22-[[(1S)-5-amino-1-carboxypentyl]amino]-22-oxodocosa-10,12-diynoic acid | 736142-36-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 22-[[(1S)-5-amino-1-carboxypentyl]amino]-22-oxodocosa-10,12-diynoic acid
• CAS: 736142-36-2
• 化学式: C₂₈H₄₆N₂O₅
• 分子量: 490.684
• InChiKey: AODGCSFFTFZESX-VWLOTQADSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  35
• 可旋转键数：
  23
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  130
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  三氟乙酰赖氨酸 在 氢氧化钾 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 36.0h， 生成 22-[[(1S)-5-amino-1-carboxypentyl]amino]-22-oxodocosa-10,12-diynoic acid
  参考文献：
  名称：

  Functional Self-Assembling Bolaamphiphilic Polydiacetylenes as Colorimetric Sensor Scaffolds

  摘要：

  Conjugated polymers capable of responding to external stimuli by changes in optical, electrical, or electrochemical properties can be used for the construction of direct sensing devices. Polydiacetylene-based systems are attractive for sensing applications due to their colorimetric response to changes in the local environment. Here we present the design, preparation, and characterization of self-assembling functional bolaamphiphilic polydiacetylenes (BPDAs) inspired by nature's strategy for membrane stabilization. We show that by placing polar headgroups on both ends of the diacetylene lipids in a transmembranic fashion and by altering the chemical nature of the polar surface residues, the conjugated polymers can be engineered to display a range of radiation-, thermal-, and pH-induced colorimetric responses. We observed dramatic nanoscopic morphological transformations accompanying charge-induced chromatic transitions, suggesting that both side-chain disordering and main-chain rearrangement play important roles in altering the effective conjugation lengths of the poly(ene-yne). These results establish the foundation for further development of BPDA-based colorimetric sensors.

  DOI：

  10.1021/ja039825+