2,6-双(溴甲基)-4-碘吡啶 | 106967-33-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 2,6-双(溴甲基)-4-碘吡啶
• 英文名称: 2,6-bis(bromomethyl)-4-iodopyridine
• CAS: 106967-33-3
• 化学式: C₇H₆Br₂IN
• 分子量: 390.844
• InChiKey: QMQSLEDQBRQOQS-UHFFFAOYSA-N

物化性质

• 熔点：
  147-149 °C(Solv: acetone (67-64-1))
• 沸点：
  359.1±42.0 °C(Predicted)
• 密度：
  2.387±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2,6-双(溴甲基)-4-碘吡啶 在 copper(l) iodide 、 bis(triphenylphosphine)palladium(II)-chloride 、 sodium carbonate 、 三乙胺 、 三氟乙酸 作用下， 以 乙腈 为溶剂， 反应 30.5h， 生成 4-(phenylethynyl)-2,6-bispyridine
  参考文献：
  名称：

  Takalo, Harri; Pasanen, Paavo; Kankare, Jouko, Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry, 1988, vol. 42, # 6, p. 373 - 377

  摘要：

  DOI：
• 作为产物：
  描述：

  4-iodo-2,6-pyridinedicarboxylic acid dimethyl ester 在 sodium tetrahydroborate 、 乙醇 、 三溴化磷 作用下， 以 氯仿 为溶剂， 反应 32.5h， 生成 2,6-双(溴甲基)-4-碘吡啶
  参考文献：
  名称：

  Luminescent Carbazole-Based Eu^III and Yb^III Complexes with a High Two-Photon Absorption Cross-Section Enable Viscosity Sensing in the Visible and Near IR with One- and Two-Photon Excitation

  摘要：

  The newly synthesized Eu(III )and Yb-III complexes with the new carbazole-based ligands CPAD(2-) and CPAP(4-) display the characteristic long-lived metal-centered emission upon one- and two-photon excitation. The Eu(III )complexes show the expected narrow emission bands in the red region, with emission lifetimes between 0.382 and 1.464 ms and quantum yields between 2.7% and 35.8%, while the Yb-III complexes show the expected emission in the NIR region, with emission lifetimes between 0.52 and 37.86 mu s and quantum yields between 0.028% and 1.12%. Two-photon absorption cross sections (sigma 2(PA)) as high as 857 GM were measured for the two ligands. The complexes showed a strong dependence of the one- and two-photon sensitized emission intensity on solvent viscosity in the range of 0.5-200 cP in the visible and NIR region.

  DOI：

  10.1021/acs.inorgchem.9b03561

文献信息

• NOVEL LUMINESCENT LANTHANIDE CHELATES WITH ENHANCED EXCITATION PROPERTIES
  申请人：DHR Finland OY

  公开号：US20130183771A1

  公开（公告）日：2013-07-18

  The present application discloses a luminescent lanthanide chelate comprising one or more chromophoric moieties of the formula (I) or of the formula (III) wherein R 1 , R 2 and R 2* each independently are selected from carbon-containing substituents forming a C—O bond with the neighbouring oxygen atom, R 3 and R 4 each represent a bond between the chromophoric moiety and other moieties of the chelate, and Ln 3+ is a lanthanide ion, as well as the corresponding luminescence lanthanide chelating ligand. The application also discloses a detectable molecule comprising a biospecific binding reactant (such as an antibody) conjugated to the luminescent lanthanide chelate as well as a method of carrying out a biospecific binding assay, the use of such a detectable molecule in a specific bioaffinity based binding assay utilizing time-resolved fluorometric determination of a specific luminescence, and a solid support material conjugated with the luminescent lanthanide chelate.

  本申请公开了一种发光镧系螯合物，包括一个或多个具有以下式(I)或式(III)的色团基团，其中R1、R2和R2*各自独立地选自与相邻氧原子形成C—O键的含碳取代基，R3和R4分别代表色团基团与螯合物的其他基团之间的键，Ln3+是镧系离子，以及相应的发光镧系螯合配体。该申请还公开了一种可检测的分子，包括与发光镧系螯合物结合的生物特异性结合试剂（如抗体），以及进行生物特异性结合测定的方法，利用这种可检测的分子在利用时间分辨荧光确定特定发光的特定生物亲和性结合测定中的应用，以及与发光镧系螯合物结合的固体支持材料。
• Fluorescent lanthanide chelates
  申请人：——

  公开号：US04920195A1

  公开（公告）日：1990-04-24

  A fluorescing lanthanide chelate of a lanthanide cation and a compound having the structure ##STR1## where X.sup.3, X.sup.4 and X.sup.5 that may be the same or different, each denotes a substituted ethynyl group, hydrogen, an alkyl group, an aryl group, a hydroxyl group, an alkoxyl group or an amino group, wherein at least one of X.sup.3, X.sup.4 and X.sup.5 denotes a substituted ethynyl group, and Z.sup.2 and Z.sup.6 that may be the same or different, each denotes a chelating group, hydrogen, an alkyl group or an amino group, wherein at least one of Z.sup.2 and Z.sup.6 denotes a chelating group.

