N,N'-(2,2'-[2,2'-oxybis[ethoxy]]bis(ethoxy))diphthalimide | 159655-95-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: N,N'-(2,2'-[2,2'-oxybis[ethoxy]]bis(ethoxy))diphthalimide
• 英文别名: 1,11-diphthalimidooxy-3,6,9-trioxaundecane；2-{2-[2-(2-{2-[(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-YL)oxy]ethoxy}ethoxy)ethoxy]ethoxy}-1H-isoindole-1,3(2H)-dione；2-[2-[2-[2-[2-(1,3-dioxoisoindol-2-yl)oxyethoxy]ethoxy]ethoxy]ethoxy]isoindole-1,3-dione
• CAS: 159655-95-5
• 化学式: C₂₄H₂₄N₂O₉
• 分子量: 484.463
• InChiKey: KTQNKGXXCHZLSR-UHFFFAOYSA-N

物化性质

• 沸点：
  646.6±65.0 °C(Predicted)
• 密度：
  1.43±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  35
• 可旋转键数：
  14
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  121
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  N,N'-(2,2'-[2,2'-oxybis[ethoxy]]bis(ethoxy))diphthalimide 在 次氯酸叔丁酯 、 一水合肼 、 三乙胺 作用下， 以 丙醇 、 氯仿 、 乙腈 为溶剂， 反应 10.08h， 生成 1,11-di(N-chloro-N',N'-dimethylcarbamoylaminooxy)-3,6,9-trioxaundecane
  参考文献：
  名称：

  Shtamburg, V. G.; Dmitrenko, A. A.; Pleshkova, A. P., Russian Journal of Organic Chemistry, 1993, vol. 29, # 9.1, p. 1464 - 1470

  摘要：

  DOI：
• 作为产物：
  描述：

  N-羟基邻苯二甲酰亚胺 、 1-溴-2-(2-(2-(2-溴乙氧基)乙氧基)乙氧基)乙烷 在 三乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 720.0h， 以64.3%的产率得到N,N'-(2,2'-[2,2'-oxybis[ethoxy]]bis(ethoxy))diphthalimide
  参考文献：
  名称：

  Shtamburg, V. G.; Dmitrenko, A. A.; Pleshkova, A. P., Russian Journal of Organic Chemistry, 1993, vol. 29, # 9.1, p. 1464 - 1470

  摘要：

  DOI：

文献信息

• Chemoselective Capture of Glycans for Analysis on Gold Nanoparticles: Carbohydrate Oxime Tautomers Provide Functional Recognition by Proteins
  作者：Mikkel B. Thygesen、Jørgen Sauer、Knud J. Jensen

  DOI：10.1002/chem.200801521

  日期：2009.2.2

  Open or closed: N‐Glycosyl oxyamine versus open‐chain glycosyl oxime is the key to protein recognition on glyconanoparticles. Unprotected glycans are captured by oxime formation with a novel bifunctional reagent and the resulting glycan‐linker conjugates are anchored to gold nanoparticles (AuNPs). These glyconanoparticles maintain the structural integrity of glycans in the study of protein–carbohydrate

  开式或闭式：N-糖基氧胺与开链糖基肟的关系是在糖纳米颗粒上识别蛋白质的关键。未被保护的聚糖被一种新型的双功能试剂通过肟形成而捕获，并将生成的聚糖-连接物偶联物锚定在金纳米颗粒（AuNPs）上。这些糖纳米颗粒在蛋白质与碳水化合物相互作用的研究中保持了聚糖的结构完整性（见图）。
• Synthesis and Antiviral Activity of Dimeric Capsid-Binding Inhibitors of Human Rhinovirus (HRV)
  作者：Guy Y. Krippner、David K. Chalmers、Pauline C. Stanislawski、Simon P. Tucker、Keith G. Watson

  DOI：10.1071/ch03295

  日期：——

  A set of dimeric analogues of known rhinovirus capsid-binders Pleconaril 1 and Pirodavir 55 has been synthesized and tested against two representative human rhinovirus (HRV) strains. Dimers with linker lengths ranging from five atoms up to approximately 60 atoms were prepared by coupling various functionalized monomeric precursors. Many of the dimers showed activity against HRV, with the most active compounds being those with the shorter linking groups. The lower activity of all the dimers relative to similar monomeric compounds, and especially the low activity of the longest dimers, suggests that cooperative bivalent binding is not occurring with any of these compounds.

  我们合成了一组已知鼻病毒荚膜结合剂 Pleconaril 1 和 Pirodavir 55 的二聚体类似物，并针对两种具有代表性的人类鼻病毒（HRV）毒株进行了测试。通过偶联各种功能化单体前体，制备出了链接长度从 5 个原子到约 60 个原子不等的二聚体。许多二聚体都显示出了抗 HRV 的活性，其中连接基团较短的化合物活性最高。与类似的单体化合物相比，所有二聚体的活性都较低，尤其是最长二聚体的活性较低，这表明这些化合物都没有发生合作性二价结合。
• A model study for tethering of (bio)active molecules to biomaterial surfaces through arginine
  作者：F. Taraballi、L. Russo、C. Battocchio、G. Polzonetti、F. Nicotra、L. Cipolla

  DOI：10.1039/c4ob00160e

  日期：——

  A new approach for tethering of bioactive molecules via arginine is proposed and validated on collagen 2D matrices. The method involves the introduction of a methyl ketone on arginine side-chains, followed by reaction with model alkoxyamino derivatives.

  提出了一种通过精氨酸束缚生物活性分子的新方法，并在2D胶原蛋白基质上得到了验证。该方法包括在精氨酸侧链上引入甲基酮，然后与模型烷氧基氨基衍生物反应。
• Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
  申请人：Ambrx, Inc.

  公开号：EP2399893A2

  公开（公告）日：2011-12-28

  Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one oximine, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.

  本文公开了非天然氨基酸和包括至少一种非天然氨基酸的多肽，以及制造这种非天然氨基酸和多肽的方法。非天然氨基酸本身或作为多肽的一部分，可包括多种可能的官能团，但典型的至少有一个肟基、羰基、二羰基和/或羟胺基。本文还公开了经翻译后进一步修饰的非天然氨基酸多肽、进行此类修饰的方法以及纯化此类多肽的方法。通常，修饰的非天然氨基酸多肽包括至少一个肟基、羰基、二羰基和/或羟胺基团。进一步公开的是使用这种非天然氨基酸多肽和修饰的非天然氨基酸多肽的方法，包括治疗、诊断和其它生物技术用途。
• COMPOSITIONS CONTAINING, METHODS INVOLVING, AND USES OF NON-NATURAL AMINO ACIDS AND POLYPEPTIDES
  申请人：Ambrx, Inc.

  公开号：EP1828224B1

  公开（公告）日：2016-04-06