oceanapiside

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: oceanapiside
• 英文别名: 2,27-diamino-1,26-dihydroxy-3-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoctacosan-11-one
• 化学式: C₃₄H₆₈N₂O₉
• 分子量: 648.922
• InChiKey: MTILEUGHINFLTP-WOHOVROQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  45
• 可旋转键数：
  29
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.97
• 拓扑面积：
  209
• 氢给体数：
  8
• 氢受体数：
  11

反应信息

• 作为反应物：
  描述：

  二碳酸二叔丁酯 、 oceanapiside 在 三乙胺 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 2.0h， 生成 N-t-BOC oceanapiside
  参考文献：
  名称：

  Oceanapiside, an Antifungal Bis-α,ω-amino Alcohol Glycoside from the Marine Sponge Oceanapia phillipensis

  摘要：

  The structure of oceanapiside, an antifungal alpha,omega-bis-aminohydroxylipid glycoside from the temperate marine sponge Oceanapia sp., was elucidated by a combination of 2D NMR, chemical degradation! correlation, and MALDI MS-MS spectrometry. Oceanapiside exhibits antifungal activity against Candida glabrata at 10 mu g/mL (MIC).

  DOI：

  10.1021/np990190v

文献信息

• Inhibitors of acyl glucosaminyl inositol amidase and methods of use
  申请人：——

  公开号：US20040167331A1

  公开（公告）日：2004-08-26

  The present invention provides compounds with activity as inhibitors of acyl glucosaminylinositol amidases with amidase activity against S-conjugate amides, particularly mycothiol-derived S-conjugate amides. Certain of the invention compounds are naturally occurring compounds obtained from marine sponges and other organisms. The invention further provides methods for using the compounds to inhibit virulence and reduce antibiotic resistance of mycothiol-producing bacteria.
• US7642280B2
  申请人：——

  公开号：US7642280B2

  公开（公告）日：2010-01-05
• [EN] INHIBITORS OF ACYL GLUCOSAMINYL INOSITOL AMIDASE AND METHODS OF USE<br/>[FR] INHIBITEURS D'ACYLE GLUCOSAMINYLE INOSITOL AMIDASES ET LEURS METHODES D'UTILISATION
  申请人：UNIV CALIFORNIA

  公开号：WO2002081483A2

  公开（公告）日：2002-10-17

  The present invention provides compounds with activity as inhibitors of acyl glucosaminylinositol amidases with amidase activity against S-conjugate amides, particularly mycothiol-derived S-conjugate amides. Certain of the invention compounds are naturally occurring compounds obtained from marine sponges and other organisms. The invention further provides methods for using the compounds to inhibit virulence and reduce antibiotic resistance of mycothiol-producing bacteria.