benzoic acid 2-(2,2-di-tert-butyl-[1,3,2]dioxasilinan-4-yl)-ethyl ester | 442636-12-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: benzoic acid 2-(2,2-di-tert-butyl-[1,3,2]dioxasilinan-4-yl)-ethyl ester
• 英文别名: 2-(2,2-Ditert-butyl-1,3,2-dioxasilinan-4-yl)ethyl benzoate
• CAS: 442636-12-6
• 化学式: C₂₀H₃₂O₄Si
• 分子量: 364.557
• InChiKey: RXLZDPUGPJCESZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.08
• 重原子数：
  25
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  benzoic acid 2-(2,2-di-tert-butyl-[1,3,2]dioxasilinan-4-yl)-ethyl ester 在 3 A molecular sieve 三氟二甲基硫醚络合物 、 potassium acetate 、 烯丙基三甲基硅烷 作用下， 以 氯仿 为溶剂， 以82%的产率得到benzoic acid 3-(di-tert-butyl-fluoro-silanyloxy)-5-hydroxy-pentyl ester
  参考文献：
  名称：

  The Regioselective Mono-deprotection of 1,3-Dioxa-2,2-(di-tert-butyl)-2-silacyclohexanes with BF₃·SMe₂

  摘要：

  The selective mono-deprotection of di-tert-butylsilylene ethers prepared from substituted 1,3-pentanediols and 2,4-hexanediols has been achieved with BF3.SMe2. The reaction conditions are compatible with esters, allyl ethers, and TIPS ethers. The resulting di-tert-butylfluorosilyl ethers are stable to various conditions including low pH aqueous solutions and silica gel chromatography; the di-tert-butylfluorosilyl ethers are readily cleaved with HF-pyridine. Substrate stereochemistry and conformation influences the efficiency of the deprotection, while the deprotection regiochemistry is consistent with coordination of boron to the sterically more accessible oxygen prior to intramolecular delivery of fluoride.

  DOI：

  10.1021/jo025624x
• 作为产物：
  描述：

  1,3,5-戊三醇 以 四氢呋喃 、 吡啶 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 13.67h， 生成 benzoic acid 2-(2,2-di-tert-butyl-[1,3,2]dioxasilinan-4-yl)-ethyl ester
  参考文献：
  名称：

  The Regioselective Mono-deprotection of 1,3-Dioxa-2,2-(di-tert-butyl)-2-silacyclohexanes with BF₃·SMe₂

  摘要：

  The selective mono-deprotection of di-tert-butylsilylene ethers prepared from substituted 1,3-pentanediols and 2,4-hexanediols has been achieved with BF3.SMe2. The reaction conditions are compatible with esters, allyl ethers, and TIPS ethers. The resulting di-tert-butylfluorosilyl ethers are stable to various conditions including low pH aqueous solutions and silica gel chromatography; the di-tert-butylfluorosilyl ethers are readily cleaved with HF-pyridine. Substrate stereochemistry and conformation influences the efficiency of the deprotection, while the deprotection regiochemistry is consistent with coordination of boron to the sterically more accessible oxygen prior to intramolecular delivery of fluoride.

  DOI：

  10.1021/jo025624x

文献信息

• The Regioselective Mono-deprotection of 1,3-Dioxa-2,2-(di-<i>tert</i>-butyl)-2-silacyclohexanes with BF₃·SMe₂
  作者：Ming Yu、Brian L. Pagenkopf

  DOI：10.1021/jo025624x

  日期：2002.6.1

  The selective mono-deprotection of di-tert-butylsilylene ethers prepared from substituted 1,3-pentanediols and 2,4-hexanediols has been achieved with BF3.SMe2. The reaction conditions are compatible with esters, allyl ethers, and TIPS ethers. The resulting di-tert-butylfluorosilyl ethers are stable to various conditions including low pH aqueous solutions and silica gel chromatography; the di-tert-butylfluorosilyl ethers are readily cleaved with HF-pyridine. Substrate stereochemistry and conformation influences the efficiency of the deprotection, while the deprotection regiochemistry is consistent with coordination of boron to the sterically more accessible oxygen prior to intramolecular delivery of fluoride.