2-溴甲基-3-羟基吡啶 氢溴化物 | 87440-88-8

• 物质功能分类: 医药中间体 - 杂环化合物 - 吡啶类化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 2-溴甲基-3-羟基吡啶 氢溴化物
• 中文别名: 2-溴甲基-3-羟基吡啶溴酸盐；2-溴甲基-3-羟基吡啶氢溴化物
• 英文名称: 2-bromomethyl-3-hydroxypyridine hydrobromide
• 英文别名: 2-bromomethyl-pyridin-3-ol; hydrobromide；2-Brommethyl-pyridin-3-ol; Hydrobromid；2-(bromomethyl)-3-pyridinol hydrobromide；2-(Bromomethyl)pyridin-1-ium-3-ol;bromide
• CAS: 87440-88-8
• 化学式: BrH*C₆H₆BrNO
• 分子量: 268.936
• InChiKey: YEZLFBCEZYSGQC-UHFFFAOYSA-N

物化性质

• 熔点：
  191-193°C
• 稳定性/保质期：
  按规定使用和贮存的物质不会分解，应避免接触氧化物和酸。

计算性质

• 辛醇/水分配系数(LogP)：
  2.26
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  33.1
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 危险等级：
  8
• 危险品标志：
  Xn
• 安全说明：
  S26,S36/37/39,S39
• 危险类别码：
  R34,R41,R37/38,R22
• 海关编码：
  2933399090
• 包装等级：
  II
• 危险品运输编号：
  UN 3263

反应信息

• 作为反应物：
  描述：

  2-溴甲基-3-羟基吡啶 氢溴化物 在 甲醇 、 palladium on activated charcoal 作用下， 生成 3-羟基-2-甲基吡啶
  参考文献：
  名称：

  1,1,4,4-Tetraanisyl-1,3-butadiene

  摘要：

  DOI：

  10.1021/ja01177a006
• 作为产物：
  描述：

  (3-乙酰氧基吡啶-2-基)乙酸甲酯 在 水 、 氢溴酸 作用下， 生成 2-溴甲基-3-羟基吡啶 氢溴化物
  参考文献：
  名称：

  1,1,4,4-Tetraanisyl-1,3-butadiene

  摘要：

  DOI：

  10.1021/ja01177a006

文献信息

• TETRAHYDROCYCLOPENTA[b] INDOLE COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS
  申请人：Gavardinas Konstantinos

  公开号：US20100069404A1

  公开（公告）日：2010-03-18

  The present invention provides a compound of the formula: Formula (I) or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising a compound of Formula (I) in combination with a suitable carrier, diluent, or excipient; and methods for treating physiological disorders, particularly reduced bones mass, osteoporosis, osteopenia, or reduced muscle mass or strength, comprising administering a compound of Formula (I), or a pharmaceutically acceptable salt thereof. X-17142.

  当前发明提供了一种公式为：公式(I)或其药用可接受盐的化合物；包含公式(I)的化合物与适宜的载体、稀释剂或助剂的药物组合物；以及用于治疗生理紊乱的方法，特别是减少骨量、骨质疏松症、骨量减少或减少肌肉质量或力量，包括给予公式(I)的化合物，或其药用可接受盐。X-17142。
• 3 -AMINO- PYRAZOLE DERIVATIVES USEFUL AGAINST TUBERCULOSIS
  申请人：Castro Pichel Julia

  公开号：US20130203802A1

  公开（公告）日：2013-08-08

  A compound of Formula (I) or a pharmaceutically acceptable salt thereof: Wherein: Het is a 5 to 10-membered heteroaromatic ring; Either X is N and Y is CR 5 ; or X is C and Y is S; Z is selected from N and CH; R 1 is selected from H and C 1-2 alkyl; R 2 is selected from H, C 1-2 alkyl, OH, —CH 2 OH and C 1-2 alkoxy; Each R 3 is independently selected from OH, C 1-3 alkyl, F, Cl, Br, NH 2 , and C 1-3 alkoxy; R 4 is selected from C 1-3 alkyl and haloC 1-3 alkyl; R 5 is selected from H, C 1-3 alkyl and haloC 1-3 alkyl; R 6 and R 7 are either i) each independently selected from H, C 1-3 alkyl and C 1-3 alkoxy; or ii) R 6 and R 7 together with the ring to which they are attached form a 9-membered bicyclic ring; p is 0-3; and R A is selected from H and C 1-3 alkyl, compositions containing them, their use in therapy, for example in the treatment of tuberculosis, and methods for the preparation of such compounds, are provided.

  公式（I）的化合物或其药用盐：其中：Het是5至10成员的杂环芳香环；X为N且Y为CR5；或X为C且Y为S；Z从N和CH中选择；R1从H和C1-2烷基中选择；R2从H、C1-2烷基、OH、—CH2OH和C1-2烷氧基中选择；每个R3独立选择自OH、C1-3烷基、F、Cl、Br、NH2和C1-3烷氧基；R4从C1-3烷基和卤代C1-3烷基中选择；R5从H、C1-3烷基和卤代C1-3烷基中选择；R6和R7要么i）各自独立选择自H、C1-3烷基和C1-3烷氧基；要么ii）R6和R7与它们附着的环一起形成9成员双环环；p为0-3；RA从H和C1-3烷基中选择，提供了含有它们的组合物，它们在治疗中的使用，例如在结核病的治疗中，并提供了这类化合物的制备方法。
• 2-AMINOPYRIDINE ANALOGS AS GLUCOKINASE ACTIVATORS
  申请人：Aicher Thomas D.

