6-(4-bromo-phenyl)-4-hydrazino-2-thioxo-1,2-dihydropyrimidine-5-carbonitrile | 1333074-73-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 6-(4-bromo-phenyl)-4-hydrazino-2-thioxo-1,2-dihydropyrimidine-5-carbonitrile
• 英文别名: 6-(4-bromophenyl)-4-hydrazinyl-2-sulfanylidene-1H-pyrimidine-5-carbonitrile
• CAS: 1333074-73-9
• 化学式: C₁₁H₈BrN₅S
• 分子量: 322.188
• InChiKey: UDJHTSWQQZHVIB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  118
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6-(4-bromo-phenyl)-4-hydrazino-2-thioxo-1,2-dihydropyrimidine-5-carbonitrile 在 盐酸 、 sodium nitrite 作用下， 以 水 为溶剂， 反应 4.25h， 以54%的产率得到7-(4-bromo-phenyl)-5-thioxo-5,6-dihydrotetrazolo [1,5-c] pyrimidine-8-carbonitrile
  参考文献：
  名称：

  Synthesis, antimicrobial, antioxidant activities of novel 6-aryl-5-cyano thiouracil derivatives

  摘要：

  A series of 6-aryl-5-cyano thiouracil derivatives (2a-c to ha-c) was synthesized from 6-ary1-4hydrazino-2-thioxo-1,2-dihydropyrimidine-5-carbonitriles (la-c).The products were characterized by analytical and spectral data (IR, 1H NMR, 13C NMR and mass spectra). All compounds were screened for their in-vitro antibacterial and antifungal activities. Compounds 7a, 7g and 9a-c showed pronounced antimicrobial activity than standards. Some of the newly synthesized compounds were evaluated for antioxidant activity. Compounds lc, 5c and 8c displayed promising free radical scavenging activity and found to be more potent than standard, ascorbic acid (vitamin C). (C) 2013 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2013.08.032
• 作为产物：
  描述：

  5-cyano-6-(4-bromophenyl)-2-thiopyrimidinone 在 五氯化磷 、 一水合肼 、 三氯氧磷 作用下， 以 甲醇 为溶剂， 反应 0.33h， 生成 6-(4-bromo-phenyl)-4-hydrazino-2-thioxo-1,2-dihydropyrimidine-5-carbonitrile
  参考文献：
  名称：

  Synthesis, antimicrobial, antioxidant activities of novel 6-aryl-5-cyano thiouracil derivatives

  摘要：

  A series of 6-aryl-5-cyano thiouracil derivatives (2a-c to ha-c) was synthesized from 6-ary1-4hydrazino-2-thioxo-1,2-dihydropyrimidine-5-carbonitriles (la-c).The products were characterized by analytical and spectral data (IR, 1H NMR, 13C NMR and mass spectra). All compounds were screened for their in-vitro antibacterial and antifungal activities. Compounds 7a, 7g and 9a-c showed pronounced antimicrobial activity than standards. Some of the newly synthesized compounds were evaluated for antioxidant activity. Compounds lc, 5c and 8c displayed promising free radical scavenging activity and found to be more potent than standard, ascorbic acid (vitamin C). (C) 2013 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2013.08.032

文献信息

• Synthesis, antimicrobial, antioxidant activities of novel 6-aryl-5-cyano thiouracil derivatives
  作者：M.S. Mohamed、M.M. Youns、N.M. Ahmed

  DOI：10.1016/j.ejmech.2013.08.032

  日期：2013.11

  A series of 6-aryl-5-cyano thiouracil derivatives (2a-c to ha-c) was synthesized from 6-ary1-4hydrazino-2-thioxo-1,2-dihydropyrimidine-5-carbonitriles (la-c).The products were characterized by analytical and spectral data (IR, 1H NMR, 13C NMR and mass spectra). All compounds were screened for their in-vitro antibacterial and antifungal activities. Compounds 7a, 7g and 9a-c showed pronounced antimicrobial activity than standards. Some of the newly synthesized compounds were evaluated for antioxidant activity. Compounds lc, 5c and 8c displayed promising free radical scavenging activity and found to be more potent than standard, ascorbic acid (vitamin C). (C) 2013 Elsevier Masson SAS. All rights reserved.