1,2,3,4-tri-O-acetyl-α-D-ribopyranose | 4257-95-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1,2,3,4-tri-O-acetyl-α-D-ribopyranose
• 英文别名: (3R,4R,5R)-tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate；1,2,3,4-tetraacetate-beta-D-ribopyranose；tetra-O-acetyl-α-D-ribose；Tetra-O-acetyl-α-D-ribopyranose；[(3R,4R,5R,6R)-4,5,6-triacetyloxyoxan-3-yl] acetate
• CAS: 4257-95-8
• 化学式: C₁₃H₁₈O₉
• 分子量: 318.281
• InChiKey: MJOQJPYNENPSSS-FDYHWXHSSA-N

物化性质

• 沸点：
  362.9±42.0 °C(Predicted)
• 密度：
  1.29±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  22
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  114
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  1,2,3,4-tri-O-acetyl-α-D-ribopyranose 生成 四-O-乙酰基-β-D-吡喃核糖
  参考文献：
  名称：

  The Acid-catalyzed Anomerization of Acetylated Aldopyranoses¹

  摘要：

  DOI：

  10.1021/ja01515a041
• 作为产物：
  描述：

  四-O-乙酰基-β-D-吡喃核糖 生成 1,2,3,4-tri-O-acetyl-α-D-ribopyranose
  参考文献：
  名称：

  The Acid-catalyzed Anomerization of Acetylated Aldopyranoses¹

  摘要：

  DOI：

  10.1021/ja01515a041

文献信息

• The influence of boric acid on the acetylation of aldoses: ‘one-pot’ syntheses of penta-O-acetyl-β-D-glucofuranose and its crystalline propanoyl analogue
  作者：Richard H. Furneaux、Phillip M. Rendle、Ian M. Sims

  DOI：10.1039/b002841j

  日期：——

  When glucose and boric acid are heated in acetic acid a soluble compound forms from which, with acetic anhydride and catalytic amounts of sulfuric acid, a mixture consisting of >90% of the glucofuranose per-acetates (α∶β ratio 1∶1.8) is obtained in high yield. In the absence of the sulfuric acid partial acetylation takes place and penta-O-acetyl-β-D-glucofuranose (α∶β ratio 1∶52) is obtainable in good yield by removal of boric acid and completion of the esterification by addition of acetic anhydride and pyridine. A new, crystalline glucofuranose, penta-O-propanoyl-β-D-glucofuranose, is obtained in 58% yield in a ‘one-pot’ procedure using boric acid. The effects of boric acid on the acid-catalysed acetylation of other aldo-hexoses and -pentoses suggest that the synthesis of furanosyl per-esters could be successful with xylose and idose as well as with glucose. p

  当葡萄糖和硼酸在醋酸中加热时，会形成一种可溶性化合物，从中通过醋酐和少量的硫酸催化，可以获得含有>90%的葡萄呋喃糖全乙酸酯（α∶β比率为1∶1.8）的高产率混合物。在没有硫酸的情况下，会发生部分乙酰化，通过去除硼酸并加入醋酐和吡啶完成酯化反应，可以以良好的产率获得五-O-乙酰基-β-D-葡萄呋喃糖（α∶β比率为1∶52）。通过使用硼酸的“一锅法”程序，可以以58%的产率获得一种新的结晶葡萄呋喃糖，即五-O-丙酸酰基-β-D-葡萄呋喃糖。 硼酸对其他己醛糖和戊醛糖的酸催化乙酰化反应的影响表明，与葡萄糖一样，木糖和艾杜糖的呋喃糖全酯合成也可能是成功的。
• Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier
  申请人：Mash Deborah C.

  公开号：US08637648B1

  公开（公告）日：2014-01-28

  This invention relates generally to compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier.

  这项发明通常涉及包含诺利波甲碱和辅助剂以促进穿越血脑屏障的组合物。
• Benzophenone alpha-d-glycopyranosides, preparation and therapeutic use
  申请人：——

  公开号：US20030139349A1

  公开（公告）日：2003-07-24

  The invention concerns (i) [4-(4-cyanobenzyl)phenyl]&agr;-D-glycopyranosides of formula (I) wherein: the group &agr;-D-glycopyranosyl R represents a &agr;-D-glycopyranosyl, &agr;-D-galactopyranosyl. &agr;-D-mannopyranosyl, &agr;-D-arabinopyranosyl, &agr;-D-lyxopyranosyl, or &agr;-D-ribopyranosyl group: (ii) their esters resulting from the esterification of at least a OH function of each pyranosyl group with a C 2 -C 4 alkanoic or a cycloalkanoic acid, as novel industrial products. Said novel [4-(4-cyanobenzyl)phenyl]&agr;-D-glycopyranosides are useful in therapy for fighting against atheromatous plaque.

  该发明涉及公式(I)中的(4-(4-氰基苄基)苯基)α-D-葡萄糖苷，其中：α-D-葡萄糖苷R代表α-D-葡萄糖苷，α-D-半乳糖苷，α-D-阿拉伯糖苷，α-D-利索糖苷或α-D-核糖苷基团：(ii)它们是通过将每个吡喃糖基的至少一个OH功能与C2-C4烷酸或环烷酸酯化而得到的酯，作为新的工业产品。这些新型(4-(4-氰基苄基)苯基)α-D-葡萄糖苷在治疗动脉粥样硬化斑块方面具有用途。
• BENZIMIDAZOLE DERIVATIVES
  申请人：——

  公开号：US20020094963A1

  公开（公告）日：2002-07-18

  The present invention relates to certain bezimidazole derivatives and their use in medical therapy particularly for the treatment or prophylaxis of virus infections such as those caused by herpes viruses. The invention also relates to the preparation of the benzimidazole derivatives and pharmaceutical formulations containing them.

  本发明涉及某些苯并咪唑衍生物及其在医学治疗中的应用，特别是用于治疗或预防由疱疹病毒引起的病毒感染。该发明还涉及苯并咪唑衍生物的制备以及含有它们的药物配方。
• Process for preparing substituted benzimidazole compounds
  申请人：——

  公开号：US20030191127A1

  公开（公告）日：2003-10-09

  The invention relates to new methods of preparing substituted benzimidazole compounds, such as 2-bromo-5,6-dichlorobenzimidazole, which are useful in the preparation of compounds having antiviral activity.

  这项发明涉及一种制备取代苯并咪唑化合物的新方法，例如2-溴-5,6-二氯苯并咪唑，这些化合物在具有抗病毒活性的化合物的制备中非常有用。