(+/-) cis 2-methylamino-1-indanol | 857773-72-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: (+/-) cis 2-methylamino-1-indanol
• 英文别名: (1R*,2R*)-2-methylamino-1-indanol；cis 2-methylamino-1-indanol；2-(methylamino)-2,3-dihydro-1H-inden-1-ol
• CAS: 857773-72-9
• 化学式: C₁₀H₁₃NO
• 分子量: 163.219
• InChiKey: MVXMWBCEMDLFPP-UHFFFAOYSA-N

物化性质

• 熔点：
  77-79 °C
• 沸点：
  293.3±7.0 °C(Predicted)
• 密度：
  1.14±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  (1S,2S)-2-N-methoxycarbonylamino-1-indanol 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 生成 (+/-) cis 2-methylamino-1-indanol
  参考文献：
  名称：

  Chiral .alpha.-amino ketones from the Friedel-Crafts reaction of protected amino acids

  摘要：

  DOI：

  10.1021/jo00324a057

文献信息

• [EN] CARBOCYCLIC HYDRAZINO INHIBITORS OF COPPER-CONTAINING AMINE OXIDASES<br/>[FR] INHIBITEURS HYDRAZINO CARBOCYCLIQUES DES AMINE OXYDASES A TENEUR EN CUIVRE
  申请人：BIOTIE THERAPIES CORP

  公开号：WO2003006003A1

  公开（公告）日：2003-01-23

  The present invention is directed to carbocyclic hydrazino compounds that function as inhibitors of copper-containing amine oxidases commonly known as semicarbazide-sensitive amine oxidases (SSAO), including the human SSAO known as Vascular Adhesion Protein-1 (VAP-1). These SSAO inhibitors have therapeutic utility as drugs to treat conditions and diseases including, but not limited to, a number of inflammatory conditions and diseases (in particular chronic inflammatory conditions such as chronic arthritis, inflammatory bowel diseases, and chronic skin dermatoses), diseases related to carbohydrate metabolism and to aberrations in adipocyte differentiation or function and smooth muscle cell function, and vascular diseases. The novel compounds have the general formula: or a pharmaceutically acceptable solvate, hydrate, or salt thereof, wherein R?1 to R11¿ are as defined herein.

  本发明涉及碳环肼类化合物，作为含铜胺氧化酶（常称为半卡巴肼敏感的胺氧化酶（SSAO））的抑制剂，包括人类SSAO，即血管粘附蛋白-1（VAP-1）。这些SSAO抑制剂具有治疗作用，可用作药物治疗包括但不限于多种炎症状况和疾病（尤其是慢性炎症状况，如慢性关节炎、炎症性肠病和慢性皮肤病）、与碳水化合物代谢和脂肪细胞分化或功能异常以及平滑肌细胞功能相关的疾病以及血管疾病。新型化合物的一般式为：或其药学上可接受的溶剂、水合物或盐，其中R？1到R11？如本文所定义。
• Carbocyclic hydrazino inhibitors of copper-containing amine oxidases
  申请人：——

  公开号：US20040236108A1

  公开（公告）日：2004-11-25

  The present invention is directed to carbocyclic hydrazino compounds that function as inhibitors of copper-containing amine oxidases commonly known as semicarbazide-sensitive amine oxidases (SSAO), including the human SSAO known as Vascular Adhesion Protein-1 (VAP-1). These SSAO inhibitors have therapeutic utility as drugs to treat conditions and diseases including, but not limited to, a number of inflammatory conditions and diseases (in particular chronic inflammatory conditions such as chronic arthritis, inflammatory bowel diseases, and chronic skin dermatoses), diseases related to carbohydrate metabolism and to aberrations in adipocyte differentiation or function and smooth muscle cell function, and vascular diseases. The novel compounds have the general formula: 1 or a pharmaceutically acceptable solvate, hydrate, or salt thereof, wherein R 1 to R 11 are as defined herein.

  本发明涉及碳环酰肼化合物，其作为含铜胺氧化酶抑制剂，通常被称为半卡巴肼敏感胺氧化酶（SSAO）的抑制剂，包括人类SSAO，即血管黏附蛋白-1（VAP-1）。这些SSAO抑制剂具有治疗效用，可用作治疗条件和疾病的药物，包括但不限于多种炎症条件和疾病（特别是慢性炎症条件，如慢性关节炎，炎症性肠病和慢性皮肤皮疹），与碳水化合物代谢和脂肪细胞分化或功能异常以及平滑肌细胞功能和血管疾病有关的疾病。新型化合物的一般公式为：1或其药学上可接受的溶剂化合物、水合物或盐，其中R1到R11的定义如本文所述。
• The (R,R)-enantiomer of trans-indeno(1,2-b)-1,4-oxazines, process for its preparation and pharmaceutical formulation containing it
  申请人：Merck & Co., Inc.

  公开号：EP0080117B1

  公开（公告）日：1987-12-02
• INDANE AND TETRAHYDRONAPHTHALENE DERIVATIVES AS CALCIUM CHANNEL ANTAGONISTS
  申请人：SMITHKLINE BEECHAM PLC

  公开号：EP0711272A1

  公开（公告）日：1996-05-15
• EP1414426A1
  申请人：——

  公开号：EP1414426A1

  公开（公告）日：2004-05-06