5,5-Dimethyl-3-oxo-1-p-tolylhydrazino-1-cyclohexen | 70092-84-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5,5-Dimethyl-3-oxo-1-p-tolylhydrazino-1-cyclohexen
• 英文别名: 5,5-Dimethyl-3-[2-(4-methylphenyl)hydrazinyl]cyclohex-2-en-1-one
• CAS: 70092-84-1
• 化学式: C₁₅H₂₀N₂O
• 分子量: 244.337
• InChiKey: KWYXUCPHZGJELC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  41.1
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5,5-Dimethyl-3-oxo-1-p-tolylhydrazino-1-cyclohexen 在 sodium periodate 作用下， 以 甲醇 、 溶剂黄146 为溶剂， 生成 5,5-Dimethyl-3-oxo-1-p-tolylazo-1-cyclohexen
  参考文献：
  名称：

  El Ashry,E.S.H. et al., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1978, vol. 16B, p. 871 - 875

  摘要：

  DOI：
• 作为产物：
  描述：

  4-甲基苯肼盐酸盐 、 5,5-二甲基-1,3-环己二酮 以 水 为溶剂， 生成 5,5-Dimethyl-3-oxo-1-p-tolylhydrazino-1-cyclohexen
  参考文献：
  名称：

  New N-arylamino biquinoline derivatives: Synthesis, antimicrobial, antituberculosis, and antimalarial evaluation

  摘要：

  A new series of N-arylamino biquinoline derivatives 5a-x were synthesized by reaction of 2-chloro-3-formyl quinolines 2a-d with malononitrile and various enhydrazinoketones 4a-f in absolute ethanol. The newly synthesized compounds were evaluated for their in vitro antimicrobial activity against a representative panel of pathogenic strains and antituberculosis activity against Mycobacterium tuberculosis H37Rv. Compounds Sh and Ss exhibited excellent antibacterial activity and some of the compounds demonstrated moderate antituberculosis activities compared with the first line drugs. The compounds were evaluated in vitro for their activity against the growth of Plasmodium falciparum, the malaria causing parasite. Some of them showed antimalarial activity with IC50 values as low as 0.005-0.009 mu g/mL. (C) 2012 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2012.05.004

文献信息

• New N-arylamino biquinoline derivatives: microwave-assisted synthesis and their antimicrobial activities
  作者：Nimesh M. Shah、Manish P. Patel、Ranjan G. Patel

  DOI：10.1007/s00044-012-0031-0

  日期：2013.1

  A new series of N-arylamino biquinoline derivatives 5a–x were synthesized under microwave irradiation technique in good yields compared with conventional method and screened for their antimicrobial activity. All the synthesized compounds have been established by elemental analysis, IR, 1H NMR, 13C NMR and mass spectral data. In vitro antimicrobial activity was carried out against three Gram-positive

  与常规方法相比，在微波辐射技术下以高收率合成了一系列新的N-芳基氨基联喹啉衍生物5a – x，并对其抗菌活性进行了筛选。通过元素分析，IR，1 H NMR，13 C NMR和质谱数据确定了所有合成的化合物。对三种革兰氏阳性菌（枯草芽孢杆菌，破伤风梭菌，肺炎链球菌），三种革兰氏阴性菌（大肠杆菌，鼠伤寒沙门氏菌，霍乱弧菌）进行了体外抗菌活性）和两种真菌（烟曲霉，白色念珠菌）采用肉汤微量稀释法。在研究的化合物中，化合物5u对肺炎链球菌和伤寒沙门氏菌显示出有希望的抗菌活性。
• ——
  作者：B. V. Lichitsky、D. V. Kozhinov、V. N. Nesterov、L. G. Vorontsova、Z. A. Starikova、A. A. Dudinov、M. M. Krayushkin

  DOI：10.1023/a:1021300518167

  日期：——

  A general and convenient method for the synthesis of 11-aryl-1-oxo-2,3,4,5,10b,11-hexahydro-1H-indolo[2,3-b]quinoline-10b-carbonitriles was elaborated. The method is based on the novel stereoselective rearrangement of fused N-arylamino-substituted 1,4-dihydropyridines. The structures of the synthesized compounds were studied using H-1 NMR spectroscopy and X-ray diffraction analysis.
• EL ASHRY E. S. H.; LABIB G. H.; SHABAN M. A. E.; EL SAYED F., INDIAN J. CHEM., 1978, B 16, NO 10, 871-875
  作者：EL ASHRY E. S. H.、 LABIB G. H.、 SHABAN M. A. E.、 EL SAYED F.

  DOI：——

  日期：——
• New N-arylamino biquinoline derivatives: Synthesis, antimicrobial, antituberculosis, and antimalarial evaluation
  作者：Nimesh M. Shah、Manish P. Patel、Ranjan G. Patel

  DOI：10.1016/j.ejmech.2012.05.004

  日期：2012.8

  A new series of N-arylamino biquinoline derivatives 5a-x were synthesized by reaction of 2-chloro-3-formyl quinolines 2a-d with malononitrile and various enhydrazinoketones 4a-f in absolute ethanol. The newly synthesized compounds were evaluated for their in vitro antimicrobial activity against a representative panel of pathogenic strains and antituberculosis activity against Mycobacterium tuberculosis H37Rv. Compounds Sh and Ss exhibited excellent antibacterial activity and some of the compounds demonstrated moderate antituberculosis activities compared with the first line drugs. The compounds were evaluated in vitro for their activity against the growth of Plasmodium falciparum, the malaria causing parasite. Some of them showed antimalarial activity with IC50 values as low as 0.005-0.009 mu g/mL. (C) 2012 Elsevier Masson SAS. All rights reserved.
• El Ashry,E.S.H. et al., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1978, vol. 16B, p. 871 - 875
  作者：El Ashry,E.S.H. et al.

  DOI：——

  日期：——