEURS DE RÉPLICATION DU VIRUS DE LA GRIPPE ET UTILISATIONS ASSOCIÉES
  申请人：SUNSHINE LAKE PHARMA CO LTD

  公开号：WO2018127096A1

  公开（公告）日：2018-07-12

  Provided herein is inhibitors of influenza virus replication and uses thereof. Specifically, provided herein a novel class of compounds as inhibitors of influenza virus replication, preparation methods thereof, pharmaceutical compositions containing these compounds, and uses of these compounds and pharmaceutical compositions thereof in the treatment of influenza.

  本文提供了流感病毒复制的抑制剂及其用途。具体来说，本文提供了一种新型化合物类别作为流感病毒复制的抑制剂，其制备方法，含有这些化合物的药物组合物，以及这些化合物和药物组合物在治疗流感中的用途。
• Imidazole and Triazole Compounds, Use Thereof and Agents Containing Said Compounds
  申请人：Renner Jens

  公开号：US20110166020A1

  公开（公告）日：2011-07-07

  The present invention relates to compounds of the formula I in which the variables have the meanings defined in the claims and in the description.

  本发明涉及公式I的化合物，其中变量的含义定义在权利要求和说明书中。
• Thioamides and Salts Thereof and Cytokine Production Inhibitors Containing Both
  申请人：Kato Fuminori

  公开号：US20070219215A1

  公开（公告）日：2007-09-20

  To provide cytokine production inhibitors useful as preventive or therapeutic medicines for diseases accompanied by hyperactivated immune functions. A cytokine production inhibitor containing, as an active ingredient, a thioamide compound represented by the formula (I) or a salt thereof: wherein A is N, NO, C—NO 2 or C—CN; Hal is a halogen; M 1 is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, heterocyclyl, amino, O, S, SO or SO 2 ; M 2 is amino, O, S or a single bond; R 1 is a halogen, alkyl or the like; each of R 2 , R 3 , R 4 and R 5 is independently H, alkyl or the like; R 6 is a halogen, alkyl or the like; Cy is cycloalkyl, cycloalkenyl, aryl or heterocyclyl; each of k, p and q is independently an integer of from 0 to 3; and r is an integer of from 0 to 5.

  提供细胞因子产生抑制剂，用作预防或治疗伴随有免疫功能过度活化的疾病的药物。一种包含硫酰胺化合物或其盐的细胞因子产生抑制剂，所述硫酰胺化合物由式（I）表示：其中，A为N、NO、C—NO2或C—CN；Hal为卤素；M1为烷基、烯基、炔基、环烷基、环烯基、芳基、杂环基、氨基、O、S、SO或SO2；M2为氨基、O、S或单键；R1为卤素、烷基或类似物；R2、R3、R4和R5中的每一个独立地为H、烷基或类似物；R6为卤素、烷基或类似物；Cy为环烷基、环烯基、芳基或杂环基；k、p和q中的每一个独立地为0到3的整数；r为0到5的整数。