  公开号：US20090156603A1

  公开（公告）日：2009-06-18

  Provided are compounds of formula I that are useful in the treatment and/or prevention of diseases mediated by deficient levels of glucokinase activity, such as diabetes meilitus. Also provided are methods of treating or preventing diseases and disorders characterized by underactivity of glucokinase or which can be treated by activating glucokinase.

  提供了化学式I的化合物，这些化合物在治疗和/或预防由胰岛素活性不足引起的疾病中非常有用，例如糖尿病。还提供了治疗或预防由胰岛素活性不足或可以通过激活胰岛素来治疗的疾病和疾患的方法。
• [EN] 3 -AMINO- PYRAZOLE DERIVATIVES USEFUL AGAINST TUBERCULOSIS<br/>[FR] DÉRIVÉS DE 3-AMINO-PYRAZOLE UTILES CONTRE LA TUBERCULOSE
  申请人：GLAXO GROUP LTD

  公开号：WO2012049161A1

  公开（公告）日：2012-04-19

  A compound of Formula (I) or a pharmaceutically acceptable salt thereof: (I), Wherein: Het is a 5 to 10-membered heteroaromatic ring; Either X is N and Y is CR5; or X is C and Y is S; Z is selected from N and CH; R1 is selected from H and C1-2alkyl; R2 is selected from H, C1-2alkyl, OH, -CH2OH and C1-2alkoxy; Each R3 is independently selected from OH, C1-3alkyl, F, Cl, Br, NH2, and C1-3alkoxy; R4 is selected from C1-3alkyl and haloC1-3alkyl; R5 is selected from H, C1-3alkyl and haloC1-3alkyl; R6 and R7 are either i) each independently selected from H, C1-3alkyl and C1-3alkoxy; or ii) R6 and R7 together with the ring to which they are attached form a 9-membered bicylic ring; p is 0-3; and RA is selected from H and C1-3alkyl, compositions containing them, their use in therapy, for example in the treatment of tuberculosis, and methods for the preparation of such compounds, are provided.

  化合物的化学式（I）或其药学上可接受的盐：（I），其中：Het是一个5到10个成员的杂芳环；X是N且Y是CR5；或X是C且Y是S；Z从N和CH中选择；R1从H和C1-2烷基中选择；R2从H，C1-2烷基，OH，-CH2OH和C1-2烷氧基中选择；每个R3独立地从OH，C1-3烷基，F，Cl，Br，NH2和C1-3烷氧基中选择；R4从C1-3烷基和卤代C1-3烷基中选择；R5从H，C1-3烷基和卤代C1-3烷基中选择；R6和R7要么i）各自独立地从H，C1-3烷基和C1-3烷氧基中选择；要么ii）R6和R7与它们附着的环一起形成一个9个成员的双环环；p为0-3；RA从H和C1-3烷基中选择，提供了含有它们的组合物，它们在治疗中的用途，例如在结核病治疗中的用途，以及这类化合物的制备方法。
• 3-amino-pyrazole derivatives useful against tuberculosis
  申请人：Castro Pichel Julia

  公开号：US08779153B2

  公开（公告）日：2014-07-15

  A compound of Formula (I) or a pharmaceutically acceptable salt thereof: Wherein: Het is a 5 to 10-membered heteroaromatic ring; Either X is N and Y is CR5; or X is C and Y is S; Z is selected from N and CH; R1 is selected from H and C1-2alkyl; R2 is selected from H, C1-2alkyl, OH, —CH2OH and C1-2alkoxy; Each R3 is independently selected from OH, C1-3alkyl, F, Cl, Br, NH2, and C1-3alkoxy; R4 is selected from C1-3alkyl and haloC1-3alkyl; R5 is selected from H, C1-3alkyl and haloC1-3alkyl; R6 and R7 are either i) each independently selected from H, C1-3alkyl and C1-3alkoxy; or ii) R6 and R7 together with the ring to which they are attached form a 9-membered bicylic ring; p is 0-3; and RA is selected from H and C1-3alkyl, compositions containing them, their use in therapy, for example in the treatment of tuberculosis, and methods for the preparation of such compounds, are provided.

  化合物的式子（I）或其药学上可接受的盐： 其中：Het是5至10个成员的杂环芳香环；X为N且Y为CR5，或者X为C且Y为S；Z从N和CH中选择；R1从H和C1-2烷基中选择；R2从H，C1-2烷基，OH，—CH2OH和C1-2烷氧基中选择；每个R3独立地从OH，C1-3烷基，F，Cl，Br，NH2和C1-3烷氧基中选择；R4从C1-3烷基和haloC1-3烷基中选择；R5从H，C1-3烷基和haloC1-3烷基中选择；R6和R7要么各自独立地从H，C1-3烷基和C1-3烷氧基中选择；要么R6和R7与它们附着的环一起形成一个9成员的双环；p为0-3；RA从H和C1-3烷基中选择，提供了含有它们的组成物，它们在治疗中的使用，例如在结核病的治疗中，以及这种化合物的制备方法。