N,N-二异丙基-4-甲氧基吡啶甲酰胺 | 446019-94-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: N,N-二异丙基-4-甲氧基吡啶甲酰胺
• 英文名称: 4-methoxy-2-pyridine carboxylic acid N,N-diisopropylamide
• 英文别名: N,N-diisopropyl-4-methoxy-2-picolinamide；N,N-Diisopropyl-4-methoxypicolinamide；4-methoxy-N,N-di(propan-2-yl)pyridine-2-carboxamide
• CAS: 446019-94-9
• 化学式: C₁₃H₂₀N₂O₂
• 分子量: 236.314
• InChiKey: YFXZFQIMLQYBCM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  42.4
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 危险等级：
  IRRITANT
• 海关编码：
  2933399090

反应信息

• 作为反应物：
  描述：

  N,N-二异丙基-4-甲氧基吡啶甲酰胺 在 copper(l) iodide 、 正丁基锂 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 反应 6.67h， 生成 4,5-dimethoxy-2-pyridine carboxylic acid N,N-diisopropylamide
  参考文献：
  名称：

  Total Synthesis of Caerulomycin C via the Halogen Dance Reaction

  摘要：

  [GRAPHICS]The total synthesis of caerulomycin C is described. Key steps in this synthesis utilize 1,2-, 1,3-, and 1,4-halogen dance reactions for the functionalization of the pyridine ring.

  DOI：

  10.1021/ol026135m
• 作为产物：
  描述：

  二异丙胺 以 甲醇 、 二氯甲烷 为溶剂， 反应 18.5h， 生成 N,N-二异丙基-4-甲氧基吡啶甲酰胺
  参考文献：
  名称：

  Total Synthesis of Caerulomycin C via the Halogen Dance Reaction

  摘要：

  [GRAPHICS]The total synthesis of caerulomycin C is described. Key steps in this synthesis utilize 1,2-, 1,3-, and 1,4-halogen dance reactions for the functionalization of the pyridine ring.

  DOI：

  10.1021/ol026135m

文献信息

• A novel one-pot synthesis of 7-methoxy-2-arylthieno[3,2-b]pyridine-3-ols in domino fashion
  作者：Srinu Puvvala、Vinod D. Jadhav、Sheikh M. Farooq、Balaram Patro、Ch. Venkata Ramana Reddy

  DOI：10.1016/j.tetlet.2013.07.024

  日期：2013.9

  A simple and efficient synthesis of 7-methoxy-2-arylthieno[3,2-b]pyridine-3-ols was achieved using a novel one-pot LDA-promoted domino reaction. Although this class of compounds are not very well represented in the literature, similar skeletons are of immense biological importance. A few closely related compounds are reported with multi-step syntheses using harsh conditions and longer reaction time. (C) 2013 Elsevier Ltd. All rights reserved.
• [EN] A PROCESS FOR THE SYNTHESIS OF 4-ALKOXY-3-HYDROXYPICOLINIC ACIDS AND INTERMEDIATES THEREOF<br/>[FR] PROCÉDÉ DE SYNTHÈSE D'ACIDES 4-ALCOXY-3-HYDROXYPICOLINIQUES ET DE LEURS INTERMÉDIAIRES
  申请人：[en]PI INDUSTRIES LTD.

  公开号：WO2024018354A1

  公开（公告）日：2024-01-25

  The present invention discloses a process for the synthesis of 4- alkoxy-3-hydroxypicolinic acids of formula (I) from 2-picolinic acid. The present invention further discloses a process for preparation of compounds of formula (iii) from compounds of formula (ii). The present invention also discloses novel intermediate compounds of formula (iii).
• Total Synthesis of Caerulomycin C via the Halogen Dance Reaction
  作者：Tarek Sammakia、Eric L. Stangeland、Mark C. Whitcomb

  DOI：10.1021/ol026135m

  日期：2002.7.1

  [GRAPHICS]The total synthesis of caerulomycin C is described. Key steps in this synthesis utilize 1,2-, 1,3-, and 1,4-halogen dance reactions for the functionalization of the pyridine ring.