benzo[b]thiophene-4-sulfonamide | 848361-97-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻吩类
• 英文名称: benzo[b]thiophene-4-sulfonamide
• 英文别名: 1-Benzothiophene-4-sulfonamide
• CAS: 848361-97-7
• 化学式: C₈H₇NO₂S₂
• 分子量: 213.281
• InChiKey: NCLZEOMUURXANT-UHFFFAOYSA-N

物化性质

• 沸点：
  432.6±37.0 °C(Predicted)
• 密度：
  1.502±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  96.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2,4-二氯苯甲酸 、 benzo[b]thiophene-4-sulfonamide 在 4-二甲氨基吡啶 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 生成 N-(1-benzothiophen-4-ylsulfonyl)-2,4-dichlorobenzamide
  参考文献：
  名称：

  Acyl sulfonamide anti-proliferatives. Part 2: Activity of heterocyclic sulfonamide derivatives

  摘要：

  The anti-proliferative activity of acylated heterocyclic sulfonamides is described in Vascular Endothelial Growth Factor-dependent Human Umbilical Vascular Endothelial Cells (VEGF-HUVEC) and in HCT116 tumor cells in a soft agar diffusion assay. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.11.041
• 作为产物：
  描述：

  4-溴苯并[B]噻吩 在 ammonium hydroxide 、 叔丁基锂 作用下， 以 乙醚 、 丙酮 、 正戊烷 为溶剂， 反应 3.25h， 生成 benzo[b]thiophene-4-sulfonamide
  参考文献：
  名称：

  Acyl sulfonamide anti-proliferatives. Part 2: Activity of heterocyclic sulfonamide derivatives

  摘要：

  The anti-proliferative activity of acylated heterocyclic sulfonamides is described in Vascular Endothelial Growth Factor-dependent Human Umbilical Vascular Endothelial Cells (VEGF-HUVEC) and in HCT116 tumor cells in a soft agar diffusion assay. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.11.041

文献信息

• Modulators of the Cystic Fibrosis Transmembrane Conductance Regulator Protein and Methods of Use
  申请人：AbbVie S.à.r.l.

  公开号：US20180244611A1

  公开（公告）日：2018-08-30

  The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treating cystic fibrosis by administering a compound of the invention.
• US6376523B1
  申请人：——

  公开号：US6376523B1

  公开（公告）日：2002-04-23
• [EN] MODULATORS OF THE CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR PROTEIN AND METHODS OF USE<br/>[FR] MODULATEURS DE PROTÉINE RÉGULATRICE DE CONDUCTANCE TRANSMEMBRANAIRE DE LA FIBROSE KYSTIQUE ET PROCÉDÉS D'UTILISATION
  申请人：ABBVIE SARL

  公开号：WO2018154519A1

  公开（公告）日：2018-08-30

  The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treating cystic fibrosis by administering a compound of the invention. In one embodiment, the compound is a compound of Formula (I), or a pharmaceutically acceptable salt thereof, (I) wherein A1 is selected from the group consisting of X1, X2, X3, X4; R1, R2A, R2B, R2C, R2D, R3, R4,R5A, R5B, R5C, R5D, R6A, R6B, R6C, R6D, R7, R8, R9, R10, R11, R12, R13, and R14 are as described herein.
• Acyl sulfonamide anti-proliferatives. Part 2: Activity of heterocyclic sulfonamide derivatives
  作者：Mary M. Mader、Chuan Shih、Eileen Considine、Alfonso De Dios、Cora Sue Grossman、Philip A. Hipskind、Ho-Shen Lin、Karen L. Lobb、Beatriz Lopez、José E. Lopez、Luisa M. Martin Cabrejas、Michael E. Richett、Wesley T. White、Yiu-Yin Cheung、Zhongping Huang、John E. Reilly、Sean R. Dinn

  DOI：10.1016/j.bmcl.2004.11.041

  日期：2005.2

  The anti-proliferative activity of acylated heterocyclic sulfonamides is described in Vascular Endothelial Growth Factor-dependent Human Umbilical Vascular Endothelial Cells (VEGF-HUVEC) and in HCT116 tumor cells in a soft agar diffusion assay. (C) 2004 Elsevier Ltd. All rights reserved.