4-(2-Morpholin-4-yl-ethoxy)-benzaldehyde O-(3,3-diethyl-4-oxo-azetidin-2-yl)-oxime | 266679-73-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: 4-(2-Morpholin-4-yl-ethoxy)-benzaldehyde O-(3,3-diethyl-4-oxo-azetidin-2-yl)-oxime
• 英文别名: 3,3-diethyl-4-[(E)-[4-(2-morpholin-4-ylethoxy)phenyl]methylideneamino]oxyazetidin-2-one
• CAS: 266679-73-6
• 化学式: C₂₀H₂₉N₃O₄
• 分子量: 375.468
• InChiKey: POYWQXLCWVRECF-RCCKNPSSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  27
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  72.4
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  异氰酸苄酯 、 4-(2-Morpholin-4-yl-ethoxy)-benzaldehyde O-(3,3-diethyl-4-oxo-azetidin-2-yl)-oxime 在 4-二甲氨基吡啶 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 以55%的产率得到3,3-Diethyl-2-[1-[4-(2-morpholin-4-yl-ethoxy)-phenyl]-meth-(E)-ylideneaminooxy]-4-oxo-azetidine-1-carboxylic acid benzylamide
  参考文献：
  名称：

  Synthesis, inhibitory activity towards human leukocyte elastase and molecular modelling studies of 1-carbamoyl-4-methyleneaminoxyazetidinones

  摘要：

  Some monocyclic beta-lactam derivatives of type 3 (MAOAs) in which the leaving group (LG) on the C(4) is a methyleneaminoxy moiety, were synthesised and tested in vitro and in vivo for their inhibitory activity towards human leukocyte elastase (HLE). Some compounds showed an appreciable in vitro inhibitory activity against this enzyme. Effects on the anti-HLE activity due to the nature of the substituents R and R-1 present on their LG were observed and rationalised by means of molecular modelling techniques. The results of in vivo pharmacological tests indicated that MAOAs, while showing an inhibitory activity on the haemorrhage induced by HLE, did not exhibit any effects due to the R and R-1 substituents. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

  DOI：

  10.1016/s0223-5234(00)00111-2
• 作为产物：
  描述：

  2-吗啉乙醇 在 sodium hydroxide 、 盐酸羟胺 、 potassium carbonate 、 三苯基膦 、 偶氮二甲酸二乙酯 作用下， 以 四氢呋喃 、 乙醇 、 水 、 丙酮 为溶剂， 反应 48.67h， 生成 4-(2-Morpholin-4-yl-ethoxy)-benzaldehyde O-(3,3-diethyl-4-oxo-azetidin-2-yl)-oxime
  参考文献：
  名称：

  Synthesis, inhibitory activity towards human leukocyte elastase and molecular modelling studies of 1-carbamoyl-4-methyleneaminoxyazetidinones

  摘要：

  Some monocyclic beta-lactam derivatives of type 3 (MAOAs) in which the leaving group (LG) on the C(4) is a methyleneaminoxy moiety, were synthesised and tested in vitro and in vivo for their inhibitory activity towards human leukocyte elastase (HLE). Some compounds showed an appreciable in vitro inhibitory activity against this enzyme. Effects on the anti-HLE activity due to the nature of the substituents R and R-1 present on their LG were observed and rationalised by means of molecular modelling techniques. The results of in vivo pharmacological tests indicated that MAOAs, while showing an inhibitory activity on the haemorrhage induced by HLE, did not exhibit any effects due to the R and R-1 substituents. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

  DOI：

  10.1016/s0223-5234(00)00111-2

文献信息

• Synthesis, inhibitory activity towards human leukocyte elastase and molecular modelling studies of 1-carbamoyl-4-methyleneaminoxyazetidinones
  作者：B Macchia

  DOI：10.1016/s0223-5234(00)00111-2

  日期：2000.1

  Some monocyclic beta-lactam derivatives of type 3 (MAOAs) in which the leaving group (LG) on the C(4) is a methyleneaminoxy moiety, were synthesised and tested in vitro and in vivo for their inhibitory activity towards human leukocyte elastase (HLE). Some compounds showed an appreciable in vitro inhibitory activity against this enzyme. Effects on the anti-HLE activity due to the nature of the substituents R and R-1 present on their LG were observed and rationalised by means of molecular modelling techniques. The results of in vivo pharmacological tests indicated that MAOAs, while showing an inhibitory activity on the haemorrhage induced by HLE, did not exhibit any effects due to the R and R-1 substituents. (C) 2000 Editions scientifiques et medicales Elsevier SAS.