异-罗汉果皂苷V | 1126032-65-2

• 物质功能分类: 生物化工 - 提取物 - 植物提取物
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 中文名称: 异-罗汉果皂苷V
• 中文别名: 异罗汉果皂苷V；异罗汉果皂苷 V
• 英文名称: isomogroside V
• 英文别名: 3-[(4-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]-mogrol-24-O-β-D-glucopyranosyl-(1-2)-O-[β-D-glucopyranosyl-(1-6)]-β-D-glucopyranoside；Isomogroside V；(2R,3R,4S,5S,6R)-2-[[(2R,3S,4S,5R,6S)-6-[(3R,6R)-6-[(3S,8S,9R,10R,11R,13R,14S,17R)-3-[(2R,3R,4R,5S,6R)-3,4-dihydroxy-6-(hydroxymethyl)-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-11-hydroxy-4,4,9,13,14-pentamethyl-2,3,7,8,10,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-hydroxy-2-methylheptan-3-yl]oxy-3,4-dihydroxy-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]methoxy]-6-(hydroxymethyl)oxane-3,4,5-triol
• CAS: 1126032-65-2
• 化学式: C₆₀H₁₀₂O₂₉
• 分子量: 1287.45
• InChiKey: SQKPHECGTGXVQW-MRLZYGMXSA-N

物化性质

• 密度：
  1.51±0.1 g/cm3 (20 ºC 760 Torr)
• 溶解度：
  溶于DMSO和甲烷

计算性质

• 辛醇/水分配系数(LogP)：
  -3.7
• 重原子数：
  89
• 可旋转键数：
  20
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.97
• 拓扑面积：
  477
• 氢给体数：
  19
• 氢受体数：
  29

安全信息

• WGK Germany：
  3

反应信息

• 作为反应物：
  描述：

  异-罗汉果皂苷V 在 盐酸 、 水 作用下， 反应 1.5h， 生成 葡萄糖
  参考文献：
  名称：

  Cucurbitane Glycosides from Siraitia grosvenorii

  摘要：

  Systematic phytochemical studies of the extract of Luo Han Go (Siraitia grosvenorii) furnished six known cucurbitane glycosides, namely, mogrosides IVa, mogrosides V and VI, isomogroside V, 11-oxomogroside V, and siamenoside I. The structures of all the isolated compounds were characterized on the basis of extensive spectral and chemical studies. Though the partial NMR spectral data has been reported for some of the isolated compounds previously, the complete H-1 and C-13 NMR spectral assignments of all the isolated compounds are reported herewith for the first time based on COSY, HSQC, HMBC, and NOESY spectroscopic data.

  DOI：

  10.1080/07328303.2011.583511

文献信息

• Chemosensory Receptor Ligand-Based Therapies
  申请人：Baron Alain D.

  公开号：US20130281387A1

  公开（公告）日：2013-10-24

  Provided herein are methods for treating conditions associated with a chemosensory receptor, including diabetes, obesity, and other metabolic diseases, disorders or conditions by administering a composition comprising a chemosensory receptor ligand. Also provided herein are chemosensory receptor ligand compositions and methods for the preparation thereof for use in the methods of the present invention.
• [EN] CHEMOSENSORY RECEPTOR LIGAND-BASED THERAPIES<br/>[FR] THÉRAPIES BASÉES SUR UN LIGAND DE RÉCEPTEUR CHIMIOSENSORIEL
  申请人：ELCELYX THERAPEUTICS INC

  公开号：WO2012054528A2

  公开（公告）日：2012-04-26

  Provided herein are methods for treating conditions associated with a chemosensory receptor, including diabetes, obesity, and other metabolic diseases, disorders or conditions by administering a composition comprising a chemosensory receptor ligand. Also provided herein are chemosensory receptor ligand compositions and methods for the preparation thereof for use in the methods of the present invention.