  一种荧光镧系配合物，包括镧离子和具有以下结构的化合物：##STR1## 其中，X.sup.3，X.sup.4和X.sup.5可能相同也可能不同，每个表示取代乙炔基，氢，烷基，芳基，羟基，烷氧基或氨基，其中至少一个X.sup.3，X.sup.4和X.sup.5表示取代乙炔基；Z.sup.2和Z.sup.6可能相同也可能不同，每个表示螯合基，氢，烷基或氨基，其中至少一个Z.sup.2和Z.sup.6表示螯合基。
• Synthesis and Hydrolysis of 4-Chloro-PyMTA and 4-Iodo-PyMTA Esters and Their Oxidative Degradation with Cu(I/II) and Oxygen
  作者：Adelheid Godt、Mian Qi、Miriam Hülsmann

  DOI：10.1055/s-0035-1561660

  日期：——

  4 H+]4– (basic hydrolysis) and PyMTA (acidic hydrolysis), was determined to be 90–94 wt % by 1H NMR spectroscopy using maleic acid as an internal standard. The tert-butyl esters were easily hydrolyzed with aqueous alkali hydroxide, with a decreasing rate in the series NaOH, KOH, LiOH. This finding indicates a Lewis acid assisted ester cleavage with the Na+ ion fitting best to the multidentate ligand

  摘要 我们公开了从市场上可得的氯膦酸一水合物以4-36％的总收率合成4-氯-PyMTA和4-碘-PyMTA的乙基和叔丁基酯的方法。另外，据报道用NaOH水溶液（乙酯）或三氟乙酸（叔丁酯）水解酯。所得材料包含4-卤代-PyMTA与部分去质子化或部分质子化的4-卤代-PyMTA的混合物。表示为当前物种常见结构基序的配体含量，即[PyMTA – 4 H + ] 4–（碱性水解）和PyMTA（酸性水解），经1 H测定为90–94 wt％使用马来酸作为内标的NMR光谱。该叔丁酸酯很容易被氢氧化碱水溶液水解，并且在NaOH，KOH，LiOH系列中降低的速率。这一发现表明路易斯酸辅助的酯裂解，其Na +离子最适合多齿配体。出乎意料的是，PyMTA酯在氧气存在下与Cu（I / II）盐不相容。在这些条件下，两个氨基甲基之一被转化成甲酰基。该反应不仅限制了Cu（I / II）催化反应的应用，而且还需要在材料
• Luminescent Lanthanide Chelates Having Three Chromophores and Their Use
  申请人：Meltola Niko

  公开号：US20130210165A1

  公开（公告）日：2013-08-15

  The present application discloses a luminescent lanthanide chelate of formula (I) with lanthanides such as europium, as well as the corresponding luminescence lanthanide chelating ligand. The application also discloses a detectable molecule comprising a biospecific binding reactant (such as an antibody) conjugated to the luminescent lanthanide chelate as well as a method of carrying out a biospecific binding assay, the use of such a detectable molecule in a specific bioaffinity based binding assay utilizing time-resolved fluorometric determination of a specific luminescence, and a solid support material conjugated with the luminescent lanthanide chelate.

  本申请公开了一种具有镧系元素（如铕）的荧光配合物(I)的配合物，以及相应的荧光镧系螯合配体。该申请还公开了一种检测分子，包括与荧光镧系配合物偶联的生物特异性结合反应物（如抗体），以及进行生物特异性结合测定的方法，使用这种检测分子在利用时间分辨荧光测定特定荧光的特定生物亲和性基础结合测定中，以及与荧光镧系螯合物偶联的固体支持材料的使用。
• TAKALO, HARRI;PASANEN, PAAVO;KANKARE, JOUKO, ACTA CHEM. SCAND. B., 42,(1988) N 6, C. 373-377
  作者：TAKALO, HARRI、PASANEN, PAAVO、KANKARE, JOUKO

  DOI：——

  日期：——